Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells

Immunology

Volumn 119, Issue 1, 2006, Pages 54-62

  Tian, Cuixia ^a   Kron, Grace K ^a   Dischert, Kevin M ^a   Higginbotham, James N ^a   Crowe Jr , James E ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

B cells; Chemokines; Human studies; Interleukins; Neonatal

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; RECEPTOR SUBTYPE;

ANTIBODY RESPONSE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL MATURATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE SUBPOPULATION; NEWBORN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ADULT; ANALYSIS OF VARIANCE; APOPTOSIS; B-LYMPHOCYTES; CELL SEPARATION; FETAL BLOOD; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; INFANT, NEWBORN; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; INTERLEUKIN-4; INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR;

EID: 33746864480     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02405.x     Document Type: Article

References (49)

1. Marshall-Clarke S, Reen D, Tasker L, Hassan J. Neonatal immunity: how well has it grown up? Immunol Today 2000; 21:35-41.
2. Lawton AR. Ontogeny of B cells and pathogenesis of humoral immunodeficiencies. Clin Immunol Immunopathol 1986; 40:5-12.
3. Andersson U, Bird G, Britton S. A sequential study of human B lymphocyte function from birth to two years of age. Acta Paediatr Scand 1981; 70:837-42.
4. Siegrist CA. Neonatal and early life vaccinology. Vaccine 2001; 19:3331-46.
5. Andersson U, Bird G, Britton S. Cellular mechanisms of restricted immunoglobulin formation in the human neonate. Eur J Immunol 1980; 10:888-94.
6. Garcia AM, Fadel SA, Cao S, Sarzotti M. T cell immunity in neonates. Immunol Res 2000; 22:177-90.
7. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004; 4:553-64.
8. Lu CY, Calamai EG, Unanue ER. A defect in the antigen-presenting function of macrophages from neonatal mice. Nature 1979; 282:327-9.
9. King LB, Norvell A, Monroe JG. Antigen receptor-induced signal transduction imbalances associated with the negative selection of immature B cells. J Immunol 1999; 162:2655-62.
10. Marshall-Clarke S, Tasker L, Parkhouse RM. Immature B lymphocytes from adult bone marrow exhibit a selective defect in induced hyperexpression of major histocompatibility complex class II and fail to show B7.2 induction. Immunology 2000; 100:141-51.
11. Benschop RJ, Brandl E, Chan AC, Cambier JC. Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation. J Immunol 2001; 167:4172-9.
12. Tasker L, Marshall-Clarke S. Functional responses of human neonatal B lymphocytes to antigen receptor cross-linking and CpG DNA. Clin Exp Immunol 2003; 134:409-19.
13. Klein U, Rajewsky K, Kuppers R. Human immunoglobulin (Ig) M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998; 188:1679-89.
14. Galibert L, Burdin N, Barthelemy C et al. Negative selection of human germinal center B cells by prolonged BCR cross-linking. J Exp Med 1996; 183:2075-85.
15. Galibert L, Burdin N, de Saint-Vis B et al. CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J Exp Med 1996; 183:77-85.
16. Hodgkin PD, Go NF, Cupp JE, Howard M. Interleukin-4 enhances anti-IgM stimulation of B cells by improving cell viability and by increasing the sensitivity of B cells to the anti-IgM signal. Cell Immunol 1991; 134:14-30.
17. Illera VA, Perandones CE, Stunz LL, Mower DA Jr, Ashman RF. Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4. J Immunol 1993; 151:2965-73.
18. Parry SL, Hasbold J, Holman M, Klaus GG. Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40. J Immunol 1994; 152:2821-9.
19. Wagner EF, Hanna N, Fast LD et al. Novel diversity in IL-4-mediated responses in resting human naive B cells versus germinal center/memory B cells. J Immunol 2000; 165:5573-9.
20. Tangye SG, Avery DT, Deenick EK, Hodgkin PD. Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J Immunol 2003; 170:686-94.
21. Fecteau JF, Neron S. CD40 stimulation of human peripheral B lymphocytes: distinct response from naive and memory cells. J Immunol 2003; 171:4621-9.
