Searching for disease modifiers - PKC activation and HDAC inhibition - A dual drug approach to Alzheimer's disease that decreases Aβ production while blocking oxidative stress

ChemMedChem

Volumn 4, Issue 7, 2009, Pages 1095-1105

  Kozikowski, Alan P ^a   Chen, Yihua ^a   Subhasish, Tapadar ^a   Lewin, Nancy E ^b   Blumberg, Peter M ^b   Zhong, Zhenyu ^c   D'Annibale, Melissa A ^d   Wang, Weng Long ^a   Shen, Yong ^c   Langley, Brett ^d,e  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SUN HEALTH RESEARCH INSTITUTE   (United States)

^d BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Alzheimer's disease; Amyloid ; HDAC inhibition; Neuroprotection; PKC activation

Indexed keywords

1,2,3,4,5,6 HEXAHYDRO 5 (HYDROXYMETHYL) 2 ISOPROPYL 1METHYL 3 OXOBENZO[E][1,4]DIAZOCIN 9 YL 5 (1,2-DITHIOLAN 3 YL)PENTANOATE; 1N [2 (5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 3 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[E][1,4]DIAZOCIN 9 YLOXY)ETHYL] 5 (1,2 DITHIOLAN 3 YL)PENTANAMIDE; 9 HEPT 6 ENYLOXY 5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 1,4,5,6 TETRAHYDRO 2H BENZO[E][1,4]DIAZOCIN 3 ONE; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; HISTONE DEACETYLASE; HISTONE H4; HOMOCYSTEIC ACID; LACTAM DERIVATIVE; PROTEIN KINASE C; THIOACETIC ACID [3 (5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 3 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[E][1,4]DIAZOCIN 9 YLOXY)PROPYL]ESTER; THIOACETIC ACID [4 (5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 3 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[E][1,4]DIAZOCIN 9 YLOXY)BUTYL]ESTER; THIOACETIC ACID [5 (5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 3 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[E][1,4]DIAZOCIN 9 YLOXY)PENTYL]ESTER; THIOACETIC ACID [6 (5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 3 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[E][1,4]DIAZOCIN 9 YLOXY)HEXYL]ESTER; THIOACETIC ACID [7 (5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 3 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[E][1,4]DIAZOCIN 9 YLOXY)HEPTYL]ESTER; THIOACETIC ACID [8 (5 HYDROXYMETHYL 2 ISOPROPYL 1 METHYL 3 OXO 1,2,3,4,5,6 HEXAHYDROBENZO[E][1,4]DIAZOCIN 9 YLOXY)OCTYL]ESTER; UNCLASSIFIED DRUG;

ACETYLATION; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; COMPUTER SIMULATION; HISTONE DEACETYLASES; HUMANS; LACTAMS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 67749147448     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900045     Document Type: Article

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