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Volumn 26, Issue 1, 2002, Pages 45-55

Neurobiology of glaucomatous optic neuropathy: Diverse cellular events in neurodegeneration and neuroprotection

Author keywords

Apoptosis; Glaucoma; Neurodegeneration; Neuroprotection; Retinal ganglion cells

Indexed keywords

ANTIGEN; HEAT SHOCK PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0036700129     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1385/mn:26:1:045     Document Type: Review
Times cited : (106)

References (102)
  • 1
    • 0027399771 scopus 로고
    • Open-angle glaucoma
    • Quigley H. A. (1993) Open-angle glaucoma. N. Eng. J. Med. 328, 1097-1106.
    • (1993) N. Eng. J. Med. , vol.328 , pp. 1097-1106
    • Quigley, H.A.1
  • 4
    • 0029980777 scopus 로고    scopus 로고
    • Number of people with glaucoma worldwide
    • Quigley H. A. (1996) Number of people with glaucoma worldwide. Br. J. Ophthalmol. 80, 389-393.
    • (1996) Br. J. Ophthalmol. , vol.80 , pp. 389-393
    • Quigley, H.A.1
  • 5
    • 0034988159 scopus 로고    scopus 로고
    • Clinical factors associated with progression of glaucomatous optic disc damage in treated patients
    • Tezel G., Siegmund K. D., Trinkaus K., Wax M. B., Kass M. A., and Kolker A. E. (2001) Clinical factors associated with progression of glaucomatous optic disc damage in treated patients. Arch. Ophthalmol. 19, 813-818.
    • (2001) Arch. Ophthalmol. , vol.19 , pp. 813-818
    • Tezel, G.1    Siegmund, K.D.2    Trinkaus, K.3    Wax, M.B.4    Kass, M.A.5    Kolker, A.E.6
  • 7
    • 0029069797 scopus 로고
    • Programmed cell death of retinal ganglion cells during experimental glaucoma
    • Garcia-Valenzuela E., Shareef S., Walsh J., and Sharma S. C. (1995) Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp. Eye. Res. 61, 33-44.
    • (1995) Exp. Eye. Res. , vol.61 , pp. 33-44
    • Garcia-Valenzuela, E.1    Shareef, S.2    Walsh, J.3    Sharma, S.C.4
  • 8
    • 0033026589 scopus 로고    scopus 로고
    • Experimental induction of retinal ganglion cell death in adult mice
    • Li Y., Schlamp C. L., and Nickells R. W. (1999) Experimental induction of retinal ganglion cell death in adult mice. Invest. Ophthalmol. Vis. Sci. 40, 1004-1008.
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 1004-1008
    • Li, Y.1    Schlamp, C.L.2    Nickells, R.W.3
  • 10
    • 0032461801 scopus 로고    scopus 로고
    • Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma
    • Wax M. B., Tezel G., and Edward P. D. (1998) Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma. Arch. Ophthalmol. 116, 993-1001.
    • (1998) Arch. Ophthalmol. , vol.116 , pp. 993-1001
    • Wax, M.B.1    Tezel, G.2    Edward, P.D.3
  • 11
    • 0021954726 scopus 로고
    • Inter-individual variation in blood supply of the optic nerve head. Its importance in various ischemic disorders of the optic nerve head, and glaucoma, low-tension glaucoma and allied disorders
    • Hayreh S. S. (1985) Inter-individual variation in blood supply of the optic nerve head. Its importance in various ischemic disorders of the optic nerve head, and glaucoma, low-tension glaucoma and allied disorders. Doce. Ophthalmol. 59, 217-246.
    • (1985) Doce. Ophthalmol. , vol.59 , pp. 217-246
    • Hayreh, S.S.1
  • 13
    • 0028433377 scopus 로고
    • The vascular concept of glaucoma
    • Flammer J. (1994) The vascular concept of glaucoma. Surv. Ophthalmol. 38 Suppl, S3-6.
    • (1994) Surv. Ophthalmol. , vol.38 , Issue.SUPPL.
    • Flammer, J.1
  • 15
    • 0016240481 scopus 로고
    • Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve
    • Anderson D. R. Jand Hendrickson A. (1974) Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve. Invest. Ophthalmol. 13, 771-783.
