Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5526-5534

  Malviya, Manish ^a   Sunil Kumar, Y C ^a   Mythri, R B ^b   Venkateshappa, C ^b   Subhash, M N ^b   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Dementia; Muscarinic agonist

Indexed keywords

[2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)MORPHOLINO](4 TOLYL)METHANONE; ARECOLINE; MUSCARINIC M1 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; PRESENILE DEMENTIA; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ARECOLINE; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; MALE; MAZE LEARNING; MEMORY DISORDERS; MORPHOLINES; MUSCARINIC AGONISTS; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M1; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RATTUS;

EID: 67651115824     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.032     Document Type: Article

References (45)

1. Selkoe D.J. Physiol. Rev. 81 (2001) 741
2. Coyle J.T., Price D.L., and DeLong M.R. Science 219 (1983) 1184
3. Palmer A.M. Trends Pharmacol. Sci. 23 (2002) 426
4. Anagnostaras S.G., Murphy G.G., Hamilton S.E., Mitchell S.L., Rahnama N.P., Nathanson N.M., and Silva A.J. Nat. Neurosci. 6 (2003) 51
5. Levey A.I. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 13541
6. Eglen R.M., Choppin A., and Watson N. Trends Pharmacol. Sci. 22 (2001) 409
7. Fisher A. Jpn. J. Pharmacol. 84 (2000) 101
8. Lin L., Georgievska B., Mattsson A., and Isacson O. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 12108
9. De Sarno P., Shestopal S.A., King T.D., Zmijewska A., Song L., and Jope R.S. J. Biol. Chem. 278 (2003) 11086
10. Leloup C., Michaelson D.M., Fisher A., Hartmann T., Beyreuther K., and Stein R. Cell Death Differ. 7 (2000) 825
11. Selkoe D.J. J. Neuropathol. Exp. Neurol. 53 (1994) 438
12. Gabuzda D., Busciglio J., and Yankner B.A. J. Neurochem. 61 (1993) 2326
13. Buxbaum J.D., Oishi M., Chen H.I., Pinkas-Kramarski R., Jaffe E.A., Gandy S.E., and Greengard P. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 10075
14. Haring R., Fisher A., Marciano D., Pittel Z., Kloog Y., Zuckerman A., Eshhar N., and Heldman E. J. Neurochem. 71 (1998) 2094
15. Nitsch R.M., Slack B.E., Wurtman R.J., and Growdon J.H. Science 258 (1992) 304
16. Genis I., Fisher A., and Michaelson D.M. J. Neurochem. 72 (1999) 206
17. Sadot E., Gurwitz D., Barg J., Behar L., Ginzburg I., and Fisher A. J. Neurochem. 66 (1996) 877
18. Gu Z., Zhong P., and Yan Z. J. Biol. Chem. 278 (2003) 17546
19. Ma X.H., Zhong P., Gu Z., Feng J., and Yan Z. J. Neurosci. 23 (2003) 1159
20. Christie J.E., Shering A., Ferguson J., and Glen A.I. Br. J. Psychiat. 138 (1981) 46
21. Sauerberg P., Olesen P.H., Nielsen S., Treppendahl S., Sheardown M.J., Honore T., Mitch C.H., Ward J.S., Pike A.J., Bymaster F.P., et al. J. Med. Chem. 35 (1992) 2274
22. Sauerberg P., Kindtler J.W., Nielsen L., Sheardown M.J., and Honore T. J. Med. Chem. 34 (1991) 687
23. Chandra J.N., Malviya M., Sadashiva C.T., Subhash M.N., and Rangappa K.S. Neurochem. Int. 52 (2008) 376
24. Kumar S.Y.C., Sadashiva M.P., and Rangappa K.S. Tetrahedron Lett. 48 (2007) 4565
25. Malviya M., Kumar Y.C., Asha D., Chandra J.N., Subhash M.N., and Rangappa K.S. Bioorg. Med. Chem. 16 (2008) 7095
26. Emmerling M.R., Moore C.J., Doyle P.D., Carroll R.T., and Davis R.E. Biochem. Biophys. Res. Commun. 197 (1993) 292
27. Haring R., Gurwitz D., Barg J., Pinkas-Kramarski R., Heldman E., Pittel Z., Wengier A., Meshulam H., Marciano D., Karton Y., et al. Biochem. Biophys. Res. Commun. 203 (1994) 652
28. Buxbaum J.D., Ruefli A.A., Parker C.A., Cypess A.M., and Greengard P. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 4489
29. Hulme E.C., Birdsall N.J., and Buckley N.J. Annu. Rev. Pharmacol. Toxicol. 30 (1990) 633
30. Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J., and Capon D.J. EMBO J. 6 (1987) 3923
31. Levey A.I., Kitt C.A., Simonds W.F., Price D.L., and Brann M.R. J. Neurosci. 11 (1991) 3218
32. Wei J., Walton E.A., Milici A., and Buccafusco J.J. J. Neurochem. 63 (1994) 815
33. Farber S.A., Nitsch R.M., Schulz J.G., and Wurtman R.J. J. Neurosci. 15 (1995) 7442
34. Creese I., and Snyder S.H. Eur. J. Pharmacol. 49 (1978) 201
35. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. J. Biol. Chem. 193 (1951) 265
36. Hyttel J., Nielsen J.B., and Nowak G.J. Neural. Transm. Gen. Sect. 89 (1992) 61
37. Yamamura H.I., and Snyder S.H. Proc. Natl. Acad. Sci. U.S.A. 71 (1974) 1725
38. McPherson G.A. Comput. Progr. Biomed. 17 (1983) 107
39. Kendall D.A., and Nahorski S.R. J. Pharmacol. Exp. Ther. 233 (1985) 473
40. Van Rooijen L.A., Seguin E.B., and Agranoff B.W. Biochem. Biophys. Res. Commun. 112 (1983) 919
41. Gonzales R.A., and Crews F.T. J. Neurosci. 4 (1984) 3120
42. Sharma A.C., and Kulkarni S.K. Methods Find Exp. Clin. Pharmacol. 12 (1990) 175
43. Sharma A.C., and Kulkarni S.K. Methods Find Exp. Clin. Pharmacol. 13 (1991) 155
44. Itoh J., Nabeshima T., and Kameyama T. Psychopharmacology 101 (1990) 27
45. Sharma A.C., and Kulkarni S.K. Progr. Neuro-Psychopharmacol. Biol. Psychiat. 16 (1992) 117