22. Wurster AL, Withers DJ, Uchida T, White MF, Grusby MJ. Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol 2002; 22:117-26.
23. Zamorano J, Wang HY, Wang LM, Pierce JH, Keegan AD. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. J Immunol 1996; 157:4926-34.
24. Clark EA, Shu GL, Luscher B et al. Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals. J Immunol 1989; 143:3873-80.
25. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996; 4:313-9.
26. Wurster AL, Rodgers VL, White MF, Rothstein TL, Grusby MJ. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem 2002; 277:27169-75.
27. Lomo J, Blomhoff HK, Jacobsen SE, Krajewski S, Reed JC, Smeland EB. Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1. Blood 1997; 89:4415-24.
28. McKenzie AN, Zurawski G. Interleukin-13: characterization and biologic properties. Cancer Treat Res 1995; 80:367-78.
29. Lai YH, Mosmann TR. Mouse IL-13 enhances antibody production in vivo and acts directly on B cells in vitro to increase survival and hence antibody production. J Immunol 1999; 162:78-87.
30. Zurawski SM, Chomarat P, Djossou O et al. The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J Biol Chem 1995; 270:13869-78.
31. de Waal Malefyt R, Abrams JS, Zurawski SM et al. Differential regulation of IL-13 and IL-4 production by human CD8+ and CD4+ Th0, Th1 and Th2 T cell clones and EBV-transformed B cells. Int Immunol 1995; 7:1405-16.
32. Demaziere A, Leek R, Athanasou NA. Histological distribution of the interleukin-4 receptor (IL4R) within the normal and pathological synovium. Rev Rhum Mal Osteoartic 1992; 59:219-24.
33. Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 1999; 17:701-38.
34. Graber P, Gretener D, Herren S et al. The distribution of IL-13 receptor alpha1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4. Eur J Immunol 1998; 28:4286-98.
35. Izuhara K, Yang G, Miyajima A, Howard M, Harada N. Structure of the IL4 receptor and signal transduction mechanism of IL4. Res Immunol 1993; 144:584-90.
36. -ΔΔCT method. Methods 2001; 25:402-8.
37. Agematsu K, Hokibara S, Nagumo H, Komiyama A. CD27: a memory B-cell marker. Immunol Today 2000; 21:204-6.
38. Shi Y, Agematsu K, Ochs HD, Sugane K. Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM. Clin Immunol 2003; 108:128-37.
39. Defrance T, Vanbervliet B, Aubry JP et al. B cell growth-promoting activity of recombinant human interleukin 4. J Immunol 1987; 139:1135-41.
40. Vitetta ES, Ohara J, Myers CD, Layton JE, Krammer PH, Paul WE. Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med 1985; 162:1726-31.
41. Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE. Identification and characterization of circulating human transitional B cells. Blood 2005; 105:4390-8.
42. Ohara J, Paul WE. Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression. Proc Natl Acad Sci USA 1988; 85:8221-5.
43. Renz H, Domenico J, Gelfand EW. IL-4-dependent up-regulation of IL-4 receptor expression in murine T and B cells. J Immunol 1991; 146:3049-55.
44. Siepmann K, Wohlleben G, Gray D. CD40-mediated regulation of interleukin-4 signaling pathways in B lymphocytes. Eur J Immunol 1996; 26:1544-52.
45. Jullien P, Cron RQ, Dabbagh K et al. Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation. Int Immunol 2003; 15:1461-72.
46. Brugnoni D, Airo P, Graf D et al. Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn. Eur J Immunol 1994; 24:1919-24.
47. Nonoyama S, Penix LA, Edwards CP et al. Diminished expression of CD40 ligand by activated neonatal T cells. J Clin Invest 1995; 95:66-75.
48. Elliott SR, Roberton DM, Zola H, Macardle PJ. Expression of the costimulator molecules, CD40 and CD154, on lymphocytes from neonates and young children. Hum Immunol 2000; 61:378-88.
49. Han P, McDonald T, Hodge G. Potential immaturity of the T-cell and antigen-presenting cell interaction in cord blood with particular emphasis on the CD40-CD40 ligand costimulatory pathway. Immunology 2004; 113:26-34.