    • (1974) Invest. Ophthalmol. , vol.13 , pp. 771-783
    • Anderson, D.R.1    Jand Hendrickson, A.2
  • 16
    • 0017130467 scopus 로고
    • A light microscopic, autoradiographic study of axoplasmic transport in the optic nerve head during ocular hypotony, increased intraocular pressure, and papilledema
    • Minckler D. S., Tso M. O., and Zimmerman L. E. (1976) A light microscopic, autoradiographic study of axoplasmic transport in the optic nerve head during ocular hypotony, increased intraocular pressure, and papilledema. Am. J. Ophthalmol. 82, 741-757.
    • (1976) Am. J. Ophthalmol. , vol.82 , pp. 741-757
    • Minckler, D.S.1    Tso, M.O.2    Zimmerman, L.E.3
  • 17
    • 0018877393 scopus 로고
    • Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport
    • Quigley H. A. and Addicks E. M. (1980) Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport. Invest. Ophthalmol. Vis. Sci. 19, 137-152.
    • (1980) Invest. Ophthalmol. Vis. Sci. , vol.19 , pp. 137-152
    • Quigley, H.A.1    Addicks, E.M.2
  • 19
    • 0032769075 scopus 로고    scopus 로고
    • Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy
    • Levin L. A. (1999) Direct and indirect approaches to neuroprotective therapy of glaucomatous optic neuropathy. Surv. Ophthalmol. 43 (Suppl 1), S98-101.
    • (1999) Surv. Ophthalmol. , vol.43 , Issue.SUPPL. 1
    • Levin, L.A.1
  • 20
    • 0033578378 scopus 로고    scopus 로고
    • Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma
    • Neufeld A. H., Sawada A., and Becker B. (1999) Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc. Natl. Acad. Sci. USA 96, 9944-9948.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9944-9948
    • Neufeld, A.H.1    Sawada, A.2    Becker, B.3
  • 21
    • 0027530608 scopus 로고
    • Pattern of glaucomatous neuroretinal rim loss
    • Jonas J. B., Fernandez M. C., and Sturmer J. (1993) Pattern of glaucomatous neuroretinal rim loss. Ophthalmology 100, 63-68.
    • (1993) Ophthalmology , vol.100 , pp. 63-68
    • Jonas, J.B.1    Fernandez, M.C.2    Sturmer, J.3
  • 22
    • 0028905219 scopus 로고
    • Pattern of visual field defects in normal-tension and high-tension glaucoma
    • Araie M. (1995) Pattern of visual field defects in normal-tension and high-tension glaucoma. Curr. Opin. Ophthalmol. 6, 36-45.
    • (1995) Curr. Opin. Ophthalmol. , vol.6 , pp. 36-45
    • Araie, M.1
  • 23
    • 0033777707 scopus 로고    scopus 로고
    • Concordance of parapapillary chorioretinal atrophy inocular hypertension with visual field defects that accompany glaucoma development
    • Tezel G., Dorr D., Kolker A. E., Wax M. B., and Kass M. A. (2000) Concordance of parapapillary chorioretinal atrophy inocular hypertension with visual field defects that accompany glaucoma development. Ophthalmology 107, 1194-1199.
    • (2000) Ophthalmology , vol.107 , pp. 1194-1199
    • Tezel, G.1    Dorr, D.2    Kolker, A.E.3    Wax, M.B.4    Kass, M.A.5
  • 25
    • 0027418959 scopus 로고
    • Foveal ganglion cell loss is size dependent in experimental glaucoma
    • Glovinsky Y., Quigley H. A., and Pease M. E. (1993) Foveal ganglion cell loss is size dependent in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 34, 395-400.
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 395-400
    • Glovinsky, Y.1    Quigley, H.A.2    Pease, M.E.3
  • 26
    • 0029915446 scopus 로고    scopus 로고
    • Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma
    • Dreyer E. B., Zurakowski D., Schumer R. A., Podos S. M., and Lipton S. A. (1996) Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch. Ophthalmol. 114, 299-305.
    • (1996) Arch. Ophthalmol. , vol.114 , pp. 299-305
    • Dreyer, E.B.1    Zurakowski, D.2    Schumer, R.A.3    Podos, S.M.4    Lipton, S.A.5
  • 27
    • 0028332131 scopus 로고
    • Increased incidence of paraproteinemia and autoantibodies in patients with normalpressure glaucoma
    • Wax M. B., Barrett D. A., and Pestronk A. (1994) Increased incidence of paraproteinemia and autoantibodies in patients with normalpressure glaucoma. Am. J. Ophthalmol. 117, 561-568.
