Inhibitory effects of sunitinib on ovalbumin-induced chronic experimental asthma in mice

Chinese Medical Journal

Volumn 122, Issue 9, 2009, Pages 1061-1066

  Huang, Mao ^a   Liu, Xuan ^b   Du, Qiang ^a   Yao, Xin ^a   Yin, Kai Sheng ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Second People's Hospital of Changshu   (China)

Author keywords

Airway remodeling; Asthma; Sunitinib; Tyrosine kinase inhibitor

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; OVALBUMIN; STEM CELL FACTOR; SUNITINIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPRECIPITATION; LUNG LAVAGE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANGIOGENESIS INHIBITORS; ANIMALS; ASTHMA; BLOTTING, WESTERN; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; FEMALE; IMMUNOGLOBULIN E; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INDOLES; INFLAMMATION; INTERLEUKIN-13; INTERLEUKIN-4; LUNG; MICE; MICE, INBRED BALB C; OVALBUMIN; PROTO-ONCOGENE PROTEINS C-KIT; PYRROLES;

EID: 68149179758     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.09.010     Document Type: Article

References (29)

1. Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodelling in asthma. J Clin Invest 1999; 104: 1001-1006.
2. Hoshino M, Nakamura Y, Sim JJ, Shimojo J, Isogai S. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J Allergy Clin Immunol 1998; 102: 783-788.
3. Kim SJ, Kim CH, Ahn JH, Kim MS, Kim SC, Lee SY, et al. Time sequence of airway remodelling in a mouse model of chronic asthma: the relation with airway hyperresponsiveness. J Korean Med Sci 2007; 22: 183-191.
4. Irwin RS, Richardson ND. Side effects with inhaled corticosteroids: the physician's perception. Chest 2006; 130 (1 Suppl): s41-s53.
5. Mendel DB, Douglas Laird A, Xin X, Louie SG, Christensen JG, Li G, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003; 9: 327-337.
6. Pawson T. Regulation and targets of receptor tyrosine kinases. Eur J Cancer 2002; 38 (Suppl 5): s3-s10.
7. Finke JH, Rini B, Ireland J, Rayman P, Richmond A, Golshayan A, et al. Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin Cancer Res 2008; 14: 6674-6682.
8. Lacouture ME, Reilly LM, Gerami P, Guitart J. Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib. Ann Oncol 2008; 19: 1955-1961.
9. Tugues S, Fernandez-Varo G, Muñoz-Luque J, Ros J, Arroyo V, Rodés J, et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 2007; 46: 1919-1926.
10. Locke NR, Royce SG, Wainewright JS, Samuel CS, Tang ML. Comparison of airway remodelling in acute, subacute and chronic models of allergic airways disease. Am J Respir Cell Mol Biol 2007; 36: 625-632.
11. Du Q, Chen Z, Zhou LF, Zhang Q, Huang M, Yin KS. Inhibitory effects of astrag-aloside IV on ovalbumin induced chronic experimental asthma. Can J Physiol Pharmacol 2008; 86: 449-457.
12. Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 2007; 370: 2011-2019.
13. Bian T, Yin KS, Jin SX, Zhang XL, Zhou JY, Ma XQ, et al. Treatment of allergic airway inflammation and hyperresponsiveness by imiquimod modulating transcription factors T-bet and GATA-3. Chin Med J 2006; 119: 640-648.
14. Du Q, Zhou LF, Chen Z, Gu XY, Huang M, Yin KS. Imiquimod, a toll-like receptor 7 ligand, inhibits airway remodelling in a murine model of chronic asthma. Clin Exp Pharmacol Physiol 2009; 36: 43-48.
15. Panettieri RA Jr, Murray RK, Eszterhas AJ, Bilgen G, Martin JG. Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo. Am J Physiol 1998; 274: L417-L424.
16. Fulkerson PC, Rothenberg ME, Hogan SP. Building a better mouse model: experimental models of chronic asthma. Clin Exp Allergy 2005; 35: 1251-1253.
17. Temann UA, Prasad B, Gallup MW, Basbaum C, Ho SB, Flavell RA, et al. A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion. Am J Respir Cell Mol Biol 1997; 16: 471-478.
18. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282: 2261-2263.
19. Kay AB, Phipps S, Robinson DS. A role for eosinophils in airway remodelling in asthma. Trends Immunol 2004; 25: 477-482.
20. Kariyawasam HH, Robinson DS. The role of eosinophils in airway tissue remodelling in asthma. Curr Opin Immunol 2007; 19: 681-686.
21. Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovi R, et al. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Resp Cell Mol Biol 2001; 25: 385-391.
22. Doucet C, Brouty-Boye D, Pottin-Clemenceau C, Canonica GW, Jasmin C, Azzarone B. Interleukin (IL)-4 and IL-13 act on human lung fibroblasts. Implication in asthma. J Clin Invest 1998; 101: 2129-2139.
23. Bossé Y, Thompson C, Audette K, Stankova J, Rola-Pleszczynski M. Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation. Int Arch Allergy Immunol 2008; 146: 138-48.
24. Faffe DS, Whitehead T, Moore PE, Baraldo S, Flynt L, Bourgeois K, et al. IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype. Am J Physiol Lung Cell Mol Physiol 2003; 285: L907-L914.
25. Faffe DS, Flynt L, Bourgeois K, Panettieri RA Jr, Shore SA. Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype. Am J Respir Cell Mol Biol 2006; 34: 213-218.
26. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282: 2258-2261.
27. Al-Muhsen SZ, Shablovsky G, Olivenstein R, Mazer B, Hamid Q. The expression of stem cell factor and c-kit receptor in human asthmatic airways. Clin Exp Allergy 2004; 34: 911-916.
28. Da Silva CA, Blay F, Israel-Biet D, Laval AM, Glasser N, Pauli G, et al. Effect of glucocorticoids on stem cell factor (SCF) expression in human asthmatic bronchi. Clin Exp Allergy 2006; 36: 317-324. .
29. Berlin AA, Hogaboam CM, Lukacs NW. Inhibition of SCF attenuates peribronchial remodelling in chronic cockroach allergen-induced asthma. Lab Invest 2006; 86: 557-565.