Elevated activated partial thromboplastin time does not correlate with heparin rebound following cardiac surgery

Canadian Journal of Anesthesia

Volumn 56, Issue 7, 2009, Pages 489-496

  Taneja, Ravi ^a   Marwaha, Gulshan ^a   Sinha, Prabhat ^a   Quantz, MacKenzie ^a   Stitt, Larry ^a   Gao, Rouchu ^a   Subramanian, Seetha ^a   Schaus, Maureen ^a   Keeney, Mike ^a   Chin Yee, Ian ^a   Murkin, John ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CLOPIDOGREL; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PROTAMINE SULFATE; PROTEIN ANTIBODY; PROTHROMBIN; THROMBIN INHIBITOR; THROMBOPLASTIN; TRANEXAMIC ACID; WARFARIN;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BLOOD CLOTTING TIME; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ADSORPTION; DRUG BLOOD LEVEL; FEMALE; HEART SURGERY; HUMAN; INTENSIVE CARE; INTERNATIONAL NORMALIZED RATIO; MALE; PARTIAL THROMBOPLASTIN TIME; PILOT STUDY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTHROMBIN TIME; REBOUND;

AGED; ANTICOAGULANTS; BLOOD COAGULATION TESTS; CARDIOPULMONARY BYPASS; FACTOR XA; FEMALE; HEPARIN; HUMANS; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PILOT PROJECTS; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; TIME FACTORS; WHOLE BLOOD COAGULATION TIME;

EID: 67651166637     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12630-009-9098-6     Document Type: Article

References (53)