    • (1994) Am. J. Ophthalmol. , vol.117 , pp. 561-568
    • Wax, M.B.1    Barrett, D.A.2    Pestronk, A.3
  • 28
    • 0034657707 scopus 로고    scopus 로고
    • The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells
    • Tezel G. and Wax M. B. (2000) The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J. Neurosci. 20, 3552-3562.
    • (2000) J. Neurosci. , vol.20 , pp. 3552-3562
    • Tezel, G.1    Wax, M.B.2
  • 29
    • 0032878142 scopus 로고    scopus 로고
    • Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro
    • Tezel G. and Wax M. B. (1999) Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest. Ophthalmol. Vis. Sci. 40, 2660-2667.
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 2660-2667
    • Tezel, G.1    Wax, M.B.2
  • 30
    • 0034548875 scopus 로고    scopus 로고
    • Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells
    • Tezel G. and Wax M. B. (2000) Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J. Neurosci. 20, 8693-8700.
    • (2000) J. Neurosci. , vol.20 , pp. 8693-8700
    • Tezel, G.1    Wax, M.B.2
  • 31
    • 0034652278 scopus 로고    scopus 로고
    • Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases
    • Finn J. T., Weil M., Archer F., Siman R., Srinivasan A., and Raff M. C. (2000) Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases. J. Neurosci. 20, 1333-1341.
    • (2000) J. Neurosci. , vol.20 , pp. 1333-1341
    • Finn, J.T.1    Weil, M.2    Archer, F.3    Siman, R.4    Srinivasan, A.5    Raff, M.C.6
  • 32
    • 0033231775 scopus 로고    scopus 로고
    • 'Axogenic' and 'somagenic' neurodegenerative diseases: Definitions and therapeutic implications
    • Schwartz M., Yoles E., and Levin L. A. (1999) 'Axogenic' and 'somagenic' neurodegenerative diseases: definitions and therapeutic implications. Mol. Med. Today. 5, 470-473.
    • (1999) Mol. Med. Today , vol.5 , pp. 470-473
    • Schwartz, M.1    Yoles, E.2    Levin, L.A.3
  • 33
    • 0031707125 scopus 로고    scopus 로고
    • Degeneration of spared axons following partial white matter lesion: Implications for optic nerve neuropathies
    • Yoles E. and Schwartz M. (1998) Degeneration of spared axons following partial white matter lesion: implications for optic nerve neuropathies. Exp. Neurol. 153, 1-7.
    • (1998) Exp. Neurol. , vol.153 , pp. 1-7
    • Yoles, E.1    Schwartz, M.2
  • 36
    • 0034118273 scopus 로고    scopus 로고
    • An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma
    • Wang X., Tay S. S., and Ng Y. K. (2000) An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma. Exp. Brain Res. 132, 476-484.
    • (2000) Exp. Brain Res. , vol.132 , pp. 476-484
    • Wang, X.1    Tay, S.S.2    Ng, Y.K.3
  • 37
    • 0036202327 scopus 로고    scopus 로고
    • Immunohistologic evidence for retinal glial cell changes in human glaucoma
    • Wang L., Cioffi G. A., Cull G., Dong J., and Fortune B. (2002) Immunohistologic evidence for retinal glial cell changes in human glaucoma. Invest. Ophthalmol. Vis. Sci. 43, 1088-1094.
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , pp. 1088-1094
    • Wang, L.1    Cioffi, G.A.2    Cull, G.3    Dong, J.4    Fortune, B.5
  • 38
    • 0030896890 scopus 로고    scopus 로고
    • The optic nerve head in glaucomatous optic neuropathy
    • Hernandez M. R. and Pena J. D. (1997) The optic nerve head in glaucomatous optic neuropathy. Arch. Ophthalmol. 115, 389-395.
    • (1997) Arch. Ophthalmol. , vol.115 , pp. 389-395
    • Hernandez, M.R.1    Pena, J.D.2
  • 39
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet J. L., Malhotra S. K., Privat A., and Gage F. H. (1997) Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20, 570-577.
    • (1997) Trends Neurosci. , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 40
    • 0030015429 scopus 로고    scopus 로고
    • Migration of glial cells into retinal axon target field in Drosophila melanogaster
    • Perez S. E. and Steller H. (1996) Migration of glial cells into retinal axon target field in Drosophila melanogaster. J. Neurobiol. 30, 359-373.
    • (1996) J. Neurobiol. , vol.30 , pp. 359-373
    • Perez, S.E.1    Steller, H.2
  • 41
    • 0033779559 scopus 로고    scopus 로고
    • Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
    • Anderson C. M. and Swanson R. A. (2000) Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32, 1-14.
