Vaccination with dendritic cells transfected with mRNA-encoded folate-receptor-α for relapsed metastatic ovarian cancer

Lancet Oncology

Volumn 8, Issue 5, 2007, Pages 451-454

  Hernando, Juan José ^a   Park, Tjoung Won ^a   Fischer, Hans Peter ^a   Zivanovic, Oliver ^a   Braun, Michael ^a   Pölcher, Martin ^a   Grünn, Ursula ^a   Leutner, Claudia ^a   Pötzsch, Bernd ^a   Kuhn, Walther ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CA 125 ANTIGEN; CARBOPLATIN; CD4 ANTIGEN; CD45RA ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; DENDRITIC CELL VACCINE; FOLATE RECEPTOR; FOLATE RECEPTOR ALPHA; MESSENGER RNA; PACLITAXEL; UNCLASSIFIED DRUG;

ADULT; ANTIGEN DETECTION; ARTICLE; AXILLARY LYMPH NODE; CANCER GENE THERAPY; CANCER IMMUNIZATION; CANCER RELAPSE; CANCER STAGING; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOREDUCTIVE SURGERY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; METASTASIS POTENTIAL; MULTIPLE CYCLE TREATMENT; NONVIRAL GENE DELIVERY SYSTEM; OVARY CANCER; PERITONEUM METASTASIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; TREATMENT OUTCOME;

CANCER VACCINES; CARCINOMA, PAPILLARY; CARRIER PROTEINS; CYSTADENOCARCINOMA, SEROUS; DENDRITIC CELLS; FEMALE; FOLIC ACID; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TRANSFECTION; VACCINATION;

EID: 34247218172     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(07)70142-0     Document Type: Article

References (10)

1. Beatty G., and Paterson Y. Regulation of tumor growth by IFN-gamma in cancer immunotherapy. Immunol Res 24 (2001) 201-210
2. Russell J., and Ley T. Lymphocyte-mediated cytotoxicity. Ann Rev Immunol 20 (2002) 323-370
3. Sallusto F., Geginat J., and Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22 (2004) 745-763
4. Kuhn W. Therapy for recurrent ovarian cancer. Curr Womens Health Rep 3 (2003) 33-38
5. Tummala M., and McGuire W. Recurrent ovarian cancer. Clin Adv Hematol Oncol 3 (2005) 723-736
6. Disis M., and Rivkin S. Future directions in the management of ovarian cancer. Hematol Oncol Clin North Am 17 (2003) 1075-1085
7. Kelemen L. The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?. Int J Cancer 119 (2006) 243-250
8. Peoples G., Anderson B., Lee T., et al. Vaccine implications of folate binding protein, a novel cytotoxic T lymphocyte-recognized antigen system in epithelial cancers. Clin Cancer Res 5 (1999) 4214-4223
9. Hernando J., Park T.-W., Kübler K., Offergeld R., Schlebusch H., and Bauknecht T. Vaccination with autologous tumour antigen-pulsed dendritic cells in advanced gynaecological malignancies: clinical and immunological evaluation of a phase I trial. Cancer Immunol Immunother 51 (2002) 45-52
10. Ponsaerts P., Van Tendeloo V., and Berneman Z. Cancer immunotherapy using RNA-loaded dendritic cells. Clin Exp Immunol 134 (2003) 378-384