1. MJ Unsworth-White A Herriot O Valencia 1995 Resternotomy for bleeding after cardiac operation: a marker for increased morbidity and mortality Ann Thorac Surg 59 664 667
2. M Sellman MA Intonti T Ivert 1997 Reoperations for bleeding after coronary artery bypass procedures during 25 years Eur J Cardiothorac Surg 11 521 527 (Pubitemid 27146164)
3. JJ Munoz NJ Birkmeyer LJ Dacey JD Birkmeyer DC Charlesworth ER Johnson 1999 Trends in rates of reexploration for hemorrhage after coronary artery bypass surgery Northern New England Cardiovascular Disease Study Group Ann Thorac Surg 68 1321 1325
4. K Karkouti DN Wijeysundera TM Yau 2004 The independent association of massive blood loss with mortality in cardiac surgery Transfusion 44 1453 1462 (Pubitemid 39318980)
5. CG Koch L Li DR Van Wagoner AI Duncan AM Gillinov EH Blackstone 2006 Red cell transfusion is associated with an increased risk for postoperative atrial fibrillation Ann Thorac Surg 82 1747 1756 (Pubitemid 44596264)
6. CG Koch L Li DI Sessler P Figueroa GA Hoeltge T Mihaljevic EH Blackstone 2008 Duration of red-cell storage and complications after cardiac surgery N Engl J Med 358 1229 1239
7. D Paparella SJ Brister MR Buchanan 2004 Coagulation disorders of cardiopulmonary bypass: a review Intensive Care Med 30 1873 1881 (Pubitemid 39468407)
8. L Shore-Lesserson DL Reich M DePerio 1998 Heparin and protamine titration do not improve haemostasis in cardiac surgical patients Can J Anaesth 45 10 18 (Pubitemid 28135229)
9. DR Jobes GL Aitken GW Shaffer 1995 Increased accuracy and precision of heparin and protamine dosing reduces blood loss and transfusion in patients undergoing primary cardiac operations J Thorac Cardiovasc Surg 110 36 45
10. GJ Despotis AL Summerfield JH Joist 1994 Comparison of activated coagulation time and whole blood heparin measurements with laboratory plasma anti-Xa heparin concentration in patients having cardiac operations J Thorac Cardiovasc Surg 108 1076 1082 (Pubitemid 24379861)
11. P Martin F Horkay NK Gupta C Gebitekin DR Walker 1992 Heparin rebound phenomenon-much ado about nothing? Blood Coagul Fibrinolysis 3 187 191
12. GP Gravlee AT Rogers LM Dudas 1992 Heparin management protocol for cardiopulmonary bypass influences postoperative heparin rebound but not bleeding Anesthesiology 76 393 401
13. RA Esposito AT Culliford SB Colvin SJ Thomas H Lackner FC Spencer 1983 Heparin resistance during cardiopulmonary bypass. The role of heparin pretreatment J Thorac Cardiovasc Surg 85 346 353
14. KH Teoh E Young MH Blackall RS Roberts J Hirsh 2004 Can extra protamine eliminate heparin rebound following cardiopulmonary bypass surgery? J Thorac Cardiovasc Surg 128 211 219 (Pubitemid 38969802)
15. R Taneja P Fernandes G Marwaha D Cheng D Bainbridge 2008 Perioperative coagulation management and blood conservation in cardiac surgery: a Canadian survey J Cardiothorac Vasc Anesth 22 662 669
16. RM Barstad RW Stephens MJ Hamers KS Sakariassen 2000 Protamine sulphate inhibits platelet membrane glycoprotein Ib-von Willebrand factor activity Thromb Haemost 83 334 337 (Pubitemid 30093241)
17. T Mochizuki PJ Olson F Szlam JG Ramsay JH Levy 1998 Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass Anesth Analg 87 781 785 (Pubitemid 28455470)
18. M Nybo JS Madsen 2008 Serious anaphylactic reactions due to protamine sulfate: a systematic literature review Basic Clin Pharmacol Toxicol 103 192 196 (Pubitemid 352019729)
19. VG Nielsen 2006 Protamine enhances fibrinolysis by decreasing clot strength: role of tissue factor-initiated thrombin generation Ann Thorac Surg 81 1720 1727 (Pubitemid 350030024)
20. LM Palermo RW Andrews N Ellison 1980 Avoidance of heparin contamination in coagulation studies drawn from indwelling lines Anesth Analg 59 222 224 (Pubitemid 10114521)
21. Santoro S, Eby C. Laboratory evaluation of hemostatic disease. In: Hoffman R, editor. Hematology-Basic Principles and Practice. 3rd ed. Philadelphia: Churchill Livingstone; 2000. p. 1841-9.
22. Armitage P, Berry G. Statistical Methods in Research, vol. 2. Oxford: Backwell Scientific Publications; 1987.
23. Snedecor G, Cochran G. Statistical Methods, vol. 6. Iowa: The Iowa State Press; 1967.
24. J Hirsh TE Warkentin SG Shaughnessy 2001 Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety Chest 119 64S 94S (Pubitemid 32154195)
25. G Ramsey DA Arvan S Stewart N Blumberg 1983 Do preoperative laboratory tests predict blood transfusion needs in cardiac operations? J Thorac Cardiovasc Surg 85 564 569
26. GA Nuttall WC Oliver FM Beynen PJ Santrach RA Strickland MJ Murray 1995 Determination of normal versus abnormal activated partial thromboplastin time and prothrombin time after cardiopulmonary bypass J Cardiothorac Vasc Anesth 9 355 361
27. GJ Despotis KS Filos TN Zoys CW Hogue Jr E Spitznagel DG Lappas 1996 Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: a multivariate analysis in cardiac surgical patients Anesth Analg 82 13 21 (Pubitemid 26017375)
28. GA Nuttall WC Oliver MH Ereth PJ Santrach 1997 Coagulation tests predict bleeding after cardiopulmonary bypass J Cardiothorac Vasc Anesth 11 815 823 (Pubitemid 27523082)