    • (2000) Glia , vol.32 , pp. 1-14
    • Anderson, C.M.1    Swanson, R.A.2
  • 42
    • 0033779517 scopus 로고    scopus 로고
    • Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death
    • Vorwerk C. K., Naskar R., Schuettauf P., Quinto K., Zurakowski D., Gochenauer G., et al. (2000) Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. Invest. Ophthalmol Vis. Sci. 41, 3615-3621.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 3615-3621
    • Vorwerk, C.K.1    Naskar, R.2    Schuettauf, P.3    Quinto, K.4    Zurakowski, D.5    Gochenauer, G.6
  • 43
    • 0034128172 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head
    • Yan X., Tezel G., Wax M. B., and Edward D. P. (2000) Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch. Ophthalmol. 118, 666-673.
    • (2000) Arch. Ophthalmol. , vol.118 , pp. 666-673
    • Yan, X.1    Tezel, G.2    Wax, M.B.3    Edward, D.P.4
  • 44
    • 0035101187 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes
    • Agapova O. A., Ricard C. S., Salvador-Silva M., and Hernandez M. R. (2001) Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia 33, 205-216.
    • (2001) Glia , vol.33 , pp. 205-216
    • Agapova, O.A.1    Ricard, C.S.2    Salvador-Silva, M.3    Hernandez, M.R.4
  • 45
    • 0033997806 scopus 로고    scopus 로고
    • The optic nerve headin glaucoma: Role of astrocytes in tissue remodeling
    • Hernandez M. R. (2000) The optic nerve headin glaucoma: role of astrocytes in tissue remodeling. Prog. Retin Eye Res. 19, 297-321.
    • (2000) Prog. Retin Eye Res. , vol.19 , pp. 297-321
    • Hernandez, M.R.1
  • 46
    • 0035009838 scopus 로고    scopus 로고
    • In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head
    • Tezel G., Hernandez M. R., and Wax M. B. (2001) In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head. Glia 34, 178-189.
    • (2001) Glia , vol.34 , pp. 178-189
    • Tezel, G.1    Hernandez, M.R.2    Wax, M.B.3
  • 47
    • 0030971499 scopus 로고    scopus 로고
    • Nitric oxide synthase in the human glaucomatous optic nerve head
    • Neufeld A. H., Hernandez M. R., and Gonzalez M. (1997) Nitric oxide synthase in the human glaucomatous optic nerve head. Arch. Ophthalmol. 115, 497-503.
    • (1997) Arch. Ophthalmol. , vol.115 , pp. 497-503
    • Neufeld, A.H.1    Hernandez, M.R.2    Gonzalez, M.3
  • 48
    • 0033781980 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha: A potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head
    • Yuan L. and Neufeld A. H. (2000) Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 32, 42-50.
    • (2000) Glia , vol.32 , pp. 42-50
    • Yuan, L.1    Neufeld, A.H.2
  • 49
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    • Yuan J., Shaham S., Ledoux S., Ellis H. M., and Horvitz H. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75, 641-652.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 50
    • 0028102478 scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik Y. A., Kaufmann S. H., Desnoyers S., Poirier G. G., and Earnshaw W. C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.
    • (1994) Nature , vol.371 , pp. 346-347
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earnshaw, W.C.5
  • 51
    • 0029007855 scopus 로고
    • The TNF receptor 1-associated protein TRADD signals cell death and NF- kappa B activation
    • Hsu H., Xiong J., and Goeddel D. V. (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF- kappa B activation. Cell 81, 495-504.
    • (1995) Cell , vol.81 , pp. 495-504
    • Hsu, H.1    Xiong, J.2    Goeddel, D.V.3
  • 52
    • 0027973061 scopus 로고
    • CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta- converting enzyme
    • Fernandes-Alnemri T., Litwack G., and Alnemri E. S. (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta- converting enzyme. J. Biol. Chem. 269, 30761-30764.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30761-30764
    • Fernandes-Alnemri, T.1    Litwack, G.2    Alnemri, E.S.3
  • 53
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement fordATP and cytochrome c
    • Liu X., Kim C. N., Yang J., Jemmerson R., and Wang X. (1996) Induction of apoptotic program in cell-free extracts: requirement fordATP and cytochrome c. Cell 86, 147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 54
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H., Henzel W. J., Liu X., Lutschg A., and Wang X. (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 55
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c- myc to immortalize pre-B cells
    • Vaux D. L., Cory S., and Adams J. M. (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c- myc to immortalize pre-B cells. Nature 335, 440-442.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 57
  • 58
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck R. M., Bossy-Wetzel E., Green D. R., and Newmeyer D. D. (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275, 1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 59
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P., Nijhawan D., Budihardjo I., Srinivasula S. M., Ahmad M., Alnemri E. S., and Wang X. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 60
    • 0028990125 scopus 로고
    • Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
    • Tewari M., Quan L. T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D. R., et al. (1995) Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81, 801-809.
