Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma

Experimental Biology and Medicine

Volumn 234, Issue 8, 2009, Pages 918-930

  Walsh, Molly M ^a   Yi, Haiqing ^a   Friedman, Julie ^a   Cho, Kyoung In ^a   Tserentsoodol, Nomingerel ^a   McKinnon, Stuart ^a   Searle, Kelly ^a   Yeh, Andrew ^a   Ferreira, Paulo A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Biomarkers; Ganglion neurons; Gene expression; Glaucoma; Inflammation; Neurodegeneration; Pathogenesis; Retina; Stress stimuli; Vitreous

Indexed keywords

HYDROGEN PEROXIDE; SERUM AMYLOID A; SERUM AMYLOID A1; SERUM AMYLOID A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DISEASE MARKER; GANGLION; GENE EXPRESSION; GLAUCOMA; INTRAOCULAR PRESSURE; MICROGLIA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RETINA;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLAUCOMA; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; INTRAOCULAR PRESSURE; MICE; MICROGLIA; NEURONS; OCULAR HYPERTENSION; RETINA;

MUS; RODENTIA;

EID: 68149141471     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0811-RM-344     Document Type: Article

References (64)

1. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol 80:389-393, 1996.
2. Quigley HA. Neuronal death in glaucoma. Prog Retin Eye Res 18:39-57, 1999.
3. Wax MB, Tezel G. Neurobiology of glaucomatous optic neuropathy: diverse cellular events in neurodegeneration and neuroprotection. Mol Neurobiol 26:45-55, 2002.
4. Johnson EC, Jia L, Cepurna WO, Doser TA, Morrison JC. Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci 48:3161-3177, 2007.
5. Lee WR, Grierson I. Relationships between intraocular pressure and the morphology of the outflow apparatus. Trans Ophthalmol Soc U K 94:430-449, 1974.
6. Rohen JW, Witmer R. Electron microscopic studies on the trabecular meshwork in glaucoma simplex. Graefes Arch Clin Exp Ophthalmol 183:251-266, 1972.
7. Garcia-Valenzuela E, Shareef S, Walsh J, Sharma SC. Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp Eye Res 61:33-44, 1995.
8. Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, Zack DJ. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci 36:774-786, 1995.
9. Quigley HA, Addicks EM. Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport. Invest Ophthalmol Vis Sci 19:137-152, 1980.
10. Monemi S, Spaeth G, DaSilva A, Popinchalk S, Ilitchev E, Liebmann J, Ritch R, Heon E, Crick RP, Child A, Sarfarazi M. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Hum Mol Genet 14:725-733, 2005.
11. Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Heon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 295:1077-1079, 2002.
12. Stone EM, Fingert JH, Alward WL, Nguyen TD, Polansky JR, Sunden SL, Nishimura D, Clark AF, Nystuen A, Nichols BE, Mackey DA, Ritch R, Kalenak JW, Craven ER, Sheffield VC. Identification of a gene that causes primary open angle glaucoma. Science 275:668-670, 1997.
13. Wiggs JL. Genetic etiologies of glaucoma. Arch Ophthalmol 125:30-37, 2007.
14. Bejjani BA, Lewis RA, Tomey KF, Anderson KL, Dueker DK, Jabak M, Astle WF, Otterud B, Leppert M, Lupski JR. Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia. Am J Hum Genet 62:325-333, 1998.
15. Stoilov I, Akarsu AN, Sarfarazi M. Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Hum Mol Genet 6:641-647, 1997.
16. Libby RT, Gould DB, Anderson MG, John SW. Complex genetics of glaucoma susceptibility. Annu Rev Genomics Hum Genet 6:15-44, 2005.
17. Petersen MB, Kitsos G, Samples JR, Gaudette ND, Economou-Petersen E, Sykes R, Rust K, Grigoriadou M, Aperis G, Choi D, Psilas K, Craig JE, Kramer PL, Mackey DA, Wirtz MK. A large GLC1C Greek family with a myocilin T377M mutation: inheritance and phenotypic variability. Invest Ophthalmol Vis Sci 47:620-625, 2006.
