Pathogenesis of acne vulgaris: Recent advances

Journal of Drugs in Dermatology

Volumn 8, Issue 7, 2009, Pages 615-618

  Bhambri, Sanjay ^a   Del Rosso, James Q ^a   Bhambri, Avani ^b  

^a VALLEY HOSPITAL MEDICAL CENTER   (United States)

^b UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPALENE; ANDROGEN; ANDROSTANOLONE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA DEFENSIN 2; CATHELICIDIN; CD14 ANTIGEN; CHEMOTACTIC FACTOR; CORTICOSTEROID; ESTROGEN; GELATINASE B; GRANULYSIN; HORMONE; HYALURONIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 8; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; POLYPEPTIDE ANTIBIOTIC AGENT; PRASTERONE SULFATE; PROTEINASE; TESTOSTERONE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; BACTERIAL VACCINE; TOLL LIKE RECEPTOR;

ACNE VULGARIS; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BACTERIAL OVERGROWTH; BIOFILM; CLINICAL EVALUATION; COMEDO; CYTOKINE PRODUCTION; DIGITAL IMAGING; ENDOTHELIUM CELL; FOLLICULAR HYPERKERATINIZATION; GENE CONTROL; GENE EXPRESSION; GENOTYPE; HUMAN; INFLAMMATION; INNATE IMMUNITY; KERATINIZATION; KERATINOCYTE; LANGERHANS CELL; MACROPHAGE; MAST CELL; MICROCOMEDO; PATHOGENESIS; PATTERN RECOGNITION; PROPIONIBACTERIUM ACNES; SEBUM SECRETION; SKIN BIOPSY; SKIN EXFOLIATION; T LYMPHOCYTE; TH1 TH2 BALANCE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY;

ACNE VULGARIS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL VACCINES; HORMONES; HUMANS; PROPIONIBACTERIUM ACNES; TOLL-LIKE RECEPTORS;

