Efficient synthesis of 2-substituted pyrido[3,2-d]pyrimidines involving SNAr and palladium-catalyzed cross-coupling reactions

Synthesis

Volumn , Issue 14, 2009, Pages 2379-2384

  Tikad, Abdellatif ^a,b   Routier, Sylvain ^a   Akssira, Mohamed ^b   Léger, Jean Michel ^c   Jarry, Christian ^c   Guillaumet, Gérald ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b HASSAN II UNIVERSITY   (Morocco)

^c Laboratoire de Pharmacochimie   (France)

Author keywords

Amination; Arylations; Palladium

Indexed keywords

ARYLATIONS; EFFICIENT SYNTHESIS; FUNCTIONALIZED; GOOD YIELD; PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS; REGIO-SELECTIVE;

AMINATION; AMINES; COMPLEXATION; SYNTHESIS (CHEMICAL);

PALLADIUM;

2 (2 CHLOROPHENYLAMINO)PYRIDO(3,2 DEXTRO)PYRAMIDINE; 2 (2 FURYL)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (2 THIENYL)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (4 CHLOROPHENYLAMINO)PYRIDO(3,2 DEXTRO)PYRAMIDINE; 2 (4 METHOXYBENZYLAMINO)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (4 METHOXYPHENYLAMINO)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (ACYLAMINO)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (ALKYLAMINO)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (ARYLAMINO)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (BUTYLAMINO)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 (PHENYLAMINO)PYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 HETEARYLPYRIDO(3,2 DEXTRO)PYRIMIDINE; 2 PHENYL(3,2 DEXTRO)PYRIMIDINE; 2 PHENYLPYRIDO(3,2 DEXTRO)PYRIMIDINE; 4 CHLORO N[PYRIDO(3,2 DEXTRO)PYRIMIDIN 2 YL]BENZAMIDE; ETHYL N[PYRIDO(3,2 DEXTRO)PYRIMIDIN 2 YL]CARBAMATE; N [PYRIDO(3,2 DEXTRO)PYRIMIDIN 2 YL]BENZAMIDE; N[PYRIDO(3,2 DEXTRO)PYRIMIDIN 2 YL]ACETAMIDE; N[PYRIDO(3,2 DEXTRO)PYRIMIDIN 2 YL]CARBAMATE; N[PYRIDO(3,2 DEXTRO)PYRIMIDIN 2 YL]NICOTINAMIDE; PALLADIUM; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMIDATION; AMINATION; ARTICLE; ARYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL REACTION; DECHLORINATION; DRUG DETERMINATION; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; STEREOCHEMISTRY; SUBSTITUTION REACTION;

EID: 67651113409     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0029-1216854     Document Type: Article

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