18. Raymond V. Molecular genetics of the glaucomas: mapping of the first five "GLC" loci. Am J Hum Genet 60:272-277, 1997.
19. Sarfarazi M. Recent advances in molecular genetics of glaucomas. Hum Mol Genet 6:1667-1677, 1997.
20. Hewitt AW, Bennett SL, Dimasi DP, Craig JE, Mackey DA. A myocilin Gln368STOP homozygote does not exhibit a more severe glaucoma phenotype than heterozygous cases. Am J Ophthalmol 141:402-403, 2006.
21. The Advanced Glaucoma Intervention Study (AGIS): 11. Risk factors for failure of trabeculectomy and argon laser trabeculoplasty. Am J Ophthalmol 134:481-498, 2002.
22. Morrison JC, Moore CG, Deppmeier LM, Gold BG, Meshul CK, Johnson EC. A rat model of chronic pressure-induced optic nerve damage. Exp Eye Res 64:85-96, 1997.
23. Morrison JC, Johnson EC, Cepurna W, Jia L. Understanding mechanisms of pressure-induced optic nerve damage. Prog Retin Eye Res 24:217-240, 2005.
24. Miyahara T, Kikuchi T, Akimoto M, Kurokawa T, Shibuki H, Yoshimura N. Gene microarray analysis of experimental glaucomatous retina from cynomologous monkey. Invest Ophthalmol Vis Sci 44:4347-4356, 2003.
25. Ahmed F, Brown KM, Stephan DA, Morrison JC, Johnson EC, Tomarev SI. Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure. Invest Ophthalmol Vis Sci 45:1247-1258, 2004.
26. Steele MR, Inman DM, Calkins DJ, Horner PJ, Vetter ML. Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Invest Ophthalmol Vis Sci 47:977-985, 2006.
27. Yang Z, Quigley HA, Pease ME, Yang Y, Qian J, Valenta D, Zack DJ. Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms. Invest Ophthalmol Vis Sci 48:5539-5548, 2007.
28. Reitsamer HA, Kiel JW, Harrison JM, Ransom NL, McKinnon SJ. Tonopen measurement of intraocular pressure in mice. Exp Eye Res 78:799-804, 2004.
29. Aslanukov A, Bhowmick R, Guruju M, Oswald J, Raz D, Bush RA, Sieving PA, Lu X, Bock CB, Ferreira PA. RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. PLoS Genet 2:e177, 2006.
30. Cho KI, Yi H, Yeh A, Tserentsoodol N, Cuadrado L, Searle K, Hao Y, Ferreira PA. Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons. Cell Death Differ 16:287-297, 2009.
31. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:e15, 2003.
32. Ferreira PA. Characterization of RanBP2-associated molecular components in neuroretina. Methods Enzymol 315:455-468, 2000.
33. Mavlyutov TA, Cai Y, Ferreira PA. Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Traffic 3:630-640, 2002.
34. Betts JC, Edbrooke MR, Thakker RV, Woo P. The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells. Scand J Immunol 34:471-482, 1991.
35. Sellar GC, Steel DM, Zafiropoulos A, Seery LT, Whitehead AS. Characterization, expression and evolution of mouse beta 2-glycoprotein I (apolipoprotein H). Biochem Biophys Res Commun 200:1521-1528, 1994.
36. Tezel G, Wax MB. Glial modulation of retinal ganglion cell death in glaucoma. J Glaucoma 12:63-68, 2003.
37. Tezel G, Wax MB. The immune system and glaucoma. Curr Opin Ophthalmol 15:80-84, 2004.
38. Furlaneto CJ, Campa A. A novel function of serum amyloid A: a potent stimulus for the release of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8 by human blood neutrophil. Biochem Biophys Res Commun 268:405-408, 2000.
39. Yang RZ, Lee MJ, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH, Goldberg AP, Shuldiner AR, Fried SK, Gong DW. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med 3:e287, 2006.
40. Malle E, De Beer FC. Human serum amyloid A (SAA) protein: a prominent acute-phase reactant for clinical practice. Eur J Clin Invest 26:427-435, 1996.
