Effects of silibinin and antioxidants on high glucose-induced alterations of fibronectin turnover in human mesangial cell cultures

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 3, 1996, Pages 1520-1526

  Wenzel, Simone ^a   Stolte, Hilmar ^b   Soose, Mechthild ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; FIBRONECTIN; FREE RADICAL; GLUCOSE; MANNITOL; OXYGEN RADICAL; SILIBININ;

ANTIOXIDANT ACTIVITY; ARTICLE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG EFFECT; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANTIOXIDANTS; CELL DIVISION; CELLS, CULTURED; EXTRACELLULAR SPACE; FIBRONECTINS; GLOMERULAR MESANGIUM; GLUCOSE; HUMANS; MALONDIALDEHYDE; SILYMARIN;

EID: 0030427016     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. ADLER, S.: Structure-function relationships associated with extracellular matrix alterations in diabetic glomerulopathy. J. Am. Soc. Nephrol. 5: 1165-1172, 1994.
2. ALTOMARE, E., VENDEMIALE, G., CHICCO, D., PROCACCI, V. AND CIRELLI, F.: Increased lipid peroxidation in type 2 poorly controlled diabetic patients. Diabetes Metab. Rev. 18: 264-271, 1992.
3. AYO, S. H., RADNIK, R. A., GLASS, W. F. II, GARONI, J. A., RAMPT, E. R., APPLING, D. R. AND KREISBERG, J. I.: Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium: Am. J. Physiol. 260: F185-F191, 1991.
4. BROCK, N., HILCARD, P., POHL, J., ORMSTAD, K. AND ORHENIUS, S.: Pharmacokinetics and mechanism of action of detoxifying low-molecular-weight thiols. J. Cancer Res. Clin. Oncol. 108: 87-97, 1984.
5. CARINI, R., COMOGLIO, A., ALBANO, E. AND POLI, G.: Lipid peroxidation and reversible damage in the rat hepatocytes model. Protection by the silybinphospholipid complex IdB 1016. Biochem. Pharmacol. 43: 2111-2115, 1992.
6. COLLIER, A., RUMLEY, A., RUMLEY, A. G., PATERSON, J. R., LEACH, J. P., LOWE, G. D. O. AND SMALL, M.: Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria. Diabetes 41: 909-913, 1992.
7. COSIO, F. G.: Effects of high glucose concentrations on human mesangial cell proliferation. J. Am. Soc. Nephrol. 5: 1600-1609, 1995.
8. CURCIO, F. AND CERIELLO, A.: Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: New insights on the pathophysiological mechanisms of diabetic vascular complications. In Vitro Cell. Dev. Biol. 28A: 787-790, 1992.
9. DANDONA, P., THUSU, K., COOK, S., SNYDER, B., MAKOWSKI, J., ARMSTRONG, D. AND NICOTERA, T.: Oxidative damage to DNA in diabetes mellitus. Lancet 347: 444-445, 1996.
10. DAVIES, M: The mesangial cell: A tissue culture view. Kidney Int. 45: 320-327, 1994.
11. DOROSHOW, J. H., AKMAN, S., CHU, F.-F. AND ESWORTHY, S.: Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones. Pharmacol. Ther. 47: 359-370, 1990.
12. FREEMAN, B. A. AND CRAPO, J. D.: Biology of disease. Free radicals and tissue injury. Lab. Invest. 47: 412-426, 1982.
13. GAEDEKE, J., FELS, L. M., BOKEMEYER, C., MENGS, U., STOLTE, H. AND LENTZEN, H.: Cisplatin nephrotoxicity and protection by silibinin. Nephrol. Dial. Transplant. 11: 55-62, 1996.
14. HAGEMANN, J. J., BAST, A. AND VERMEULEN, N. P. E.: Monitoring of oxidative free radical damage in vivo; Analytical aspects. Chem.-Biol. Inter. 82: 243-293, 1992.
15. HYNES, R. O.: Fibronectins, ed. by A. Rich, Springer-Verlag, New York, 1989.
16. KEIZER, H. G., PINEDO, H. M., SCHUURHUIS, G. J. AND JOENJE, H.: Doxorubicin (adriamycin): A critical review of free-radical dependent mechanisms of cytotoxicity. Pharmacol. Ther. 47: 219-231, 1990.
17. KREISBERG, J. I. AND AYO, S. H.: The glomerular mesangium in diabetes mellitus. Kidney Int. 43: 109-113, 1993.
18. LENG-PESCHLOW, E. AND STRENGE-HESSE, A.: Die Mariendistel (Silybum marianum) und Silymarin als Lebertherapeutikum. Z. Phytother. 12: 162-174, 1991.
19. LETTÉRON, P., LABBE, G., DEGOTT, C., BERSON, A., FROMENTY, B., DELAFORGE, M., LARREY, D. AND PESSAYRE, D.: Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant. Biochem. Pharmacol. 39: 2027-2034, 1990.
20. LI, L., WATTIAUX-DE CONINCK, S. AND WATTIAUX, R.: Endocytosis of superoxide dismutase by rat liver. Biochem. Biophys. Res. Commun. 184: 727-732, 1992.
21. LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. AND RANDALL, R. J.: Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
