Ovarian cancer-derived glycodelin impairs in vitro dendritic cell maturation

Journal of Immunotherapy

Volumn 32, Issue 5, 2009, Pages 492-497

  Scholz, Christoph ^a   Rampf, Elisabeth ^a   Toth, Bettina ^b   Brunnhuber, Regina ^a   Weissenbacher, Tobias ^a   Friese, Klaus ^a,b   Jeschke, Udo ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Dendritic cells; Epithelial ovarian cancer; Glycodelin; Pregnancy glycoproteins; Tumor micromilieu

Indexed keywords

CD209 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 1BETA; PLACENTA PROTEIN 14; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ASCITES; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IN VITRO STUDY; OVARY CANCER; PHENOTYPE; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-BETA; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; OVARIAN NEOPLASMS; PREGNANCY; PREGNANCY PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67651158916     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181a59fa9     Document Type: Article

References (44)

1. Rabinovich GA, Gabrilovich D, Sotomayor EM. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol. 2007;25:267-296.
2. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685-711.
3. Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004; 10:942-949.
4. Eisenthal A, Polyvkin N, Bramante-Schreiber L, et al. Expression of dendritic cells in ovarian tumors correlates with clinical outcome in patients with ovarian cancer. Hum Pathol. 2001;32:803-807.
5. Curiel TJ, Wei S, Dong H, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med. 2003;9:562-567.
6. Macagno A, Napolitani G, Lanzavecchia A, et al. Duration, combination and timing: the signal integration model of dendritic cell activation. Trends Immunol. 2007;28:227-233.
7. Matzinger P. An innate sense of danger. Ann N Y Acad Sci. 2002;961:341-342.
8. Hernando JJ, Park TW, Fischer HP, et al. Vaccination with dendritic cells transfected with mRNA-encoded folate-receptoralpha for relapsed metastatic ovarian cancer. Lancet Oncol. 2007;8:451-454.
9. Seppala M, Taylor RN, Koistinen H, et al. Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Endocr Rev. 2002; 23:401-430.
10. Song M, Ramaswamy S, Ramachandran S, et al. Angiogenic role for glycodelin in tumorigenesis. Proc Natl Acad Sci USA. 2001;98:9265-9270.
11. Mandelin E, Lassus H, Seppala M, et al. Glycodelin in ovarian serous carcinoma: association with differentiation and survival. Cancer Res. 2003;63:6258-6264.
12. Havrilesky LJ, Whitehead CM, Rubatt JM, et al. Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence. Gynecol Oncol. 2008; 110:374-382. Epub 2008 June 27.
13. +-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells. Glycobiology. 2006; 16:173-183.
14. Okamoto N, Uchida A, Takakura K, et al. Suppression by human placental protein 14 of natural killer cell activity. Am J Reprod Immunol. 1991;26:137-142.
15. Rachmilewitz J, Riely GJ, Tykocinski ML. Placental protein 14 functions as a direct T-cell inhibitor. Cell Immunol. 1999;191:26-33.
16. Scholz C, Toth B, Brunnhuber R, et al. Glycodelin A induces a tolerogenic phenotype in monocyte-derived dendritic cells in vitro. Am J Reprod Immunol. 2008; 60:501-512.
17. Miller RE, Fayen JD, Chakraborty S, et al. A receptor for the lipocalin placental protein 14 on human monocytes. FEBS Lett. 1998;436:455-460.
18. Sallusto F, Lanzavecchia A. E.cient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994;179:1109-1118.
19. Jeschke U, Kuhn C, Mylonas I, et al. Development and characterization of monoclonal antibodies for the immunohistochemical detection of glycodelin A in decidual, endometrial and gynaecological tumour tissues. Histopathology. 2006; 48:394-406.
20. Vigne JL, Hornung D, Mueller MD, et al. Purification and characterization of an immunomodulatory endometrial protein, glycodelin. J Biol Chem. 2001;276:17101-17105.
21. Jeschke U, Mylonas I, Kunert-Keil C, et al. Immunohistochemistry, glycosylation and immunosuppression of glycodelin in human ovarian cancer. Histochem Cell Biol. 2009; 131:283-295.
22. Schnurr M, Then F, Galambos P, et al. Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells. J Immunol. 2000;165:4704-4709.
23. Sallusto F, Cella M, Danieli C, et al. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products [see comments]. J Exp Med. 1995;182:389-400.
24. Snijders A, Kalinski P, Hilkens CM, et al. High-level IL-12 production by human dendritic cells requires two signals. Int Immunol. 1998;10:1593-1598.
25. Li G, Kim YJ, Broxmeyer HE. Macrophage colony-stimulating factor drives cord blood monocyte differentiation into IL-10 (high) IL-12absent dendritic cells with tolerogenic potential. J Immunol. 2005;174:4706-4717.
26. Soilleux EJ, Morris LS, Leslie G, et al. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J Leukoc Biol. 2002;71:445-457.
27. van Vliet SJ, van Liempt E, Geijtenbeek TB, et al. Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets. Immunobiology. 2006;211:577-585.
28. van Liempt E, Bank CM, Mehta P, et al. Specificity of DC-SIGN for mannose- and fucose-containing glycans. FEBS Lett. 2006;580:6123-6131.
29. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 2002;23:445-449.
30. van Die I, van Vliet SJ, Nyame AK, et al. The dendritic cellspecific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x. Glycobiology. 2003;13:471-478.
31. Appelmelk BJ, van Die I, van Vliet SJ, et al. Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol. 2003;170:1635-1639.
32. Dell A, Morris HR, Easton RL, et al. Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities. J Biol Chem. 1995;270:24116-24126.
33. Seppala M, Koistinen H, Koistinen R, et al. Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations. Hum Reprod Update. 2007; 13:275-287.
34. van Liempt E, van Vliet SJ, Engering A, et al. Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation. Mol Immunol. 2007; 44:2605-2615.
35. Rieser C, Bock G, Klocker H, et al. Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. J Exp Med. 1997;186:1603-1608.
36. Akbari O, DeKruy RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol. 2001;2:725-731.
37. Hatfield P, Merrick AE, West E, et al. Optimization of dendritic cell loading with tumor cell lysates for cancer immunotherapy. J Immunother. 2008;31:620-632.
38. Mukhopadhyay D, Sundereshan S, Rao C, et al. Placental protein 14 induces apoptosis in T cells but not in monocytes. J Biol Chem. 2001;276:28268-28273.
39. Tee MK, Vigne JL, Yu J, et al. Natural and recombinant human glycodelin activates a proapoptotic gene cascade in monocyte cells. J Leukoc Biol. 2008;83:843-852. Epub 2008 Jan 18.
40. Bachy V, Williams DJ, Ibrahim MA. Altered dendritic cell function in normal pregnancy. J Reprod Immunol. 2008; 78:11-21.
41. Heikkinen J, Mottonen M, Komi J, et al. Phenotypic characterization of human decidual macrophages. Clin Exp Immunol. 2003;131:498-505.
42. Gustafsson C, Hummerdal P, Matthiesen L, et al. Cytokine secretion in decidual mononuclear cells from term human pregnancy with or without labour: ELISPOT detection of IFN-gamma, IL-4, IL-10, TGF-beta and TNF-alpha. J Reprod Immunol. 2006;71:41-56.
43. Vacchio MS, Jiang SP. The fetus and the maternal immune system: pregnancy as a model to study peripheral T-cell tolerance. Crit Rev Immunol. 1999;19:461-480.
44. Sotomayor EM, Borrello I, Rattis FM, et al. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood. 2001; 98:1070-1077.