Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways augment the sensitivity to actinomycin D in Ewing sarcoma

Journal of Cancer Research and Clinical Oncology

Volumn 135, Issue 8, 2009, Pages 1125-1136

  Yamamoto, Takatoshi ^a   Ohno, Takatoshi ^a   Wakahara, Kazuhiko ^a   Nagano, Akihito ^a   Kawai, Gou ^a   Saitou, Mitsuru ^a   Takigami, Iori ^a   Matsuhashi, Aya ^a   Yamada, Kazunari ^a   Shimizu, Katsuji ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Actinomycin D; Apoptosis; Ewing sarcoma; MAP kinase; PI3 kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE; DACTINOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASSAY; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; EWING SARCOMA; FLUORESCENCE MICROSCOPE; FUSION GENE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BONE NEOPLASMS; BUTADIENES; CELL DEATH; CELL LINE, TUMOR; CHROMONES; DACTINOMYCIN; DRUG RESISTANCE, NEOPLASM; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NITRILES; ONCOGENE PROTEINS, FUSION; PHOSPHATIDYLINOSITOL 3-KINASES; RNA, SMALL INTERFERING; SARCOMA, EWING'S; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 68149156421     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-009-0554-z     Document Type: Article

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