    • (1995) Cell , vol.81 , pp. 801-809
    • Tewari, M.1    Quan, L.T.2    O'Rourke, K.3    Desnoyers, S.4    Zeng, Z.5    Beidler, D.R.6
  • 61
    • 0030008918 scopus 로고    scopus 로고
    • Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic micg overexpressing bcl-2
    • Bonfanti L., Strettoi E., Chierzi S., Cenni M. C., Liu X. H., Martinou J. C., et al. (1996) Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic micg overexpressing bcl-2. J. Neurosci. 16, 4186-4194.
    • (1996) J. Neurosci. , vol.16 , pp. 4186-4194
    • Bonfanti, L.1    Strettoi, E.2    Chierzi, S.3    Cenni, M.C.4    Liu, X.H.5    Martinou, J.C.6
  • 63
    • 0032724840 scopus 로고    scopus 로고
    • Density-dependent resistance to apoptosis in retinal cells
    • Tezel G. M., Seigel G. M., and Wax M. B. (1999) Density-dependent resistance to apoptosis in retinal cells. Curr. Eye Res. 19, 377-388.
    • (1999) Curr. Eye Res. , vol.19 , pp. 377-388
    • Tezel, G.M.1    Seigel, G.M.2    Wax, M.B.3
  • 64
    • 0033387525 scopus 로고    scopus 로고
    • Structure and function in the p53 family
    • Arrowsmith C. H. (1999) Structure and function in the p53 family. Cell Death Differ. 6, 1169-1173.
    • (1999) Cell Death Differ. , vol.6 , pp. 1169-1173
    • Arrowsmith, C.H.1
  • 65
    • 0033375769 scopus 로고    scopus 로고
    • Role of p53 and apoptosis in carcinogenesis
    • Wang X. W. (1999) Role of p53 and apoptosis in carcinogenesis. Anticancer Res. 19, 4759-4771.
    • (1999) Anticancer Res. , vol.19 , pp. 4759-4771
    • Wang, X.W.1
  • 66
    • 0032797074 scopus 로고    scopus 로고
    • Apoptosis of retinal ganglion cells in glaucoma: An update of the molecular pathways involved in cell death
    • Nickells R. W. (1999) Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death. Surv. Ophthalmol. 43 Suppl 1, S151-161.
    • (1999) Surv. Ophthalmol. , vol.43 , Issue.SUPPL. 1
    • Nickells, R.W.1
  • 68
    • 0034757151 scopus 로고    scopus 로고
    • Maintaining mitochondrial membrane impermeability, an opportunity for new therapy in glaucoma?
    • Tatton W. G., Chalmers-Redman R. M., Sud A., Podos S. M., and Mittag T. W. (2001) Maintaining mitochondrial membrane impermeability, an opportunity for new therapy in glaucoma? Surv. Ophthalmol. 45 Suppl 3, S277-283.
    • (2001) Surv. Ophthalmol. , vol.45 , Issue.SUPPL. 3
    • Tatton, W.G.1    Chalmers-Redman, R.M.2    Sud, A.3    Podos, S.M.4    Mittag, T.W.5
  • 70
    • 0034934110 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and its receptor-1 in the retina of normal and glaucomatous eyes
    • Tezel G., Li L. Y., Patil R. V., and Wax M. B. (2001) Tumor necrosis factor-alpha and its receptor-1 in the retina of normal and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 1787-1794.
    • (2001) Invest. Ophthalmol. Vis. Sci. , pp. 1787-1794
    • Tezel, G.1    Li, L.Y.2    Patil, R.V.3    Wax, M.B.4
  • 71
    • 18244385269 scopus 로고    scopus 로고
    • Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    • Rezaie T., Child A., Hitchings R., Brice G., Miller L., Coca-Prados M., et al. (2002) Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 295, 1077-1079.
