Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABAA receptors with the activation of G-protein-coupled receptors

Journal of Neuroscience

Volumn 22, Issue 15, 2002, Pages 6353-6361

  Brandon, Nicholas J ^a   Jovanovic, Jasmina N ^a   Smart, Trevor G ^b   Moss, Stephen J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cross talk; GABAA receptor; GST fusion protein; Muscarinic receptor phosphorylation; Protein kinase C; Receptor for activated C kinase

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MUSCARINIC RECEPTOR; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN RACK 1; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BETA CHAIN; BINDING SITE; BRAIN; NERVE CELL; NERVE EXCITABILITY; NEUROTRANSMISSION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SYNAPTIC INHIBITION;

EID: 0036703626     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-15-06353.2002     Document Type: Article

References (43)

1. Benke D, Fritschy JM, Trzeciak A, Bannwarth W, Mohler H (1994) Distribution, prevalence, and drug binding profile of γ-aminobutyric acid type A receptor subtypes differing in the β-subunit variant. J Biol Chem 269:27100-27107.
2. C receptor sensitivity is modulated by interaction with MAP1B. J Neurosci 20:8643-8650.
3. Bonnert TP, McKernan RM, Farrar S, le Bourdelles B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (1999) Theta, a novel γ-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci USA 96:9891-9896.
4. Brandon NJ, Uren JM, Kittler JT, Wang H, Olsen R, Parker PJ, Moss SJ (1999) Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. J Neurosci 19:9228-9234.
5. A receptors by protein phosphorylation. In: GABA in the Nervous System, the View at 50 Years (Martin DL, Olsen RL, eds), pp 191-206. Baltimore: Williams & Wilkins.
6. A receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. J Biol Chem 275:38856-38862.
7. A receptor γ2 subunit in rat brain. Neuropharmacology 41:745-752.
8. Brown DA, Abogadie FC, Allen TG, Buckley NJ, Caulfield MP, Delmas P, Haley JE, Lamas JA, Selyanko AA (1997) Muscarinic mechanisms in nerve cells. Life Sci 60:1137-1144.
9. A receptor. Proc Natl Acad Sci USA 87:1315-1318.
10. A receptors. Proc Natl Acad Sci USA 96:2456-2460.
11. Chang BY, Conroy KB, Machleder EM, Cartwright CA (1998) RACK-1, a receptor for activated C kinase and a homolog of the beta subunit of G-proteins, inhibits activity of Src tyrosine kinases and growth of NIH 3T3 cells. Mol Cell Biol 18:3245-3256.
12. Chapell R, Bueno OF, Alvarez-Hernandez X, Robinson LC, Leidenheimer NJ (1978) Activation of protein kinase C induces γaminobutyric acid type A receptor internalization in Xenopus oocytes. J Biol Chem 273:32595-32601.
13. A receptors. J Biol Chem 271:89-96.
14. A receptor subunit. Nature 385:820-823.
15. A receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J Neurosci 21:6502-6511.
16. Fraser IDC, Scott JD (1999) Modulation of ion channels: A current view of AKAPs. Neuron 23:423-426.
17. q contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons. J Neurosci 18:4521-4523.
18. Jaken S, Parker PJ (2000) Protein kinase C binding partners. BioEssays 22:245-254.
19. A receptor β3 subunit. Soc Neurosci Abstr 27:522.1.
20. Kellenberger S, Malherbe P, Sigel E (1992) Function of the α1β2γ2S γ-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. J Biol Chem 267:25660-25663.
21. A receptor function by protein kinase C phosphorylation. Neuron 12:1081-1095.
22. Lees GM (1986) Anatomy, histology, and electron microscopy of sympathetic, parasympathetic, and enteric neurons. In: Autonomic and Enteric Ganglia. Transmission and its Pharmacology (Karczmar AG, Koketsu K, Nishi S, eds), pp 27-60. New York: Plenum.
23. Levitan IB (1999) Modulation of ion channels by protein phosphorylation. How the brain works. Adv Second Messenger Phosphoprotein Res 33:3-22.
24. Liliental J, Chang DD (1998) RACK-1, a receptor for activated protein kinase C, interacts with integrin β subunit. J Biol Chem 273:2379-2383.
25. A receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both β1 and γ2L subunits. Mol Pharmacol 50:185-195.
26. 2+/calmodulin type II-dependent protein kinase. Neuropharmacology 36:1377-1385.
27. A receptor β subunits determine regulation by cAMP-dependent protein kinase. Nat Neurosci 1:23-28.
28. Moss SJ, Smart TG (2001) Constructing inhibitory synapses. Nat Neurosci Rev 2:241-250.
29. A receptor. J Biol Chem 267:14470-14476.
30. A receptors by cAMP-dependent protein phosphorylation. Science 257:661-665.
31. A receptor function by tyrosine phosphorylation. Nature 377:344-348,
32. A receptor function by PKA and PKC in adult hippocampal neurons. J Neurosci 19:674-683.
33. A receptor subunit for benzodiazepine pharmacology. Nature 338:582-585.
34. A receptor research. Synapse 21:189-274.
35. Ron D, Chen C-H, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (1994) Cloning of an intracellular receptor for protein kinase C: A homolog of the β subunits of the G-proteins. Proc Natl Acad Sci USA 91:839-843.
36. Ron D, Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (1999) Coordinated movement of RACK-1 with activated βII PKC. J Biol Chem 274:27039-27046.
37. Smith DB, Johnson KS (1988) Single step purification of polypeptides expressed in E. coli as fusions with glutathione S-transferase. Gene 67:31-40.
38. Swope SL, Huganir RL (1993) Molecular cloning of two abundant protein tyrosine kinases in Torpedo electric organ that associate with the acetylcholine receptor. J Biol Chem 268:25152-25161.
39. A receptor subtype. J Neurosci 17:2728-2737.
40. Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser IDC, Langeberg LK, Sheng M, Scott JD (1999) Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285:93-96.
41. Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB (1999) The RACK-1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform. J Biol Chem 274:14909-14917.
42. A receptor β subunit heterogeneity: Functional expression of cloned cDNAs. EMBO J 8:1665-1670.
43. Yu X-M, Askalan R, Keil GJ, Salter MW (1997) NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 275: 674-676.