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Volumn 89, Issue 3, 2009, Pages 358-364

Human iris pigment epithelial cells suppress T-cell activation via direct cell contact

Author keywords

co stimulatory molecule; immune privilege; iris pigment epithelial cell; PD 1; PD L1; PD L2

Indexed keywords

CD3 ANTIBODY; GAMMA INTERFERON; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROGRAMMED DEATH LIGAND 1; PROGRAMMED DEATH LIGAND 2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 67651229244     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.04.004     Document Type: Article
Times cited : (8)

References (46)
  • 3
    • 0035173022 scopus 로고    scopus 로고
    • Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1
    • D'Orazio T.J., Mayhew E., and Niederkorn J.Y. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1. J. Immunol. 166 (2001) 26-32
    • (2001) J. Immunol. , vol.166 , pp. 26-32
    • D'Orazio, T.J.1    Mayhew, E.2    Niederkorn, J.Y.3
  • 4
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H., Zhu G., Tamada K., and Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5 (1999) 1365-1369
    • (1999) Nat. Med. , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 8
    • 0037152153 scopus 로고    scopus 로고
    • Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
    • Ishida M., Iwai Y., Tanaka Y., Okazaki T., Freeman G.J., Minato N., and Honjo T. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol. Lett. 84 (2002) 57-62
    • (2002) Immunol. Lett. , vol.84 , pp. 57-62
    • Ishida, M.1    Iwai, Y.2    Tanaka, Y.3    Okazaki, T.4    Freeman, G.J.5    Minato, N.6    Honjo, T.7
  • 9
    • 0037815272 scopus 로고    scopus 로고
    • PD-1 inhibits antiviral immunity at the effector phase in the liver
    • Iwai Y., Terawaki S., Ikegawa M., Okazaki T., and Honjo T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 198 (2003) 39-50
    • (2003) J. Exp. Med. , vol.198 , pp. 39-50
    • Iwai, Y.1    Terawaki, S.2    Ikegawa, M.3    Okazaki, T.4    Honjo, T.5
  • 10
    • 0017333928 scopus 로고
    • Immune response to immunization via the anterior chamber of the eye. I.F. lymphocyte-induced immune deviation
    • Kaplan H.J., and Streilein J.W. Immune response to immunization via the anterior chamber of the eye. I.F. lymphocyte-induced immune deviation. J. Immunol. 118 (1977) 809-814
    • (1977) J. Immunol. , vol.118 , pp. 809-814
    • Kaplan, H.J.1    Streilein, J.W.2
  • 11
    • 0017813457 scopus 로고
    • Immune response to immunization via the anterior chamber of the eye. II. An analysis of F1 lymphocyte-induced immune deviation
    • Kaplan H.J., and Streilein J.W. Immune response to immunization via the anterior chamber of the eye. II. An analysis of F1 lymphocyte-induced immune deviation. J. Immunol. 120 (1978) 689-693
    • (1978) J. Immunol. , vol.120 , pp. 689-693
    • Kaplan, H.J.1    Streilein, J.W.2
  • 12
    • 26944439764 scopus 로고    scopus 로고
    • Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye
    • Kim C.Y., Masli S., and Streilein J.W. Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye. Ocul. Immunol. Inflamm. 13 (2005) 271-277
    • (2005) Ocul. Immunol. Inflamm. , vol.13 , pp. 271-277
    • Kim, C.Y.1    Masli, S.2    Streilein, J.W.3
  • 13
    • 58149191881 scopus 로고    scopus 로고
    • The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    • Kinter A.L., Godbout E.J., McNally J.P., Sereti I., Roby G.A., O'Shea M.A., and Fauci A.S. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J. Immunol. 181 (2008) 6738-6746
    • (2008) J. Immunol. , vol.181 , pp. 6738-6746
    • Kinter, A.L.1    Godbout, E.J.2    McNally, J.P.3    Sereti, I.4    Roby, G.A.5    O'Shea, M.A.6    Fauci, A.S.7
  • 14
    • 0025739893 scopus 로고
    • Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells
    • Knisely T.L., Bleicher P.A., Vibbard C.A., and Granstein R.D. Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells. Curr. Eye Res. 10 (1991) 761-771
    • (1991) Curr. Eye Res. , vol.10 , pp. 761-771
    • Knisely, T.L.1    Bleicher, P.A.2    Vibbard, C.A.3    Granstein, R.D.4
  • 16
    • 0027260894 scopus 로고
    • Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms
