Muscarinic receptor 1 agonist activity of novel N-arylthioureas substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7095-7101

  Malviya, Manish ^a   Kumar, Y C Sunil ^a   Asha, D ^a   Chandra, J N Narendra Sharath ^a   Subhash, M N ^b   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Agonist; Alzheimer's disease; Dementia; Displacement assay; In vitro; In vivo; Inositol (1,4,5) trisphosphate; M1 receptor; Rat brain

Indexed keywords

2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL) N (2 METHOXYPHENYL)MORPHOLINE 4 CARBOTHIOAMIDE; 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL) N (3 METHOXYPHENYL)MORPHOLINE 4 CARBOTHIOAMIDE; 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL) N (4 METHOXYPHENYL)MORPHOLINE 4 CARBOTHIOAMIDE; 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)N PHENYLMORPHOLINE 4 CARBOTHIOAMIDE; ALCOHOL; ALPHA BROMO ACETYL PYRIDINE; MORPHOLINE DERIVATIVE; MUSCARINIC AGENT; N (2 CHLOROPHENYL) 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)MORPHOLINE 4 CARBOTHIOAMIDE; N (2 FLUOROPHENYL) 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)MORPHOLINE 4 CARBOTHIOAMIDE; N (2,4 DICHLOROPHENYL) 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)MORPHOLINE 4 CARBOTHIOAMIDE; N (3 CHLOROPHENYL) 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)MORPHOLINE 4 CARBOTHIOAMIDE; N (4 CHLOROPHENYL) 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)MORPHOLINE 4 CARBOTHIOAMIDE; N (4 FLUOROPHENYL) 2 (1,2,5,6 TETRAHYDRO 1 METHYLPYRIDIN 3 YL)MORPHOLINE 4 CARBOTHIOAMIDE; N BENZYL AMINO ETHANOL; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; LEARNING; MALE; MAZE TEST; MEMORY; NONHUMAN; RAT; RECEPTOR AFFINITY;

ALZHEIMER DISEASE; AMNESIA; ANIMALS; ARECOLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; INOSITOL 1,4,5-TRISPHOSPHATE; LEARNING; MALE; MOLECULAR STRUCTURE; MUSCARINIC ANTAGONISTS; RATS; RECEPTOR, MUSCARINIC M1; SCOPOLAMINE; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 48449093351     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.053     Document Type: Article

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