Induced pluripotent stem cells: Reprogrammed without a trace

Regenerative Medicine

Volumn 4, Issue 3, 2009, Pages 333-335

  Nelson, Timothy J ^a   Terzic, Andre ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; RETROVIRUS VECTOR;

CELL DIFFERENTIATION; CELL INTERACTION; CELL TRANSFER; DNA SEQUENCE; EDITORIAL; GENE INTERACTION; GENE TARGETING; GENOTYPE ENVIRONMENT INTERACTION; HIGH THROUGHPUT SCREENING; NUCLEAR REPROGRAMMING; PHENOTYPE; PLASMID; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SOMATIC CELL; TISSUE ENGINEERING; TRANSPOSON; ANIMAL; CYTOLOGY; HUMAN; METABOLISM; METHODOLOGY; REGENERATIVE MEDICINE;

ANIMALS; CELL DIFFERENTIATION; HUMANS; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELLS; REGENERATIVE MEDICINE;

EID: 68049137797     PISSN: 17460751     EISSN: None     Source Type: Journal    
DOI: 10.2217/rme.09.16     Document Type: Editorial

References (30)

1. Campbell KHS, McWhir J, Ritchie WA et al.: Sheep cloned by nuclear transfer from a cultured cell line. Nature 380, 64-66 (1996).
2. Wilmut I, Schnieke AE, McWhir J et al.: Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810-813 (1997).
3. Hochedlinger K, Jaenisch R: Nuclear reprogramming and pluripotency. Nature 441, 1061-1067 (2006).
4. Armstrong L, Lako M, Dean W et al.: Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer. Stem Cells 24, 805-814 (2006).
5. Beyhan Z, Iager AE, Cibelli JB: Interspecies nuclear transfer: implications for embryonic stem cell biology. Cell Stem Cell 1, 502-512 (2007).
6. Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
7. Okita K, Ichisaka T, Yamanaka S: Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317 (2007).
8. Maherali N, Hochedlinger K: Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell 3, 595-605 (2008).
9. Smith KP, Luong MX, Stein GS: Pluripotency: toward a gold standard for human ES and iPS cells. J. Cell Physiol. doi:10.1002/jcp.21681 (2009) (Epub ahead of print).
10. Yu J, Vodyanik MA, Smuga-Otto K et al.: Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
11. Aasen T, Raya A, Barrero MJ et al.: Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol. 26, 1276-1284 (2008).
12. Aoi T, Yae K, Nakagawa M et al.: Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321, 699-702 (2008).
13. Nakagawa M, Koyanagi M, Tanabe K et al.: Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26, 101-106 (2008).
14. Huangfu D, Osafune K, Maehr R et al.: Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat. Biotechnol. 26, 1269-1275 (2008).
15. Eminli S, Utikal J, Arnold K et al.: Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells 26, 2467-2474 (2008).
16. Kim JB, Zaehres H, Wu G et al.: Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 454, 646-650 (2008).
17. Hanna J, Markoulaki S, Schorderet P et al.: Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 133, 250-264 (2008).
18. Feng B, Jiang J, Kraus P et al.: Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat. Cell Biol. 11, 197-203 (2009).
19. Stadtfeld M, Nagaya M, Utikal J et al.: Induced pluripotent stem cells generated without viral integration. Science 322, 945-949 (2008).
20. Okita K, Nakagawa M, Hyenjong H et al.: Generation of mouse induced pluripotent stem cells without viral vectors. Science 322, 949-953 (2008).
21. Kaji K, Norrby K, Paca A et al.: Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature doi:10.1038/nature07864 (2009) (Epub ahead of print).
22. Woltjen K, Michael IP, Mohseni P et al.: piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature doi:10.1038/nature07863 (2009) (Epub ahead of print).
23. Yu J, Hu K, Smuga-Otto K et al.: Human induced pluripotent stem cells free of vector and transgene sequences. Science doi:10.1126/ science.1172482 (2009) (Epub ahead of print).
24. Hanna J, Wernig M, Markoulaki S et al.: Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318, 1920-1923 (2007).
25. Wernig M, Zhao JP, Pruszak J et al.: Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl Acad. Sci. USA 105, 5856-5861 (2008).
26. Xu D, Alipio Z, Fink LM et al.: Phenotypic correction of murine hemophilia A using an iPS cell-based therapy. Proc. Natl Acad. Sci. USA 106, 808-813 (2009).
27. Nelson TJ, Behfar A, Terzic A: Strategies for therapeutic repair: the "R3" regenerative medicine paradigm. Clin. Transl. Sci. 1, 168-171 (2008).
28. Soldner F, Hockemeyer D, Beard C et al.: Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell doi:10.1016/j.cell.2009.02.013 (2009) (Epub ahead of print).
29. Nelson TJ, Behfar A, Terzic A: Stem cells: biologics for regeneration. Clin. Pharmacol. Ther. 84, 620-623 (2008).
30. Bartunek J, Sherman W, Vanderheyden M et al.: Delivery of biologics in cardiovascular regenerative medicine. Clin. Pharmacol. Ther. doi:10.1038/clpt.2008.295 (2009) (Epub ahead of print).