Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative activity

Biocatalysis and Biotransformation

Volumn 27, Issue 3, 2009, Pages 161-169

  Theodosiou, Eleni ^a   Katsoura, Maria M ^b   Loutrari, Heleni ^c   Purchartová, Kateřina ^d   Křen, Vladimír ^d   Kolisis, Fragiskos N ^a   Stamatis, Haralambos ^b  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF IOANNINA   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

Acylation; Antitumor proliferative activity; Ionic liquids; Lipase; Organic solvents; Silybin

Indexed keywords

ACYL DONORS; ALKYL CHAIN LENGTHS; ANTI-TUMORS; ANTIPROLIFERATIVE EFFECT; ANTITUMOR PROLIFERATIVE ACTIVITY; BIOCATALYTIC PREPARATION; BIOCATALYTIC PROCESS; CANDIDA ANTARCTICA LIPASE B; CONVERSION YIELD; ENZYMATIC PREPARATION; ENZYMATIC PROCESS; FREE FATTY ACID; HUMAN LEUKEMIA CELLS; IMIDAZOLIUM-BASED IONIC LIQUID; IONIC LIQUID MEDIA; MOLAR RATIO; PROLIFERATIVE ACTIVITY; REACTION MEDIA; SILYBIN;

ACETONE; ACYLATION; ESTERIFICATION; ESTERS; FATTY ACIDS; IONIZATION OF LIQUIDS; NEGATIVE IONS; ORGANIC SOLVENTS; REACTION RATES;

IONIC LIQUIDS;

ANTINEOPLASTIC AGENT; FLAVONOLIGNAN; IMIDAZOLE DERIVATIVE; IONIC LIQUID; LIPASE B; ORGANIC SOLVENT; SILIBININ; SILYBIN 23 O BUTANOATE; SILYBIN 23 O LAURATE; SILYBIN 23 O OLEATE; UNCLASSIFIED DRUG;

ACYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCATALYST; BIOTRANSFORMATION; CANDIDA ALBICANS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL;

CANDIDA ANTARCTICA;

EID: 68049137644     PISSN: 10242422     EISSN: 10292446     Source Type: Journal    
DOI: 10.1080/10242420902937777     Document Type: Article

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