Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway

Journal of Neural Transmission

Volumn 116, Issue 7, 2009, Pages 841-852

  Hamada, Nanako ^a   Fujita, Yasunori ^a   Tanaka, Arisa ^a   Naoi, Makoto ^a   Nozawa, Yoshinori ^a   Ono, Yoshiko ^b   Kitagawa, Yoshinori ^b   Tomimori, Namino ^b   Kiso, Yoshinobu ^b   Ito, Masafumi ^a  

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b SUNTORY LTD   (Japan)

Author keywords

ERK1 2 MAPK signaling pathway; Nerve growth factor; Neuronal differentiation; PC12 cells; Sesame; Sesamin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (3,4 METHYLENEDIOXYPHENYL) 6 (3 METOXY 4 HYDROXYPHENYL) 3,7 DIOXABICYCLO[3.3.0]OCTANE; 2 (3,4 METHYLENEDIOXYPHENYL) 6 (3,4 DIHYDROXYPHENYL) 3,7 DIOXABICYCLO [3.3.0]OCTANE; 2,6 BIS(3,4 DIHYDROXYPHENYL) 3,7 DIOXABICYCLO[3.3.0]OCTANE; 2,6 BIS(3,4 DIMETHYLENEDIOXYPHENYL) 3,7 DIOXABICYCLO[3.3.0]OCTANE; EPISESAMIN; K 252A; LIGNAN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE GROWTH FACTOR; PROTEIN TYROSINE KINASE A; SESAMIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL STRAIN; CONTROLLED STUDY; DEGENERATIVE DISEASE; METABOLITE; MOUSE; NERVE CELL DIFFERENTIATION; NEURITE; NEUROPROTECTION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

ANIMALS; ANTIOXIDANTS; CELL DIFFERENTIATION; DIOXOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; LIGNANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; NERVE GROWTH FACTOR; NEURAL PATHWAYS; NEUROGENESIS; NEURONS; PC12 CELLS; PHOSPHORYLATION; RATS; RECEPTOR, TRKA; SYNAPSES; SYNAPTOPHYSIN;

EID: 67651166606     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-009-0250-9     Document Type: Article

References (48)