41. Andersen JK. Oxidative stress in neurodegeneration: cause or consequence? Nat Med 10 Suppl:S18-25, 2004.
42. Izzotti A, Bagnis A, Sacca SC. The role of oxidative stress in glaucoma. Mutat Res 612:105-114, 2006.
43. Ferri KF, Kroemer G. Mitochondria - the suicide organelles. Bioessays 23:111-115, 2001.
44. Bonfanti L, Strettoi E, Chierzi S, Cenni MC, Liu XH, Martinou JC, Maffei L, Rabacchi SA. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci 16:4186-4194, 1996.
45. Deveraux QL, Reed JC. IAP family proteins - suppressors of apoptosis. Genes Dev 13:239-252, 1999.
46. Moore DF, Gelderman MP, Ferreira PA, Fuhrmann SR, Yi H, Elkahloun A, Lix LM, Brady RO, Schiffmann R, Goldin E. Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach. Proc Natl Acad Sci U S A 104:8065-8070, 2007.
47. Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 7:988-994, 2006.
48. Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev 3:401-410, 2002.
49. McKinnon SJ, Lehman DM, Tahzib NG, Ransom NL, Reitsamer HA, Liston P, LaCasse E, Li Q, Korneluk RG, Hauswirth WW. Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. Mol Ther 5:780-787, 2002.
50. Liu Q, Ju WK, Crowston JG, Xie F, Perry G, Smith MA, Lindsey JD, Weinreb RN. Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci 48:4580-4589, 2007.
51. Moreno MC, Campanelli J, Sande P, Sanez DA, Keller Sarmiento MI, Rosenstein RE. Retinal oxidative stress induced by high intraocular pressure. Free Radic Biol Med 37:803-812, 2004.
52. Mozaffarieh M, Flammer J. Is there more to glaucoma treatment than lowering IOP? Surv Ophthalmol 52 Suppl 2:S174-179, 2007.
53. Mackey AM, Sanvicens N, Groeger G, Doonan F, Wallace D, Cotter TG. Redox survival signalling in retina-derived 661W cells. Cell Death Differ 15:1291-1303, 2008.
54. Liao F, Lusis AJ, Berliner JA, Fogelman AM, Kindy M, de Beer MC, de Beer FC. Serum amyloid A protein family. Differential induction by oxidized lipids in mouse strains. Arterioscler Thromb 14:1475-1479, 1994.
55. Lindhorst E, Young D, Bagshaw W, Hyland M, Kisilevsky R. Acute inflammation, acute phase serum amyloid A and cholesterol metabolism in the mouse. Biochim Biophys Acta 1339:143-154, 1997.
56. Van Lenten BJ, Hama SY, de Beer FC, Stafforini DM, McIntyre TM, Prescott SM, La Du BN, Fogelman AM, Navab M. Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. J Clin Invest 96:2758-2767, 1995.
57. Sappington RM, Calkins DJ. Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci 49:3004-3017, 2008.
58. Zhou X, Li F, Kong L, Tomita H, Li C, Cao W. Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem 280:31240-31248, 2005.
59. Tezel G, Yang X, Luo C, Peng Y, Sun SL, Sun D. Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest Ophthalmol Vis Sci 48:705-714, 2007.
60. Wang WH, McNatt LG, Pang IH, Hellberg PE, Fingert JH, McCartney MD, Clark AF. Increased expression of serum amyloid A in glaucoma and its effect on intraocular pressure. Invest Ophthalmol Vis Sci 49:1916-1923, 2008.
61. Halfter W, Dong S, Dong A, Eller AW, Nischt R. Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body. Eye 22:1207-1213, 2008.
62. Haddad A, Laicine EM, de Almeida JC, Costa MS. Partial characterization, origin and turnover of glycoproteins of the rabbit vitreous body. Exp Eye Res 51:139-143, 1990.
63. Laurent UB, Fraser JR. Turnover of hyaluronate in the aqueous humour and vitreous body of the rabbit. Exp Eye Res 36:493-503, 1983.
64. van Deemter M, Ponsioen TL, Bank RA, Snabel JM, van der Worp RJ, Hooymans JM, Los LI. Pentosidine accumulates in the aging vitreous body: a gender effect. Exp Eye Res 88:1043-1050, 2009.