    • Liversidge J., McKay D., Mullen G., and Forrester J.V. Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms. Cell Immunol. 149 (1993) 315-330
    • (1993) Cell Immunol. , vol.149 , pp. 315-330
    • Liversidge, J.1    McKay, D.2    Mullen, G.3    Forrester, J.V.4
  • 19
    • 0036851922 scopus 로고    scopus 로고
    • Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2
    • Namba K., Kitaichi N., Nishida T., and Taylor A.W. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2. J. Leukoc. Biol. 72 (2002) 946-952
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 946-952
    • Namba, K.1    Kitaichi, N.2    Nishida, T.3    Taylor, A.W.4
  • 20
    • 0021073187 scopus 로고
    • Alloantigens placed into the anterior chamber of the eye induce specific suppression of delayed-type hypersensitivity but normal cytotoxic T lymphocyte and helper T lymphocyte responses
    • Niederkorn J.Y., and Streilein J.W. Alloantigens placed into the anterior chamber of the eye induce specific suppression of delayed-type hypersensitivity but normal cytotoxic T lymphocyte and helper T lymphocyte responses. J. Immunol. 131 (1983) 2670-2674
    • (1983) J. Immunol. , vol.131 , pp. 2670-2674
    • Niederkorn, J.Y.1    Streilein, J.W.2
  • 22
    • 0031685190 scopus 로고    scopus 로고
    • Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses
    • Nishimura H., Minato N., Nakano T., and Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol. 10 (1998) 1563-1572
    • (1998) Int. Immunol. , vol.10 , pp. 1563-1572
    • Nishimura, H.1    Minato, N.2    Nakano, T.3    Honjo, T.4
  • 23
    • 33645863160 scopus 로고    scopus 로고
    • The PD-1-PD-L pathway in immunological tolerance
    • Okazaki T., and Honjo T. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol. 27 (2006) 195-201
    • (2006) Trends Immunol. , vol.27 , pp. 195-201
    • Okazaki, T.1    Honjo, T.2
  • 24
    • 0242584894 scopus 로고    scopus 로고
    • B7 family molecules are favorably positioned at the human maternal-fetal interface
    • Petroff M.G., Chen L., Phillips T.A., Azzola D., Sedlmayr P., and Hunt J.S. B7 family molecules are favorably positioned at the human maternal-fetal interface. Biol. Reprod. 68 (2003) 1496-1504
    • (2003) Biol. Reprod. , vol.68 , pp. 1496-1504
    • Petroff, M.G.1    Chen, L.2    Phillips, T.A.3    Azzola, D.4    Sedlmayr, P.5    Hunt, J.S.6
  • 26
    • 35748972357 scopus 로고    scopus 로고
    • The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival
    • Shen L., Jin Y., Freeman G.J., Sharpe A.H., and Dana M.R. The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival. J. Immunol. 179 (2007) 3672-3679
    • (2007) J. Immunol. , vol.179 , pp. 3672-3679
    • Shen, L.1    Jin, Y.2    Freeman, G.J.3    Sharpe, A.H.4    Dana, M.R.5
  • 27
    • 0242636366 scopus 로고    scopus 로고
    • Ocular immune privilege: therapeutic opportunities from an experiment of nature
    • Streilein J.W. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat. Rev. Immunol. 3 (2003) 879-889
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 879-889
    • Streilein, J.W.1
  • 28
    • 0025787992 scopus 로고
    • Analysis of immunosuppressive properties of iris and ciliary body cells and their secretory products
    • Streilein J.W., and Bradley D. Analysis of immunosuppressive properties of iris and ciliary body cells and their secretory products. Invest. Ophthalmol. Vis. Sci. 32 (1991) 2700-2710
    • (1991) Invest. Ophthalmol. Vis. Sci. , vol.32 , pp. 2700-2710
    • Streilein, J.W.1    Bradley, D.2
  • 29
    • 0018944567 scopus 로고
    • Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens
    • Streilein J.W., Niederkorn J.Y., and Shadduck J.A. Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens. J. Exp. Med. 152 (1980) 1121-1125
    • (1980) J. Exp. Med. , vol.152 , pp. 1121-1125
    • Streilein, J.W.1    Niederkorn, J.Y.2    Shadduck, J.A.3
  • 31
    • 1642310491 scopus 로고    scopus 로고
    • CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation
    • Sugita S., Ng T.F., Schwartzkopff J., and Streilein J.W. CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation. J. Immunol. 172 (2004) 4184-4194
    • (2004) J. Immunol. , vol.172 , pp. 4184-4194
