Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo

Journal of the American Academy of Dermatology

Volumn 58, Issue 4, 2008, Pages 603-608

  Do, Thy Thy ^a   Zarkhin, Semyon ^a   Orringer, Jeffrey S ^a   Nemeth, Shari ^a   Hamilton, Ted ^a   Sachs, Dana ^a   Voorhees, John J ^a   Kang, Sewon ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACNE; ARTICLE; CLINICAL ARTICLE; COMEDO; COMPUTER ANALYSIS; COMPUTER PROGRAM; FEMALE; HUMAN; INFLAMMATION; MALE; PRIORITY JOURNAL; PUSTULE; SCAR; SKIN NODULE;

ACNE VULGARIS; ADOLESCENT; ADULT; DIAGNOSIS, COMPUTER-ASSISTED; FACE; FACIAL DERMATOSES; FEMALE; HUMANS; INFLAMMATION; MALE; PHOTOGRAPHY;

EID: 40649121682     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2007.12.024     Document Type: Article

References (26)

1. White G.M. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol 39 (1998) 34-37
2. Goulden V., Stables G.I., and Cunliffe W.J. Prevalence of facial acne in adults. J Am Acad Dermatol 41 (1999) 577-580
3. Pochi P.E., Shalita A.R., Strauss J.S., Webster S.B., Cunliffe W.J., Katz H.I., et al. Report of the Consensus Conference on Acne Classification, Washington, D.C., March 24 and 25, 1990. J Am Acad Dermatol 24 (1991) 495-500
4. Brown S.K., and Shalita A.R. Acne vulgaris. Lancet 351 (1998) 1871-1876
5. Cook C.H., Centner R.L., and Michaels S.E. An acne grading method using photographic standards. Arch Dermatol 115 (1979) 571-575
6. Cunliffe W.J., Holland D.B., and Jeremy A. Comedone formation: etiology, clinical presentation, and treatment. Clin Dermatol 22 (2004) 367-374
7. O'Brien S., Lewis J., and Cunliffe W. The Leeds revised acne grading system. J Dermatol Treat 9 (1998) 215-220
8. Witkowski J.A., and Parish L.C. The assessment of acne: an evaluation of grading and lesion counting in the measurement of acne. Clin Dermatol 22 (2004) 394-397
9. Doshi A., Zaheer A., and Stiller M.J. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 36 (1997) 416-418
10. Strauss J.S., Krowchuk D.P., Leyden J.J., Lucky A.W., Shalita A.R., Siegfried E.C., et al. Guidelines of care for acne vulgaris management. J Am Acad Dermatol 56 (2007) 651-663
11. Orringer J.S., Kang S., Hamilton T., Schumacher W., Cho S., Hammerberg C., et al. Treatment of acne vulgaris with a pulsed dye laser. JAMA 291 (2004) 2834-2839
12. Lodriguss J. Catching the light: aligning images in Picture Window. Available at: http://www.astropix.com/HTML/J_DIGIT/PWALIGN.HTM. Accessed May 3, 2007.
13. Zaenglein A.L., and Thiboutot D.M. Acne vulgaris. In: Bolognia J.L., Jorizzo J.L., and Rapini R.P. (Eds). Dermatology (2004), Mosby, Philadelphia 533-534
14. Knaggs H.E., Holland D.B., Morris C., Wood E.J., and Cunliffe W.J. Quantification of cellular proliferation in acne using the monoclonal antibody Ki67. J Invest Dermatol 102 (1994) 89-92
15. Hughes B.R., Morris C., Cunliffe W.J., and Leigh I.M. Keratin expression in pilosebaceous epithelia in truncal skin of acne patients. Br J Dermatol 134 (1996) 247-256
16. Orentreich N., and Durr N.P. The natural evolution of comedones into inflammatory papules and pustules. J Invest Dermatol 62 (1974) 316-320
17. Rizova E., and Kligman A. New photographic techniques for clinical evaluation of acne. J Eur Acad Dermatol Venereol 15 (2001) 113-118
18. Leyden J.J., McGinley K.J., Mills O.H., and Kligman A.M. Propionibacterium levels in patients with and without acne vulgaris. J Invest Dermatol 65 (1975) 382-384
19. Kim J., Ochoa M.T., Krutzik S.R., Takeuchi O., Uematsu S., and Legaspi A.J. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 169 (2002) 1535-1541
20. Downing D.T., Stewart M.E., Wertz P.W., and Strauss J.S. Essential fatty acids and acne. J Am Acad Dermatol 14 (1986) 221-225
21. Ingham E., Eady E.A., Goodwin C.E., Cove J.H., and Cunliffe W.J. Pro-inflammatory levels of interleukin-1 alpha-like bioactivity are present in the majority of open comedones in acne vulgaris. J Invest Dermatol 98 (1992) 895-901
22. Webster G.F. Inflammation in acne vulgaris. J Am Acad Dermatol 33 (1995) 247-253
23. Kang S., Cho S., Chung J.H., Hammerberg C., Fisher G.J., and Voorhees J.J. Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo. Am J Pathol 166 (2005) 1691-1699
24. Jeremy A.H., Holland D.B., Roberts S.G., Thomson K.F., and Cunliffe W.J. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 121 (2003) 20-27
25. Nakano K., Kiyokane K., Benvenuto-Andrade C., and Gonzalez S. Real-time reflectance confocal microscopy, a non-invasive tool for in vivo quantitative evaluation of comedolysis in the rhino mouse model. Skin Pharmacol Physiol 20 (2007) 29-36
26. Aldana O.L., Holland D.B., and Cunliffe W.J. Variation in pilosebaceous duct keratinocyte proliferation in acne patients. Dermatology 196 (1998) 98-99