An efficient synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine: a potent M1 selective muscarinic agonist

Tetrahedron Letters

Volumn 48, Issue 26, 2007, Pages 4565-4568

  Sunil Kumar, Y C ^a   Sadashiva, M P ^a   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

2 Acetyl pyridine; Arecoline; C Substituted morpholines

Indexed keywords

2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; ANTIINFECTIVE AGENT; ARECOLINE; MORPHOLINE DERIVATIVE; MUSCARINIC M1 RECEPTOR AGONIST; PHENDIMETRAZINE; POLYGONAPHOLINE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANTIMICROBIAL ACTIVITY; ARTICLE; BROMINATION; CYCLIZATION; DEHYDRATION; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; REACTION ANALYSIS;

EID: 34249330905     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.04.135     Document Type: Article

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15. +).
16. 2O: Calcd C, 75.56; H, 7.13; N, 11.0%. Found C, 75.60; H, 7.10; N, 11.23%.
17. 3, 300 MHz): δ 9.37 (d, J = 6.0 Hz, 1H), 9.08 (s, 1H), 8.41 (d, J = 7.8 Hz, 1H), 8.13-8.17 (t, J = 6.9 Hz, 1H), 4.64-4.75 (br m, 4H), 4.2-4.2 (d, J = 12.9 Hz, 1H), 4.03-4.07 (d, J = 11.4 Hz 1H), 3.96 (br m, 1H), 3.67-3.75 (t, J = 11.85 Hz, 1H), 3.09 (br m, 1H), 2.91-2.99 (t, J = 11.85 Hz, 1H), 1.43 (s, 9H).
18. 3: Calcd C, 63.8; H, 9.28; N, 9.92%. Found C, 63.82; H, 9.30; N, 9.89%.
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