Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors

Neuropharmacology

Volumn 56, Issue 1, 2009, Pages 114-120

  Plested, Andrew J R ^a   Mayer, Mark L ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Calcium; Cation binding site; Glutamate receptor; Magnesium

Indexed keywords

CALCIUM; DIVALENT CATION; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; MAGNESIUM; SODIUM ION;

ALLOSTERISM; ARTICLE; BINDING SITE; CELL STRAIN HEK293; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; LIGAND BINDING; MUTATION; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ENGINEERING; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; STEREOSPECIFICITY;

ALLOSTERIC SITE; ASPARTIC ACID; BINDING SITES; CATIONS, DIVALENT; CELL LINE, TRANSFORMED; GENETIC ENGINEERING; HUMANS; METHIONINE; MODELS, MOLECULAR; MUTATION; RECEPTORS, KAINIC ACID; TRANSFECTION;

EID: 58049192996     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.07.013     Document Type: Article

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