Inhibition of human mesenchymal stem cell-derived adipogenesis by the environmental contaminant benzo(a)pyrene

Toxicology in Vitro

Volumn 23, Issue 6, 2009, Pages 1139-1144

  Podechard, Normand ^a   Fardel, Olivier ^a,b   Corolleur, Michel ^b   Bernard, Marc ^b   Lecureur, Valérie ^a  

^a INSERM   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

Adipogenesis; Aryl hydrocarbon receptor; Benzo(a)pyrene; Mesenchymal stem cell; Polycyclic aromatic hydrocarbons

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; FATTY ACID BINDING PROTEIN 4; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ECOTOXICOLOGY; HUMAN; HUMAN CELL; LIPID STORAGE; LIPID VESICLE; MESENCHYMAL STEM CELL; UPREGULATION;

ADIPOGENESIS; BENZO(A)PYRENE; CELL DIFFERENTIATION; CELLS, CULTURED; ENVIRONMENTAL POLLUTANTS; FATTY ACID-BINDING PROTEINS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; MESENCHYMAL STEM CELLS; POLYCYCLIC HYDROCARBONS, AROMATIC; RECEPTORS, ARYL HYDROCARBON; UP-REGULATION;

RODENTIA;

EID: 68149099006     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.05.011     Document Type: Article

References (30)

1. Albanes D., Jones D.Y., Micozzi M.S., and Mattson M.E. Associations between smoking and body weight in the US population: analysis of NHANES II. American Journal of Public Health 77 (1987) 439-444
2. Alexander D.L., Ganem L.G., Fernandez-Salguero P., Gonzalez F., and Jefcoate C.R. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. Journal of Cell Science 111 Pt 22 (1998) 3311-3322
3. Borgerding M., and Klus H. Analysis of complex mixtures - cigarette smoke. Experimental and Toxicologic Pathology 57 Suppl. 1 (2005) 43-73
4. Chen H., Hansen M.J., Jones J.E., Vlahos R., Bozinovski S., Anderson G.P., and Morris M.J. Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y-axis to promote weight loss. American Journal of Respiratory and Critical Care Medicine 173 (2006) 1248-1254
5. Chen H., Vlahos R., Bozinovski S., Jones J., Anderson G.P., and Morris M.J. Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice. Neuropsychopharmacology 30 (2005) 713-719
6. Dertinger S.D., Nazarenko D.A., Silverstone A.E., and Gasiewicz T.A. Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene-and cigarette smoke condensate-induced cytogenetic damage in vivo. Carcinogenesis 22 (2001) 171-177
7. Grun F., and Blumberg B. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology 147 (2006) S50-S55
8. Hattemer-Frey H.A., and Travis C.C. Benzo-a-pyrene: environmental partitioning and human exposure. Toxicology and Industrial Health 7 (1991) 141-157
9. Irigaray P., Ogier V., Jacquenet S., Notet V., Sibille P., Mejean L., Bihain B.E., and Yen F.T. Benzo[a]pyrene impairs beta-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice. A novel molecular mechanism of toxicity for a common food pollutant. The FEBS Journal 273 (2006) 1362-1372
10. Lecureur V., Ferrec E.L., N'Diaye M., Vee M.L., Gardyn C., Gilot D., and Fardel O. ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages. FEBS Letters 579 (2005) 1904-1910
11. Li W., Vogel C.F., Fujiyoshi P., and Matsumura F. Development of a human adipocyte model derived from human mesenchymal stem cells (hMSC) as a tool for toxicological studies on the action of TCDD. Biological Chemistry 389 (2008) 169-177
12. Ma Q., and Baldwin K.T. 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway. Role of the transcription activaton and DNA binding of AhR. The Journal of Biological Chemistry 275 (2000) 8432-8438
13. Machala M., Vondracek J., Blaha L., Ciganek M., and Neca J.V. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. Mutation Research 497 (2001) 49-62
14. Mackay D.L., Tesar P.J., Liang L.N., and Haynesworth S.E. Characterizing medullary and human mesenchymal stem cell-derived adipocytes. Journal of Cellular Physiology 207 (2006) 722-728
15. Mullerova D., and Kopecky J. White adipose tissue: storage and effector site for environmental pollutants. Physiological Research/Academia Scientiarum Bohemoslovaca 56 (2007) 375-381
16. Nakamura T., Shiojima S., Hirai Y., Iwama T., Tsuruzoe N., Hirasawa A., Katsuma S., and Tsujimoto G. Temporal gene expression changes during adipogenesis in human mesenchymal stem cells. Biochemical and Biophysical Research Communications 303 (2003) 306-312
17. Nebert D.W., Dalton T.P., Okey A.B., and Gonzalez F.J. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. The Journal of Biological Chemistry 279 (2004) 23847-23850
18. Park B.H., Qiang L., and Farmer S.R. Phosphorylation of C/EBPbeta at a consensus extracellular signal-regulated kinase/glycogen synthase kinase 3 site is required for the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes. Molecular and Cellular Biology 24 (2004) 8671-8680
19. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., and Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
20. Rodgman A., Smith C.J., and Perfetti T.A. The composition of cigarette smoke: a retrospective, with emphasis on polycyclic components. Human and Experimental Toxicology 19 (2000) 573-595
21. Rosen E.D. The transcriptional basis of adipocyte development. Prostaglandins, Leukotrienes, and Essential Fatty Acids 73 (2005) 31-34
22. Shimada T., Hiramatsu N., Hayakawa K., Takahashi S., Kasai A., Tagawa Y., Mukai M., Yao J., Fujii-Kuriyama Y., and Kitamura M. Dual suppression of adipogenesis by cigarette smoke through activation of the aryl hydrocarbon receptor and induction of endoplasmic reticulum stress. American Journal of Physiology, Endocrinology and Metabolism 296 (2009) E721-730
23. Shimada T., Hiramatsu N., Kasai A., Mukai M., Okamura M., Yao J., Huang T., Tamai M., Takahashi S., Nakamura T., and Kitamura M. Suppression of adipocyte differentiation by Cordyceps militaris through activation of the aryl hydrocarbon receptor. American Journal of Physiology, Endocrinology and Metabolism 295 (2008) E859-867
24. Shimba S., Todoroki K., Aoyagi T., and Tezuka M. Depletion of arylhydrocarbon receptor during adipose differentiation in 3T3-L1 cells. Biochemical and Biophysical Research Communications 249 (1998) 131-137
25. Shimba S., Wada T., and Tezuka M. Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin. Journal of Cell Science 114 (2001) 2809-2817
26. Shimizu Y., Nakatsuru Y., Ichinose M., Takahashi Y., Kume H., Mimura J., Fujii-Kuriyama Y., and Ishikawa T. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences of the United States of America 97 (2000) 779-782
27. Swauger J.E., Steichen T.J., Murphy P.A., and Kinsler S. An analysis of the mainstream smoke chemistry of samples of the US cigarette market acquired between 1995 and 2000. Regulatory Toxicology and Pharmacology 35 (2002) 142-156
28. van Grevenynghe J., Bernard M., Langouet S., Le Berre C., Fest T., and Fardel O. Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons. The Journal of Pharmacology, and Experimental Therapeutics 314 (2005) 693-702
29. van Grevenynghe J., Rion S., Le Ferrec E., Le Vee M., Amiot L., Fauchet R., and Fardel O. Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages. The Journal of Immunology 170 (2003) 2374-2381
30. Wager-Srdar S.A., Levine A.S., Morley J.E., Hoidal J.R., and Niewoehner D.E. Effects of cigarette smoke and nicotine on feeding and energy. Physiology and Behavior 32 (1984) 389-395