    • (2002) Science , vol.295 , pp. 1077-1079
    • Rezaie, T.1    Child, A.2    Hitchings, R.3    Brice, G.4    Miller, L.5    Coca-Prados, M.6
  • 72
    • 0033979815 scopus 로고    scopus 로고
    • Roles of nuclear factor kappaB in neuronal survival and plasticity
    • Mattson M. P., Culmsee C., Yu Z., and Camandola S. (2000) Roles of nuclear factor kappaB in neuronal survival and plasticity. J. Neurochem. 74, 443-456.
    • (2000) J. Neurochem. , vol.74 , pp. 443-456
    • Mattson, M.P.1    Culmsee, C.2    Yu, Z.3    Camandola, S.4
  • 73
    • 0033026165 scopus 로고    scopus 로고
    • Signalling by CD95 and TNF receptors: Not only life and death
    • Magnusson C. and Vaux D. L. (1999) Signalling by CD95 and TNF receptors: not only life and death. Immunol. Cell Biol. 77, 41-46.
    • (1999) Immunol. Cell Biol. , vol.77 , pp. 41-46
    • Magnusson, C.1    Vaux, D.L.2
  • 74
    • 0025873365 scopus 로고
    • Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP
    • Saklatvala J., Kaur P., and Guesdon F. (1991) Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP. Biochem. J. 277, 635-642.
    • (1991) Biochem. J. , vol.277 , pp. 635-642
    • Saklatvala, J.1    Kaur, P.2    Guesdon, F.3
  • 75
    • 0024368411 scopus 로고
    • Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells
    • Kaur P., Welch W. J., and Saklatvala J. (1989) Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells. FEBS Lett. 258, 269-273.
    • (1989) FEBS Lett. , vol.258 , pp. 269-273
    • Kaur, P.1    Welch, W.J.2    Saklatvala, J.3
  • 76
    • 0029939244 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes
    • Nakano M., Knowlton A. A., Yokoyama T., Lesslauer W., and Mann D. L. (1996) Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes. Am. J. Physiol. 270, H1231-1239.
    • (1996) Am. J. Physiol. , vol.270
    • Nakano, M.1    Knowlton, A.A.2    Yokoyama, T.3    Lesslauer, W.4    Mann, D.L.5
  • 78
    • 0032798811 scopus 로고    scopus 로고
    • Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma
    • Tezel G., Edward D. P., and Wax M. B. (1999) Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma. Arch. Ophthalmol. 117, 917-924.
    • (1999) Arch. Ophthalmol. , vol.117 , pp. 917-924
    • Tezel, G.1    Edward, D.P.2    Wax, M.B.3
  • 79
  • 80
    • 0032006268 scopus 로고    scopus 로고
    • Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma
    • Wax M. B., Tezel G., Saito I., Gupta R. S., Harley J. B., Li Z., and Romano C. (1998) Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma. Am. J. Ophthalmol. 125, 145-157.
    • (1998) Am. J. Ophthalmol. , vol.125 , pp. 145-157
    • Wax, M.B.1    Tezel, G.2    Saito, I.3    Gupta, R.S.4    Harley, J.B.5    Li, Z.6    Romano, C.7
  • 81
    • 0031789541 scopus 로고    scopus 로고
    • Autoantibodies to small heat shock proteins in glaucoma
    • Tezel G., Seigel G. M., and Wax M. B. (1998) Autoantibodies to small heat shock proteins in glaucoma. Invest. Ophthalmol. Vis. Sci. 39, 2277-2287.
    • (1998) Invest. Ophthalmol. Vis. Sci. , vol.39 , pp. 2277-2287
    • Tezel, G.1    Seigel, G.M.2    Wax, M.B.3
  • 82
    • 0034083161 scopus 로고    scopus 로고
    • Retinal ganglion cells recognized by serum autoantibody against gamma- enolase found in glaucoma patients
    • Maruyama I., Ohguro H., and Ikeda Y. (2000) Retinal ganglion cells recognized by serum autoantibody against gamma- enolase found in glaucoma patients. Invest. Ophthalmol. Vis. Sci. 41, 1657-1665.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 1657-1665
    • Maruyama, I.1    Ohguro, H.2    Ikeda, Y.3
  • 83
    • 0035032389 scopus 로고    scopus 로고
    • Serum autoantibody against glutathione S-transferase in patients with glaucoma
    • Yang J., Tezel G., Patil R. V., Romano C., and Wax M. B. (2001) Serum autoantibody against glutathione S-transferase in patients with glaucoma. Invest. Ophthalmol. Vis. Sci. 42, 1273-1276.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 1273-1276
    • Yang, J.1    Tezel, G.2    Patil, R.V.3    Romano, C.4    Wax, M.B.5
  • 84
    • 0032948104 scopus 로고    scopus 로고
    • Epitope mapping of antirhodopsin antibodies from patients with normal pressure glaucoma
    • Romano C., Li Z., Arendt A., Hargrave P. A., and Wax M. B. (1999) Epitope mapping of antirhodopsin antibodies from patients with normal pressure glaucoma. Invest. Ophthalmol. Vis. Sci. 40, 1275-1280.
