Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo

Investigational New Drugs

Volumn 27, Issue 4, 2009, Pages 304-318

  Myers, Tashanna ^a   Chengedza, Shylet ^a   Lightfoot, Stan ^a   Pan, Yanfang ^a   Dedmond, Daynelle ^a   Cole, Lauren ^a   Tang, Yuhong ^b,c   Benbrook, Doris M ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c PLANT BIOLOGY DIVISION   (United States)

Author keywords

Angiogenesis; Basic fibroblast growth factor; Heteroarotinoid; Thrombospondin 4; Thymidine phosphorylase; Vascular endothelial growth factor

Indexed keywords

[(4 NITROPHENYL)AMINO][2,2,4,4 TETRAMETHYLTHIOCHROMAN 6 YL)AMINO]METHANETHIONE] DERIVATIVE; ANTINEOPLASTIC AGENT; AROTINOID; BASIC FIBROBLAST GROWTH FACTOR; CYTOKINE; HETEROAROTINOID DERIVATIVE; PROTEIN; RECOMBINANT PROTEIN; RECOMBINANT THYMIDINE PHOSPHORYLASE; SHETA2; THROMBOSPONDIN 4; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CULTURE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEOVASCULARIZATION, PATHOLOGIC; THIONES; THYMIDINE PHOSPHORYLASE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 67651181068     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9175-7     Document Type: Article

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