Suppression of sulfur mustard-increased IL-8 in human keratinocyte cell cultures by serine protease inhibitors: Implications for toxicity and medical countermeasures

Cell Biology and Toxicology

Volumn 18, Issue 3, 2002, Pages 175-180

  Cowan, Fred M ^a   Broomfield, C A ^a   Smith, W J ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

IL 8; Protease; Protease inhibitor; Sulfur mustard; Toxicity

Indexed keywords

4 GUANIDINOBENZOIC ACID ETHYL ESTER; ANTIDOTE; CYTOKINE; INTERLEUKIN 8; MUSTARD GAS; SERINE PROTEINASE INHIBITOR; TOSYLLYSYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG; CHEMICAL WARFARE AGENT;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL WARFARE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; TOXICITY TESTING; ANIMAL TESTING ALTERNATIVE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

ANIMAL TESTING ALTERNATIVES; CELLS, CULTURED; CHEMICAL WARFARE AGENTS; HUMAN; INTERLEUKIN-8; KERATINOCYTES; MUSTARD GAS; SERINE PROTEINASE INHIBITORS; TOSYLLYSINE CHLOROMETHYL KETONE; HUMANS;

ANIMALIA; RODENTIA;

EID: 0035986173     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015511720481     Document Type: Article

References (20)

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2. Response of normal human keratinocytes to sulfur mustard (HD): Cytokine release using a non-enzymatic detachment procedure
3. Effect of topically applied drugs against HD-induced cutaneous injury in the mouse car edema model
4. In vivo therapeutic prophylactic protection against cutaneous sulfur mustard injury using the mouse ear vesicant model (MEVM)
5. Biochemiccal alterations in rat lung lavage fluid following acute sulfur mustard inhalation. II. Increases in proteolytic activity
6. Putative roles of inflammation in the dermatopathology of sulfur mustard
7. Sulfur mustard exposure enhances Fc receptor expression on human epidermal keratinocytes in cell culture: Implications for toxicity and medical countermeasures
8. Putative role of proteases and other inflammatory-neuronal molecules in the toxicity of nerve and blister chemical warfare agents
9. Protease released in organ culture by acute inflammatory lesions produced in rabbit skin by sulfur mustard: Hydrolysis of synthetic peptide substrates for trypsin-like and chymotrypsin-like enzymes
10. Aprotinin reduces interleukin-8 production and lung neutrophil accumulation after cardiopulmonary bypass
11. Sulfur mustard up regulates the expression of interleukin-8 in cultured human keratinocytes
12. Cutaneous exposure to bis-(2-chloroethyl) sulfide results in neutrophil infiltration and increased solubility of 180,000 Mr subepithelial collagens
13. Molecular basis for mustard-induced vesication
14. Inflammatory gene expression in mouse skin following sulfur mustard exposure
15. Development of medical countermeasures to sulfur mustard vesication
16. Human epidermal keratinocytes exposed in vitro to the vesicating agent sulfur mustard express markers of apoptosis and inflammation
17. Normal human epidermal keratinocyte-derived neutrophil chemotactic factor
18. Identification and pharmacological characterization of platelet activating factor and related 1-palmitoyl species in human inflammatory blistering diseases
19. The cytokines NAP-1 (IL-8), MCP-1, IL-1 beta, and GRO in rabbit inflammatory skin lesions produced by the chemical irritant sulfur mustard