Antenatal betamethasone does not influence lymphocyte apoptosis in preterm neonates

American Journal of Perinatology

Volumn 26, Issue 7, 2009, Pages 485-490

  Agakidis, Charalampos ^a,b   Sarafidis, Kosmas ^a   Tzimouli, Vasiliki ^a   Agakidou, Eleni ^a   Taparkou, Anna ^a   Kanakoudi Tsakalidou, Florence ^a   Soubasi Griva, Vasiliki ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b NONE   (Greece)

Author keywords

Annexin V; Caspase 3; Leukocytes; Propidium iodine

Indexed keywords

BETAMETHASONE; CASPASE 3; LIPOCORTIN 5; PROPIDIUM IODIDE; SURFACTANT;

APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; CELL ACTIVITY; CELL CYCLE; CELL CYCLE G1 PHASE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; LYMPHOCYTE COUNT; MALE; NEWBORN; PREMATURITY; PRENATAL PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY DISTRESS SYNDROME;

APGAR SCORE; APOPTOSIS; BETAMETHASONE; BIRTH WEIGHT; CASPASE 3; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; PREGNANCY; PRENATAL CARE; PROBABILITY; PROSPECTIVE STUDIES; SEX FACTORS; STATISTICS, NONPARAMETRIC;

EID: 67749104789     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0029-1214249     Document Type: Article

References (37)

