Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits

Arthritis and Rheumatism

Volumn 60, Issue 8, 2009, Pages 2372-2380

  Takahashi, Daisuke ^a   Iwasaki, Norimasa ^a   Kon, Shigeyuki ^b   Matsui, Yuichiro ^a   Majima, Tokifumi ^a   Minami, Akio ^a   Uede, Toshimitsu ^b  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GENETIC MANIPULATION; GENETIC TRANSDUCTION; HISTOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; SYNOVIUM;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; OSTEOARTHRITIS; RABBITS; RNA, MESSENGER; RNA, SMALL INTERFERING; SYNOVIAL MEMBRANE; TRANSDUCTION, GENETIC;

EID: 68049115664     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24718     Document Type: Article

References (39)

1. Cicuttini FM, Spector TD. Genetics of osteoarthritis. Ann Rheum Dis 1996;55:665-7.
2. Neyret P, Donell ST, DeJour D, DeJour H. Partial meniscectomy and anterior cruciate ligament rupture in soccer players: a study with a minimum 20-year followup. Am J Sports Med 1993;21:455-60.
3. Sharma L, Lou C, Felson DT, Dunlop DD, Kirwan-Mellis G, Hayes KW, et al. Laxity in healthy and osteoarthritic knees. Arthritis Rheum 1999;42:861-70.
4. Borden P, Solymar D, Sucharczuk A, Lindman B, Cannon P, Heller RA. Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes [published erratum appears in J Biol Chem 1996;271:33706]. J Biol Chem 1996;271:23577-81.
5. Goldring MB. The role of the chondrocyte in osteoarthritis [review]. Arthritis Rheum 2000;43:1916-26.
6. Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ, Galdo F. Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology. Arthritis Rheum 1998;41:284-9.
7. D'Lima DD, Hashimoto S, Chen PC, Lotz MK, Colwell CW Jr. Prevention of chondrocyte apoptosis. J Bone Joint Surg Am 2001;83-A Suppl 2(Pt 1):25-6.
8. Kim HA, Lee YJ, Seong SC, Choe KW, Song YW. Apoptotic chondrocyte death in human osteoarthritis. J Rheumatol 2000;27:455-62.
9. Kim HA, Suh DI, Song YW. Relationship between chondrocyte apoptosis and matrix depletion in human articular cartilage. J Rheumatol 2001;28:2038-45.
10. Yuan GH, Masuko-Hongo K, Kato T, Nishioka K. Immunologic intervention in the pathogenesis of osteoarthritis [review]. Arthritis Rheum 2003;48:602-11.
11. Miossec P. Are T cells in rheumatoid synovium aggressors or bystanders? Curr Opin Rheumatol 2000;12:181-5.
12. Haraoui B, Pelletier JP, Cloutier JM, Faure MP, Martel-Pelletier J. Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis: in vivo effects of antirheumatic drugs. Arthritis Rheum 1991;34:153-63.
13. Kennedy TD, Plater-Zyberk C, Partridge TA, Woodrow DF, Maini RN. Morphometric comparison of synovium from patients with osteoarthritis and rheumatoid arthritis. J Clin Pathol 1988; 41:847-52.
14. Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets [review]. Arthritis Rheum 2001;44:1237-47.
15. Tiraloche G, Girard C, Chouinard L, Sampalis J, Moquin L, Ionescu M, et al. Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum 2005;52:1118-28.
16. Carlson CS, Loeser RF, Purser CB, Gardin JF, Jerome CP. Osteoarthritis in cynomolgus macaques. III. Effects of age, gender, and subchondral bone thickness on the severity of disease. J Bone Miner Res 1996;11:1209-17.
17. Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971;53:523-37.
18. Kon S, Yokosaki Y, Maeda M, Segawa T, Horikoshi Y, Tsukagoshi H, et al. Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. J Cell Biochem 2002;84:420-32.
19. Ohashi S, Kubo T, Kishida T, Ikeda T, Takahashi K, Arai Y, et al. Successful genetic transduction in vivo into synovium by means of electroporation. Biochem Biophys Res Commun 2002;293:1530-5.
20. Jennings K, Miyamae T, Traister R, Marinov A, Katakura S, Sowders D, et al. Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo. Mol Ther 2005;11:600-7.
21. McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. RNA interference in adult mice. Nature 2002;418:38-9.
22. Lewis DL, Hagstrom JE, Loomis AG, Wolff JA, Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 2002;32:107-8.
23. Schiffelers RM, Xu J, Storm G, Woodle MC, Scaria PV. Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. Arthritis Rheum 2005;52:1314-8.
24. Kiviranta R, Morko J, Uusitalo H, Aro HT, Vuorio E, Rantakokko J. Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin K. J Bone Miner Res 2001;16:1444-52.
25. Morko J, Kiviranta R, Hurme S, Rantakokko J, Vuorio E. Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K. Bone 2005;36:854-65.
26. Dodds RA, Connor JR, Drake FH, Gowen M. Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues. Arthritis Rheum 1999;42:1588-93.
27. Punturieri A, Filippov S, Allen E, Caras I, Murray R, Reddy V, et al. Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J Exp Med 2000;192:789-99.
28. Buhling F, Gerber A, Hackel C, Kruger S, Kohnlein T, Bromme D, et al. Expression of cathepsin K in lung epithelial cells. Am J Respir Cell Mol Biol 1999;20:612-9.
29. Haeckel C, Krueger S, Buehling F, Broemme D, Franke K, Schuetze A, et al. Expression of cathepsin K in the human embryo and fetus. Dev Dyn 1999;216:89-95.
30. Haeckel C, Krueger S, Kuester D, Ostertag H, Samii M, Buehling F, et al. Expression of cathepsin K in chordoma. Hum Pathol 2000;31:834-40.
31. Tepel C, Bromme D, Herzog V, Brix K. Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. J Cell Sci 2000;113(Pt 24):4487-98.
32. Konttinen YT, Mandelin J, Li TF, Salo J, Lassus J, Liljestrom M, et al. Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. Arthritis Rheum 2002;46:953-60.
33. Morko JP, Soderstrom M, Saamanen AM, Salminen HJ, Vuorio EI. Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis. Ann Rheum Dis 2004;63:649-55.
34. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, et al. Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis. Science 2008;319:624-7.
35. Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996;97:761-8.
36. Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes: a role in osteoarthritis. J Clin Invest 1996;97:2011-9.
37. Hou WS, Li Z, Gordon RE, Chan K, Klein MJ, Levy R, et al. Cathepsin K is a critical protease in synovial fibroblast-mediated collagen degradation. Am J Pathol 2001:159:2167-77.
38. Everts V, Hou WS, Rialland X, Tigchelaar W, Saftig P, Bromme D, et al. Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts. Calcif Tissue Int 2003:73:380-6.
39. Levine B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 2005:120:159-62.