Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against propionibacterium acnes

Journal of Investigative Dermatology

Volumn 125, Issue 2, 2005, Pages 256-263

  McInturff, Jamie E ^a   Wang, Shyh Jeun ^a   Machleidt, Thomas ^b   Lin, T Richard ^b,h   Oren, Ami ^a,c   Hertz, Cheryl J ^a   Krutzik, Stephan R ^a   Hart, Scott ^b   Zeh, Karin ^b   Anderson, Daniel H ^d,e   Gallo, Richard L ^f,g   Modlin, Robert L ^a   Kim, Jenny ^a,i  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Ansata Therapeutics   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^h Explora BioLabs   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acne; Antimicrobial peptide; Inflammation; Innate immunity; Skin

Indexed keywords

GRANULYSIN; HELIX LOOP HELIX PROTEIN; PROTEINASE; SYNTHETIC PEPTIDE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CYTOKINE; GNLY PROTEIN, HUMAN; PEPTIDE FRAGMENT; T LYMPHOCYTE ANTIGEN;

ACNE; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON MICROSCOPY; IN VITRO STUDY; INNATE IMMUNITY; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; ACNE VULGARIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MONOCYTE;

ACNE VULGARIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CYTOKINES; HELIX-LOOP-HELIX MOTIFS; HUMANS; MONOCYTES; PEPTIDE FRAGMENTS; PROPIONIBACTERIUM ACNES;

EID: 24344449113     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23805.x     Document Type: Article

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