1. Roberts D, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006;3:CD004454 (Pubitemid 46796994)
2. Reznikov A, Nosenko N, Tarasenko L, Sinitsyn P, Polyakova L, Mishunina T. Neuroendocrine disorders in adult rats treated prenatally with hydrocortisone acetate. Exp Toxicol Pathol 2008;60:489-497
3. Sloboda DM, Moss TJ, Li S, Matthews SG, Challis JR, Newnham P. Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxusteroid dehydrogenase 1 and 2 in the fetal and postnatal ovin hippocampus: ontogeny and effects of prenatal glucocorticoid exposure. J Endocrinol 2008;197:213-220 (Pubitemid 351696234)
4. Kavelaars A, Cats B, Visser GHA, et al. Ontogeny of the response of human peripheral blood T cells to glucocorticoids. Brain Behav Immun 1996;10:288-297 (Pubitemid 27007855)
5. Tuckermann JP, Kleiman A, McPherson KG, Reichardt HM. Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis. Crit Rev Clin Lab Sci 2005;42:71-104 (Pubitemid 41656710)
6. Zhang N, Hatrig H, Dzhagalov I, Draper D, He YW. The role of apoptosis in the development and function of T lymphocytes. Cell Res 2005;15:749-769 (Pubitemid 41653913)
7. Di Sabatino A, D'Alo S, Millimaggi D, et al. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease. Immunology 2001;103:435-440 (Pubitemid 32744389)
8. Diaz D, Prieto A, Barcenilla H, et al. Loss of lineage antigens is a common feature of apoptotic lymphocytes. J Leukoc Biol 2004;76:609-615 (Pubitemid 39129093)
9. Schroeder S, Lindemann C, Decker D, et al. Increased susceptibility to apoptosis in circulating lymphocytes of critically ill patients. Langenbecks Arch Surg 2001;386:42-46 (Pubitemid 32186967)
10. Hotchkiss RS, Coopersmith CM, Kari IE. Prevention of lymphocyte apoptosis-a potential treatment of sepsis? Clin Infect Dis 2005;41:S465-S469
11. Felmet KA, Mark WH, Clark RSB, Jaffe R, Carcillo JA. Prolonged lymphopenia, lymphoid depletion, and lypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol 2005;174:3765-3772 (Pubitemid 40354089)
12. Tian C, Kron GK, Dischert KM, Higginbotham JN, Crowe JE Jr. Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signaling via the IL-4 receptor complex in human neonatal B cell. Immunology 2006;119:54-62 (Pubitemid 44201155)
13. Marshall-Clarke S, Reen D, Tasker L, Hassan J. Neonatal immunity: how well has it grown up? Immunol Today 2000;21:35-41
14. Bakker JM, Schmidt ED, Kroes H, et al. Effects of neonatal dexamethasone treatment on hypothalamo-pituitary adrenal axis and immune system of the rat. J Neuroimmunol 1997;74:69-76 (Pubitemid 27128979)
15. Chabra S, Cottrill C, Rayens MK, Cross K, Lipke D, Bruce M. Lymphocyte subsets in cord blood of preterm infants: effect of antenatal steroids. Biol Neonate 1998;74:200-207 (Pubitemid 28391292)
16. Kavelaars A, van der Pompe G, Bakker JM, et al. Altered immune function in human newborns after prenatal administration of betamethasone: enhanced natural killer cell activity and decreased T cell proliferation in cord blood. Pediatr Res 1999;45:306-312 (Pubitemid 29157759)
17. Saha NR, Usami T, Suzuki Y. A double staining flow cytometric assay for the detection of steroid induced apoptotic leucocytes in common carp (Cyprinus carpio). Dev Comp Immunol 2003;27:351-363 (Pubitemid 36288448)
18. Weyts FA, Flik G, Rombout JH, Verbung-van Kemenade BM. Cortisol induces apoptosis in activated B cells, not in other lymphoid cells of the common carp. Dev Comp Immunol 1998;22:551-562 (Pubitemid 28541173)
19. Walsh CJ, Wyffels JT, Bodine AB, Luer CA. Dexamethasone-induced apoptosis in immune cells from peripheral circulation and lymphomyeloid tissues of juvenile clearnose skates, Raja eglanteria. Dev Comp Immunol 2002;26:623-633
20. Bianchini R, Nocentini G, Krausz LT, et al. Modulation of pro- and anti- apoptotic molecules in double positive (CD4+CD8+) thymocytes following dexamethasone treatment. J Pharmacol Exp Ther 2006;319:887-897 (Pubitemid 44776395)
21. Kirsch AH, Mahmood AA, Endres J, et al. Apoptosis of human T-cells: induction by glucocorticoids or surface receptor ligation in vitro and ex vivo. J Biol Regul Homeost Agents 1999;13:80-89 (Pubitemid 30742073)
22. Lanza L, Scudeletti M, Puppo F, et al. Prednisone increases apoptosis in vitro activated human peripheral blood T lymphocytes. Clin Exp Immunol 1996;103:482-490 (Pubitemid 26089952)
23. Marchetti MC, Di Marco B, Cifone G, Migliorati G, Riccardi C. Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation. Blood 2003;101:585-593 (Pubitemid 36077581)
24. Gold R, Buttgereit F, Toyka KV. Mechanism of action of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders. J Neuroimmunol 2001;117:1-8 (Pubitemid 32595488)
25. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 1997;27:1-20 (Pubitemid 27059777)
26. Darzynkiewicz Z, Huang X, Okafuji M. Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication). Methods Mol Biol 2006;314:81-93
27. Schwarze J, Bartmann P. Influence of dexamethasone on lymphocyte proliferation in whole blood cultures of neonates. Biol Neonate 1994;65:295-301 (Pubitemid 24134133)
28. Kramer BW, Ikegami M, Moss TJ, Nitsos I, Newman JP, Jobe AH. Antenatal betamethasone changes cord blood monocyte responses to endotoxin in preterm neonates. Pediatr Res 2004;55:764-768 (Pubitemid 38520441)
29. Peng CT, Lin HC, Lin YJ, Tsai CH, Yeh TF. Early dexamethasone therapy and blood cell count in preterm infants. Pediatrics 1999;104:476-481
30. Fritzsching B, Oberle N, Pauly E, et al. Naïve regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 2006;108:3371-3378 (Pubitemid 44776876)
31. El-Ghalbzouri A, Drenou B, Blancheteau V, et al. An in vitro model of allogeneic stimulation of cord blood induction of Fas independent apoptosis. Hum Immunol 1999;60:598-607 (Pubitemid 29328615)
32. Potestio M, Pawelec G, Di Lorenzo G, et al. Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes. Exp Gerontol 1999;34:659-673 (Pubitemid 29420329)
33. Belvisi MG, Wicks SL, Battram CH, et al. Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity. J Immunol 2001;166:1975-1982
34. Sternberg EM. Neuroendocrine regulation of autoimmune/inflammatory disease. J Endocrinol 2001;169:429-435
35. Webster JI, Tonelli L, Sternberg EM. Neuroendocrine regulation of immunity. Annu Rev Immunol 2002;20:125-163
36. De Bosscher K, Vanden Berghe W, Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-B or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 2003;24:488-522 (Pubitemid 37059110)
37. Ballard PL, Ballard RA. Scientific basis and therapeutic regimens for use of antenatal glucocorticoids (review). Am J Obstet Gynecol 1995;173:254-262