29. JJ Chavez JS Weatherall SM Strevels F Liu CC Snider RC Carroll 2004 Evaluation of a point-of-care coagulation analyzer on patients undergoing cardiopulmonary bypass surgery J Clin Anesth 16 7 10 (Pubitemid 38251468)
30. M Blome F Isgro AH Kiessling 2005 Relationship between factor XIII activity, fibrinogen, haemostasis screening tests and postoperative bleeding in cardiopulmonary bypass surgery Thromb Haemost 93 1101 1107 (Pubitemid 40823515)
31. CV Bishop WE Renwick C Hogan M Haeusler A Tuckfield J Tatoulis 2006 Recombinant activated factor VII: treating postoperative hemorrhage in cardiac surgery Ann Thorac Surg 81 875 879 (Pubitemid 43247653)
32. IJ Welsby K Jiao TL Ortel 2006 The kaolin-activated thrombelastograph predicts bleeding after cardiac surgery J Cardiothorac Vasc Anesth 20 531 535 (Pubitemid 44119258)
33. SK Chong SP Kum JY Mi OK Kyoung 2006 Effects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trial Acta Anaesthesiol Scand 50 108 111 (Pubitemid 43339039)
34. G Niranjan G Asimakopoulos A Karagounis G Cockerill M Thompson V Chandrasekaran 2006 Effects of cell saver autologous blood transfusion on blood loss and homologous blood transfusion requirements in patients undergoing cardiac surgery on- versus off-cardiopulmonary bypass: a randomised trial Eur J Cardiothorac Surg 30 271 277 (Pubitemid 44051933)
35. R Mohr U Martinowitz M Golan L Ayala DA Goor B Ramot 1986 Platelet size and mass as an indicator for platelet transfusion after cardiopulmonary bypass Circulation 74 III153 III158
36. SF Khuri JA Wolfe M Josa 1992 Hematologic changes during and after cardiopulmonary bypass and their relationship to the bleeding time and nonsurgical blood loss J Thorac Cardiovasc Surg 104 94 107
37. JH Essell TJ Martin J Salinas JM Thompson VC Smith 1993 Comparison of thromboelastography to bleeding time and standard coagulation tests in patients after cardiopulmonary bypass J Cardiothorac Vasc Anesth 7 410 415 (Pubitemid 23231393)
38. GP Gravlee S Arora SW Lavender 1994 Predictive value of blood clotting tests in cardiac surgical patients Ann Thorac Surg 58 216 221 (Pubitemid 24243933)
39. GA Nuttall WC Oliver Jr FM Beynen JJ Dull MJ Murray WL Nichols 1993 Intraoperative measurement of activated partial thromboplastin time and prothrombin time by a portable laser photometer in patients following cardiopulmonary bypass J Cardiothorac Vasc Anesth 7 402 409 (Pubitemid 23231392)
40. BE Miller T Mochizuki JH Levy 1997 Predicting and treating coagulopathies after cardiopulmonary bypass in children Anesth Analg 85 1196 1202 (Pubitemid 28130510)
41. JD Olson CF Arkin JT Brandt 1998 College of American Pathologists Conference XXXI on laboratory monitoring of anticoagulant therapy: laboratory monitoring of unfractionated heparin therapy Arch Pathol Lab Med 122 782 798
42. DE Nelson 1999 Current considerations in the use of the APTT in monitoring unfractionated heparin Clin Lab Sci 12 359 364
43. DM Adcock DC Kressin RA Marlar 1997 Effect of 32% vs. 38% sodium citrate concentration on routine coagulation testing Am J Clin Pathol 107 105 110 (Pubitemid 27104645)
44. P Brill-Edwards JS Ginsberg M Johnston J Hirsh 1993 Establishing a therapeutic range for heparin therapy Ann Intern Med 119 104 109 (Pubitemid 23286474)
45. DJ Murray WJ Brosnahan B Pennell D Kapalanski JM Weiler J Olson 1997 Heparin detection by the activated coagulation time: a comparison of the sensitivity of coagulation tests and heparin assays J Cardiothorac Vasc Anesth 11 24 28 (Pubitemid 27114203)
46. GJ Despotis JH Joist CW Hogue Jr 1996 More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT Thromb Haemost 76 902 908 (Pubitemid 27013627)
47. DH Bevan 1999 Cardiac bypass haemostasis: putting blood through the mill Br J Haematol 104 208 219 (Pubitemid 29083326)
48. M Inagaki K Goto H Katayama KT Benson H Goto K Arakawa 1989 Activated partial thromboplastin time-protamine dose relation in the presence and absence of heparin J Cardiothorac Anesth 3 734 736 (Pubitemid 20029352)
49. ME Carr Jr SL Carr 1994 At high heparin concentrations, protamine concentrations which reverse heparin anticoagulant effects are insufficient to reverse heparin anti-platelet effects Thromb Res 75 617 630
50. A Perkash 1980 A comparison of the quantitative action of protamine and heparin on blood coagulation. Significance in clinical and laboratory usage Am J Clin Pathol 73 676 681 (Pubitemid 10047201)
51. JF Hardy S Belisle D Robitaille J Perrault M Roy L Gagnon 1996 Measurement of heparin concentration in whole blood with the Hepcon/HMS device does not agree with laboratory determination of plasma heparin concentration using a chromogenic substrate for activated factor X J Thorac Cardiovasc Surg 112 154 161 (Pubitemid 26268982)
52. L Shore-Lesserson 1997 Transfusion algorithms: more than just alphabet soup? J Cardiothorac Vasc Anesth 11 813 814
53. J Butterworth YA Lin R Prielipp J Bennett 2002 James R The pharmacokinetics and cardiovascular effects of a single intravenous dose of protamine in normal volunteers Anesth Analg 94 514 522 (Pubitemid 34177542)