22. MCLENNAN, S. V., FISHER, E. J., YUE, D. K. AND TURTLE, J. R: High glucose concentration causes a decrease in mesangium degradation. Diabetes 43: 1041-1045, 1994.
23. MENÉ, P., CINOTTI, G. A. AND PUGLIESE, F.: Mesangial cells in diabetes. Acta Diabetol. 29: 227-230, 1992.
24. MURIEL, P., GARCIAPIÑA, T., PEREZ-ALVAREZ, V. AND MOURELLE, M.: Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J. Appl. Toxicol. 12: 439-442, 1992.
25. NAHMAN, N. S., LEONHART, K. L., COSIO, F. G. AND HEBERT, C. L.: Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells. Kidney Int. 41: 396-402, 1992.
26. OBERLEY, L. W.: Free radicals and diabetes. Free Rad. Biol. Med. 5: 113-124, 1988.
27. OHKAWA, H., OHISHI, N. AND YAGI, K.: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358, 1979.
28. RADEKE, H. H., MEIER, B., TOPLEY, N., FLOEGE, J., HABERMEHL, G. G. AND RESCH, K.: Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells. Kidney Int. 37: 767-775, 1990.
29. ROTH, T., PODESTA, F., STEPP, M. A., BOERI, D. AND LORENZI, M.: Integrin overexpression induced by high glucose and by human diabetes: Potential pathway to cell dysfunction in diabetic microangiopathy. Proc. Natl. Acad. Sci. U.S.A. 90: 9640-9644, 1993.
30. ROY, S., CAGLIERO, E. AND LORENZI, M.: Fibronectin overexpression in retinal microvessels of patients with diabetes. Invest. Ophthalmol. Visual Sci. 37: 258-266, 1996.
31. SCHULZ, H.-U., SCHÜRER, M., KRUMBIEGEL, G., WÄCHTER, W., WEYHENMEYER, R. AND SEIDEL, G.: Untersuchungen zum Freisetzungsverhalten und zur Bioäquivalenz von Silymarin-Präparaten. Arzneim.-Forsch. 46: 61-64, 1995.
32. SONNENBICHLER, J. AND ZETL, I.: Stimulating influence of a flavonolignane derivate on proliferation, RNA synthesis and protein synthesis in liver cells. In Assessment and Management of Hepatobiliary Disease, ed. by L. Okolicsányi, G. Csomós and G. Crepakdi, pp. 265-272, Springer-Verlag, Berlin, 1987.
33. SOOSE, M.: Properties of silibinin and of antioxidants against adriamycin cytotoxicity in an unicellular eukaryote, Tetrahymena thermophila. Eur. J. Protistol. 30: 394-403, 1994.
34. SOOSE, M., GWINNER, W., GROTKAMP, J., HANSEMANN, W. AND STOLTE, H.: Altered renal fibronectin excretion in early adriamycin nephrosis of rats. J. Pharmacol. Exp. Ther. 257: 493-499, 1991.
35. SOOSE, M., WENZEL, S., PADUR, A., OBERST, D. AND STOLTE, H.: Fibronectin expression in human mesangial cell cultures and its alterations by adriamycin. Cell. Biol. Toxicol. 11: 51-63, 1995.
36. SOOSE, M., WENZEL, S. AND STOLTE, H.: Fibronectin turnover in human mesangial cell cultures as affected by adriamycin. Cell Biol. Toxicol. 9: 149-164, 1993.
37. SOOSE, M., ZULAUF, J., BAUER, M. AND STOLTE, H.: A comparative study on the response of two established cell lines to adriamycin. Growth and biomass production in human mesangial cell cultures and in Tetrahymena thermophila. Eur. J. Protistol. 30: 75-84, 1994.
38. TESCHNER, M., SCHAEFER, R. M., BAHNER, U. AND HEIDLAND, A.: Nephropathie bei Typ-I-Diabetes. Dtsch. Med. Wochenschr. 117: 1730-1734, 1992a.
39. TESCHNER, M., SCHAEFER, R. M., PACZEK, L. AND HEIDLAND, A.: Effect of renal disease on glomerular proteinases. Miner. Electrolyte Metab. 18: 92-96, 1992b.
40. TRACHTMAN, H., FUTTERWEIT, S., PRENNER, J. AND HANON, S.: Antioxidants reverse the antiproliferative effect of high glucose and advanced glycosylation end products in cultured rat mesangial cells. Biochem. Biophys. Res. Commun. 199: 346-352, 1994.
41. VALENZUELA, A., LAGOS, C., SCHMIDT, K. AND VIDELA, L. A.: Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. Biochem. Pharmacol. 34: 2209-2212, 1985.
42. VELUSSI, M., CERNOGOI, A. M., VIEZZOLI, L., DAPAS, F., CAFFAU, C. AND ZILLI, M.: Silymarin reduces hyperinsulinemia, malondialdehyde levels, and daily insulin need in cirrhotic diabetic patients. Curr. Ther. Res. 53: 533-545, 1993.
43. WEYHENMEYER, R., MASCHER, H. AND BIRKMAYER, J.: Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay. Int. J. Clin. Pharmacol. Ther. Toxicol. 30: 134-138, 1992.
44. WOLFF, S. P.: Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br. Med. Bull. 49: 642-652, 1993.