    • Sugita, S.1    Ng, T.F.2    Schwartzkopff, J.3    Streilein, J.W.4
  • 34
    • 0037815115 scopus 로고    scopus 로고
    • Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4
    • Sugita S., and Streilein J.W. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 198 (2003) 161-171
    • (2003) J. Exp. Med. , vol.198 , pp. 161-171
    • Sugita, S.1    Streilein, J.W.2
  • 35
    • 0027415806 scopus 로고
    • Identification of transforming growth factor-beta expressed in cultured human retinal pigment epithelial cells
    • Tanihara H., Yoshida M., Matsumoto M., and Yoshimura N. Identification of transforming growth factor-beta expressed in cultured human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 34 (1993) 413-419
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 413-419
    • Tanihara, H.1    Yoshida, M.2    Matsumoto, M.3    Yoshimura, N.4
  • 36
    • 0027055407 scopus 로고
    • Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor
    • Taylor A.W., Streilein J.W., and Cousins S.W. Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. Curr. Eye Res. 11 (1992) 1199-1206
    • (1992) Curr. Eye Res. , vol.11 , pp. 1199-1206
    • Taylor, A.W.1    Streilein, J.W.2    Cousins, S.W.3
  • 37
    • 0028361144 scopus 로고
    • Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor
    • Taylor A.W., Streilein J.W., and Cousins S.W. Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. J. Immunol. 153 (1994) 1080-1086
    • (1994) J. Immunol. , vol.153 , pp. 1080-1086
    • Taylor, A.W.1    Streilein, J.W.2    Cousins, S.W.3
  • 38
    • 0031779801 scopus 로고    scopus 로고
    • Suppression of nitric oxide generated by inflammatory macrophages by calcitonin gene-related peptide in aqueous humor
    • Taylor A.W., Yee D.G., and Streilein J.W. Suppression of nitric oxide generated by inflammatory macrophages by calcitonin gene-related peptide in aqueous humor. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1372-1378
    • (1998) Invest. Ophthalmol. Vis. Sci. , vol.39 , pp. 1372-1378
    • Taylor, A.W.1    Yee, D.G.2    Streilein, J.W.3
  • 41
    • 33748101272 scopus 로고    scopus 로고
    • Differential effects of costimulatory pathway modulation on corneal allograft survival
    • Watson M.P., George A.J., and Larkin D.F. Differential effects of costimulatory pathway modulation on corneal allograft survival. Invest. Ophthalmol. Vis. Sci. 47 (2006) 3417-3422
    • (2006) Invest. Ophthalmol. Vis. Sci. , vol.47 , pp. 3417-3422
    • Watson, M.P.1    George, A.J.2    Larkin, D.F.3
  • 42
    • 27544505241 scopus 로고    scopus 로고
    • Muscle-derived positive and negative regulators of the immune response
    • Wiendl H., Hohlfeld R., and Kieseier B.C. Muscle-derived positive and negative regulators of the immune response. Curr. Opin. Rheumatol. 17 (2005) 714-719
    • (2005) Curr. Opin. Rheumatol. , vol.17 , pp. 714-719
    • Wiendl, H.1    Hohlfeld, R.2    Kieseier, B.C.3
  • 43
    • 0026571065 scopus 로고
    • Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-beta
    • Wilbanks G.A., Mammolenti M., and Streilein J.W. Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-beta. Eur. J. Immunol. 22 (1992) 165-173
    • (1992) Eur. J. Immunol. , vol.22 , pp. 165-173
    • Wilbanks, G.A.1    Mammolenti, M.2    Streilein, J.W.3
  • 45
    • 0033764314 scopus 로고    scopus 로고
    • Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 2. Generation of TGF-beta-producing regulatory T cells
    • Yoshida M., Kezuka T., and Streilein J.W. Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 2. Generation of TGF-beta-producing regulatory T cells. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3862-3870
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 3862-3870
    • Yoshida, M.1    Kezuka, T.2    Streilein, J.W.3
  • 46
    • 0034055525 scopus 로고    scopus 로고
    • Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell contact
    • Yoshida M., Takeuchi M., and Streilein J.W. Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell contact. Invest Ophthalmol. Vis. Sci. 41 (2000) 811-821
    • (2000) Invest Ophthalmol. Vis. Sci. , vol.41 , pp. 811-821
    • Yoshida, M.1    Takeuchi, M.2    Streilein, J.W.3


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