1. K Akimoto Y Kitagawa T Akamatsu N Hirose M Sugano S Shimizu H Yamada 1993 Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents Ann Nutr Metab 37 218 224
2. RT Bartus RL Dean 3rd B Beer AS Lippa 1982 The cholinergic hypothesis of geriatric memory dysfunction Science 217 408 414
3. A Cattaneo S Capsoni F Paoletti 2008 Towards non invasive nerve growth factor therapies for Alzheimer's disease J Alzheimers Dis 15 255 283
4. S Cowley H Paterson P Kemp CJ Marshall 1994 Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells Cell 77 841 852
5. KP Das TM Freudenrich WR Mundy 2004 Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures Neurotoxicol Teratol 26 397 406
6. P Davies AJ Maloney 1976 Selective loss of central cholinergic neurons in Alzheimer's disease Lancet 2 1403
7. W Fischer K Wictorin A Bjorklund LR Williams S Varon FH Gage 1987 Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor Nature 329 65 68
8. T Fujikawa N Kanada A Shimada M Ogata I Suzuki I Hayashi K Nakashima 2005 Effect of sesamin in Acanthopanax senticosus HARMS on behavioral dysfunction in rotenone-induced parkinsonian rats Biol Pharm Bull 28 169 172
9. N Fukuda L Zhang M Kodama M Sakono T Ide K Yamamoto M Sugano 1999 Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver J Nutr Sci Vitaminol (Tokyo) 45 437 448
10. LA Greene AS Tischler 1976 Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor Proc Natl Acad Sci USA 73 2424 2428
11. F Hefti WJ Weiner 1986 Nerve growth factor and Alzheimer's disease Ann Neurol 20 275 281
12. N Hirose T Inoue K Nishihara M Sugano K Akimoto S Shimizu H Yamada 1991 Inhibition of cholesterol absorption and synthesis in rats by sesamin J Lipid Res 32 629 638
13. RC Hou HM Huang JT Tzen KC Jeng 2003 Protective effects of sesamin and sesamolin on hypoxic neuronal, PC12 cells J Neurosci Res 74 123 133
14. JY Hur P Lee H Kim I Kang KR Lee SY Kim 2004 (-)-3, 5-Dicaffeoyl-muco- quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells: through tyrosine kinase cascade signaling Biochem Biophys Res Commun 313 948 953
15. S Jing P Tapley M Barbacid 1992 Nerve growth factor mediates signal transduction through trk homodimer receptors Neuron 9 1067 1079
16. Y Kamei CK Tsang 2003 Sargaquinoic acid promotes neurite outgrowth via protein kinase A and MAP kinases-mediated signaling pathways in PC12D cells Int J Dev Neurosci 21 255 262
17. Y Kiso 2004 Antioxidative roles of sesamin, a functional lignan in sesame seed, and it's effect on lipid- and alcohol-metabolism in the liver: a DNA microarray study Biofactors 21 191 196
18. S Kita Y Matsumura S Morimoto K Akimoto M Furuya N Oka T Tanaka 1995 Antihypertensive effect of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy Biol Pharm Bull 18 1283 1285
19. S Koizumi ML Contreras Y Matsuda T Hama P Lazarovici G Guroff 1988 K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells J Neurosci 8 715 721 (Pubitemid 18078094)
20. P Lazarovici BZ Levi PI Lelkes S Koizumi K Fujita Y Matsuda K Ozato G Guroff 1989 K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells J Neurosci Res 23 1 8
21. P Li K Matsunaga K Yamamoto R Yoshikawa K Kawashima Y Ohizumi 1999 Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells Neurosci Lett 273 53 56
22. P Li K Matsunaga T Yamakuni Y Ohizumi 2000 Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells Eur J Pharmacol 406 203 208
23. AC Maroney L Lipfert ME Forbes MA Glicksman NT Neff R Siman CA Dionne 1995 K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells J Neurochem 64 540 549
24. Y Matsumura Y Egi H Maekawa A Miura S Murata S Morimoto 1995 Enhancement of norepinephrine and angiotensin II-induced renal effects by NG-nitro-l-arginine, a nitric oxide synthase inhibitor Biol Pharm Bull 18 496 500
25. Y Matsumura S Kita S Morimoto K Akimoto M Furuya N Oka T Tanaka 1995 Antihypertensive effect of sesamin. I. Protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy Biol Pharm Bull 18 1016 1019
26. M Nakai M Harada K Nakahara K Akimoto H Shibata W Miki Y Kiso 2003 Novel antioxidative metabolites in rat liver with ingested sesamin J Agric Food Chem 51 1666 1670
27. D Nakano CJ Kwak K Fujii 2006 Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: possible involvement of the metabolites in the antihypertensive effect of sesamin J Pharmacol Exp Ther 318 328 335
28. A Obermeier R Lammers KH Wiesmuller G Jung J Schlessinger A Ullrich 1993 Identification of Trk binding sites for SHC and phosphatidylinositol 3-kinase and formation of a multimeric signaling complex J Biol Chem 268 22963 22966
29. A Obermeier RA Bradshaw K Seedorf A Choidas J Schlessinger A Ullrich 1994 Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma Embo J 13 1585 1590
30. L Pang T Sawada SJ Decker AR Saltiel 1995 Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor J Biol Chem 270 13585 13588
31. JL Penalvo A Hopia H Adlercreutz 2006 Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice Eur J Nutr 45 439 444
32. L Reznichenko T Amit MB Youdim S Mandel 2005 Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth J Neurochem 93 1157 1167
33. PP Roux G Dorval M Boudreau A Angers-Loustau SJ Morris J Makkerh PA Barker 2002 K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK J Biol Chem 277 49473 49480
34. DJ Selkoe 2002 Alzheimer's disease is a synaptic failure Science 298 789 791
35. T Shibata H Nakahara N Kita 2008 A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction J Neurochem 107 1248 1260
36. RM Stephens DM Loeb TD Copeland T Pawson LA Greene DR Kaplan 1994 Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses Neuron 12 691 705
37. Y Suzaki M Yoshizumi S Kagami AH Koyama Y Taketani H Houchi K Tsuchiya E Takeda T Tamaki 2002 Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults J Biol Chem 277 9614 9621
38. RD Terry E Masliah DP Salmon N Butters R DeTeresa R Hill LA Hansen R Katzman 1991 Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment Ann Neurol 30 572 580
39. Traverse S, Gomez N, Paterson H, Marshall C, Cohen P (1992) Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem J 288(Pt 2):351-355
40. CK Tsang A Ina T Goto Y Kamei 2005 Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells Neuroscience 132 633 643
41. M Tsuji O Inanami M Kuwabara 2001 Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway J Biol Chem 276 32779 32785 (Pubitemid 37384724)
42. MH Tuszynski L Thal M Pay 2005 A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease Nat Med 11 551 555
43. PJ Whitehouse DL Price RG Struble AW Clark JT Coyle MR Delon 1982 Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain Science 215 1237 1239
44. M Yamazaki K Chiba T Mohri 1996 Neuritogenic effect of natural iridoid compounds on PC12h cells and its possible relation to signaling protein kinases Biol Pharm Bull 19 791 795
45. YJ Yang HJ Lee DH Choi HS Huang SC Lim MK Lee 2008 Effect of scoparone on neurite outgrowth in PC12 cells Neurosci Lett 440 14 18
46. R Yao GM Cooper 1995 Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor Science 267 2003 2006
47. LA Yeh D Padmanaban P Ho X Xing P Rowley LJ Morse RV Jensen GD Cuny 2005 Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression Bioorg Med Chem Lett 15 1193 1196
48. GY Zhang QG Zhang 2005 Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants Expert Opin Investig Drugs 14 1373 1383