EID: 67651153128     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Thiboutot DM. Acne. An overview of clinical research findings. Dermatol Clin. 1997;15(1):97-109. (Pubitemid 27034658)
2. Thiboutot DM. Overview of acne and its treatment. Cutis. 2008;81(1 Suppl):3-7.
3. Burkhart CG, Burkhart CN. Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug. J Am Acad Dermatol. 2007;57(4):722-724. (Pubitemid 47384925)
4. Do TT, Zarkhin S, Orringer JS, et al. Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo. J Am Acad Dermatol. 2008;58(4):603-608.
5. Jeremy AH, Holland DB, Roberts SG, et al. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol. 2003;121(1):20-27. (Pubitemid 36900450)
6. Lee DJ, Van Dyke GS, Kim J. Update on pathogenesis and treatment of acne. Curr Opin Pediatr. 2003;15(4):405-410. (Pubitemid 36994055)
7. Coenye T, Peeters E, Nelis HJ. Biofilm formation by Propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors. Res Microbiol. 2007;158(4):386-392. (Pubitemid 46824036)
8. Webster GF, Leyden JJ, Musson RA, et al. Susceptibility of Propionibacterium acnes to killing and degradation by human neutrophils and monocytes in vitro. Infect Immun. 1985;49(1):116-121. (Pubitemid 15062878)
9. Nakatsuji T, Shi Y, Zhu W, et al. Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo. Proteomics. 2008;8(16):3406-3410.
10. Burkhart CN, Burkhart CG. Genome sequence of Propionibacterium acnes reveals immunogenic and surface-associated genes confirming existence of the acne biofilm. Int J Dermatol. 2006;45(7):872. (Pubitemid 43984405)
11. Nakatsuji T, Rasochova L, Huang CM. Vaccine therapy for P. acnes-associated diseases. Infect Disord Drug Targets. 2008;8(3):160-165.
12. Michalak-Stoma A, Tabarkiewicz J, Olender A et al. The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells. Folia Histochem Cytobiol. 2008;46(4):535-539.
13. Miller LS. Toll-like receptos in the skin. Adv Dermatol. 2008;24:71-87.
14. McInturff JE, Kim J. The role of toll-like receptors in the pathophysiology of acne. Semin Cutan Med Surg. 2005;24(2):73-78. (Pubitemid 41111814)
15. McInturff JE, Modlin RL, Kim J. The role of toll-like receptors in the pathogenesis and treatment of dermatological disease. J Invest Dermatol. 2005;125(1):1-8. (Pubitemid 40981417)
16. Harper JC, Thiboutot DM. Pathogenesis of acne: recent research advances. Adv Dermatol. 2003;19:1-10. (Pubitemid 39297508)
17. Wang K, Zane LT. recent advances in acne vulgaris research: insights and clinical implications. Adv Dermatol. 2008;24:197-209.
18. Kim J. Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses. Dermatology. 2005;211(3):193-198. (Pubitemid 41415858)
19. Liu PT, Krutzik SR, Kim J, et al. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function. J Immunol. 200;174(5):2467-2470.
20. Jalian HR, Liu PT, Kanchanapoomi M, et al. All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes. J Invest Dermatol. 2008;128(12):2777- 2778.
21. Jarrousse V, Castex-Rizzi N, Khammari A, et al. Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes. Eur J Dermatol. 2007;17(6):492-496. (Pubitemid 350207159)
22. Tenaud I, Khammari A, Dreno B. In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions. Exp Dermatol. 2007;16(6):500-506. (Pubitemid 46845393)
23. Shibata M, Katsuyama M, Onodera T, et al. Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with Propionibacterium acnes or proinflammatory cytokines. J Invest Dermatol. 2009;129(2):375-382.
24. Nakatsuji T, Liu YT, Huang CP, et al. Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris. PLoS ONE. 20086;3(2):e1551.
25. Nakatsuji T, Liu YT, Huang CP et al. Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: Relevance to therapy for acne vulgaris. J Invest Dermatol. 2008;128(10):2451-2457.
26. Kim J. Acne vaccines: therapeutic option for the treatment of acne vulgaris? J Invest Dermatol. 2008;128(10):2353-2354.
27. Schauber J, Gallo R. Antimicrobial peptides and the skin immune defense system. J Allergy Clin Immunol. 2008;122(2):261-266.
28. McInturff JE, Wang SJ, Machleidt T, et al. Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes. J Invest Dermatol. 2005;125(2):256-263. (Pubitemid 41648158)
29. Nagy I, Pivarcsi A, Koreck A, et al. Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol. 2005;124(5):931-938. (Pubitemid 40629093)
30. Stenger S, Hanson DA, Teitelbaum R, et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998;282(5386):121-125. (Pubitemid 28471143)
31. Nagy I, Pivarcsi A, Kis K, et al. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect. 2006;8(8):2195-2205. (Pubitemid 44335873)
32. Lee DY, Yamasaki K, Rudsil, et al. Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. J Invest Dermatol. 2008;128(7):1863-1866.
33. Zouboulis CC, Schagen S, Alestas T. The sebocyte culture: A model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne. Arch Dermatol Res. 2008;300(8):397-413.
34. Nelson AM, Zhao W, Gilliland K et al. Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells. J Clin Invest. 2008;118(4):1468-1478. (Pubitemid 351500440)
35. George R, Clarke S, Thiboutot D. Hormonal therapy for acne. Semin Cutan Med Surg. 2008;27(3):188-196.
36. Chen W, Thiboutot D, Zouboulis CC. Cutaneous androgen metabolism: basic research and clinical perspectives. J Invest Dermatol. 2002;119(5):992-1007. (Pubitemid 35430476)
37. Thiboutot D. Acne: Hormonal concepts and therapy. Clin Dermatol. 2004;22(5):419-428. (Pubitemid 39535285)
38. Thiboutot DM, Knaggs H, Gilliland K, et al. Activity of type 1 5 alpha-reductase is greater in the follicular infrainfundibulum compared with the epidermis. Br J Dermatol. 1997;136(2):166-171. (Pubitemid 27062713)
39. Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol. 2004;22(5):360-366. (Pubitemid 39535276)
40. Thiboutot D. Regulation of human sebaceous glands. J Invest Dermatol. 2004;123(1):1-12. (Pubitemid 38833457)
41. Chen W, Thiboutot D, Zouboulis CC. Cutaneous androgen metabolism: Basic research and clinical perspectives. J Invest Dermatol. 2002;119(5):992-1007. (Pubitemid 35430476)
42. Rosenfield RL, Deplewski D. Role of androgens in the developmental biology of the pilosebaceous unit. Am J Med. 1995;98(1A):80S-88S.
43. Thiboutot D. Hormones and acne: Pathophysiology, clinical evaluation, and therapies. Semin Cutan Med Surg. 2001;20(3):144-153. (Pubitemid 32927776)
44. Thiboutot D, Chen W. Update and future of hormonal therapy in acne. Dermatology. 2003;206(1):57-67. (Pubitemid 36164667)
45. Slominski A, Ermak G, Hwang J, et al. Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin. FEBS Lett. 1995;374(1):113-116.
46. Zouboulis CC, Seltmann H, Hiroi N, et al. Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A. 2002;99(10):7148-7153. (Pubitemid 34526270)
47. Ganceviciene R, Graziene V, Fimmel S, et al. Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. Br J Dermatol. 2008;160(2):345-352.