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 1275-1280
    • Romano, C.1    Li, Z.2    Arendt, A.3    Hargrave, P.A.4    Wax, M.B.5
  • 85
    • 0032809910 scopus 로고    scopus 로고
    • Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma
    • Neufeld A. H. (1999) Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma. Arch. Ophthalmol. 117, 1050-1056.
    • (1999) Arch. Ophthalmol. , vol.117 , pp. 1050-1056
    • Neufeld, A.H.1
  • 86
    • 0035142571 scopus 로고    scopus 로고
    • Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia
    • Yang J., Yang P., Tezel G., Patil R. V., Hernandez M. R., and Wax M. B. (2001) Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia. Invest. Ophthalmol. Vis. Sci. 42, 365-371.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 365-371
    • Yang, J.1    Yang, P.2    Tezel, G.3    Patil, R.V.4    Hernandez, M.R.5    Wax, M.B.6
  • 87
    • 0035062239 scopus 로고    scopus 로고
    • T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma
    • Yang J., Patil R. V., Yu H., Gordon M., and Wax M. B. (2001) T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma. Am. J. Ophthalmol. 131, 421-426.
    • (2001) Am. J. Ophthalmol. , vol.131 , pp. 421-426
    • Yang, J.1    Patil, R.V.2    Yu, H.3    Gordon, M.4    Wax, M.B.5
  • 88
    • 0034966787 scopus 로고    scopus 로고
    • Protective autoimmunity: Regulation and prospects for vaccination after brain and spinal cord injuries
    • Schwartz M. and Kipnis J. (2001) Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries. Trends Mol. Med. 7, 252-258.
    • (2001) Trends Mol. Med. , vol.7 , pp. 252-258
    • Schwartz, M.1    Kipnis, J.2
  • 89
    • 0035370214 scopus 로고    scopus 로고
    • Protective autoimmunity is a physiological response to CNS trauma
    • Yoles E., Hauben E., Palgi O., Agranov E., Gothilf A., Cohen A., et al. (2001) Protective autoimmunity is a physiological response to CNS trauma. J. Neurosci. 21, 3740-3748.
    • (2001) J. Neurosci. , vol.21 , pp. 3740-3748
    • Yoles, E.1    Hauben, E.2    Palgi, O.3    Agranov, E.4    Gothilf, A.5    Cohen, A.6
  • 90
    • 0345073285 scopus 로고    scopus 로고
    • Bcl-2 and Hsp27 act at different levels to suppress programmed cell death
    • Guenal I., Sidoti-de Fraisse C., Gaumer S., and Mignotte B. (1997) Bcl-2 and Hsp27 act at different levels to suppress programmed cell death. Oncogene 15, 347-360.
    • (1997) Oncogene , vol.15 , pp. 347-360
    • Guenal, I.1    Sidoti-de Fraisse, C.2    Gaumer, S.3    Mignotte, B.4
  • 91
    • 0034071397 scopus 로고    scopus 로고
    • Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes
    • Tezel G., Hernandez M. R., and Wax M. B. (2000) Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch. Ophthalmol. 118, 511-518.
    • (2000) Arch. Ophthalmol. , vol.118 , pp. 511-518
    • Tezel, G.1    Hernandez, M.R.2    Wax, M.B.3
  • 92
    • 0034969202 scopus 로고    scopus 로고
    • Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model
    • Park K. H., Cozier F., Ong O. C., and Caprioli J. (2001) Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 42, 1522-1530.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 1522-1530
    • Park, K.H.1    Cozier, F.2    Ong, O.C.3    Caprioli, J.4
  • 93
    • 0028229757 scopus 로고
    • Differential induction of mRNA species encoding several classes of stress proteins following focal cerebral ischemia in rats
    • Higashi T., Takechi H., Uemura Y., Kikuchi H., and Nagata K. (1994) Differential induction of mRNA species encoding several classes of stress proteins following focal cerebral ischemia in rats. Brain Res. 650, 239-248.
    • (1994) Brain Res. , vol.650 , pp. 239-248
    • Higashi, T.1    Takechi, H.2    Uemura, Y.3    Kikuchi, H.4    Nagata, K.5
  • 94
    • 0032192097 scopus 로고    scopus 로고
    • Induction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury
    • Hopkins D. A., Plumier J. C., and Currie R. W. (1998) Induction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury. Exp. Neurol. 153, 173-183.
    • (1998) Exp. Neurol. , vol.153 , pp. 173-183
    • Hopkins, D.A.1    Plumier, J.C.2    Currie, R.W.3
  • 95
    • 0032146734 scopus 로고    scopus 로고
    • Heat shock protein 27: Developmental regulation and expression after peripheral nerve injury
    • Costigan M., Mannion R. J., Kendall G., Lewis S. E., Campagna J. A., Coggeshall R. E., et al. (1998) Heat shock protein 27: developmental regulation and expression after peripheral nerve injury. J. Neurosci. 18, 5891-5900.
    • (1998) J. Neurosci. , vol.18 , pp. 5891-5900
    • Costigan, M.1    Mannion, R.J.2    Kendall, G.3    Lewis, S.E.4    Campagna, J.A.5    Coggeshall, R.E.6
  • 96
    • 0029933741 scopus 로고    scopus 로고
    • Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death
    • Mehlen P., Kretz-Remy C., Preville X., and Arrigo A. P. (1996) Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. EMBO J. 15, 2695-2706.
    • (1996) EMBO J. , vol.15 , pp. 2695-2706
    • Mehlen, P.1    Kretz-Remy, C.2    Preville, X.3    Arrigo, A.P.4
  • 97
    • 0030014643 scopus 로고    scopus 로고
    • Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death
    • Mehlen P., Schulze-Osthoff K., and Arrigo A. P. (1996) Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death. J. Biol. Chem. 271, 16510-16514.
    • (1996) J. Biol. Chem. , vol.271 , pp. 16510-16514
    • Mehlen, P.1    Schulze-Osthoff, K.2    Arrigo, A.P.3
  • 98
    • 0007404243 scopus 로고    scopus 로고
    • Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells
    • Mehlen P., Hickey E., Weber L. A., and Arrigo A. P. (1997) Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells. Biochem. Biophys. Res. Commun. 241, 187-192.
    • (1997) Biochem. Biophys. Res. Commun. , vol.241 , pp. 187-192
    • Mehlen, P.1    Hickey, E.2    Weber, L.A.3    Arrigo, A.P.4
  • 99
    • 0031961844 scopus 로고    scopus 로고
    • Overexpression of HSP25 reduces the level of TNF alpha-induced oxidative DNA damage biomarker, 8-hydroxy-2′-deoxyguanosine, in L929 cells
    • Park Y. M., Han M. Y., Blackburn R. V., and Lee Y. J. (1998) Overexpression of HSP25 reduces the level of TNF alpha-induced oxidative DNA damage biomarker, 8-hydroxy-2′-deoxyguanosine, in L929 cells. J. Cell Physiol. 174, 27-34.
    • (1998) J. Cell Physiol. , vol.174 , pp. 27-34
    • Park, Y.M.1    Han, M.Y.2    Blackburn, R.V.3    Lee, Y.J.4
  • 100
    • 0034054731 scopus 로고    scopus 로고
    • Role of small heat shock protein HSP25 in radioresistance and glutathione-redox cycle
    • Baek S. H., Min J. N., Park E. M., Han M. Y., Lee Y. S., Lee Y. J., and Park Y. M. (2000) Role of small heat shock protein HSP25 in radioresistance and glutathione-redox cycle. J. Cell Physiol. 183, 100-107.
    • (2000) J. Cell Physiol. , vol.183 , pp. 100-107
    • Baek, S.H.1    Min, J.N.2    Park, E.M.3    Han, M.Y.4    Lee, Y.S.5    Lee, Y.J.6    Park, Y.M.7
  • 101
    • 0029849821 scopus 로고    scopus 로고
    • Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity
    • Caprioli J., Kitano S., and Morgan J. E. (1996) Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity. Invest. Ophthalmol. Vis. Sci. 37, 2376-2381.
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 2376-2381
    • Caprioli, J.1    Kitano, S.2    Morgan, J.E.3
  • 102
    • 0026793261 scopus 로고
    • Heat-shock proteins: Immunity and autoimmunity
    • Young D. B. (1992) Heat-shock proteins: immunity and autoimmunity. Curr. Opin. Immunol. 4, 396-400.
    • (1992) Curr. Opin. Immunol. , vol.4 , pp. 396-400
    • Young, D.B.1


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