Identification of new Hsp90 inhibitors by structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4839-4842

  Hong, Tae Joon ^a   Park, Hwangseo ^b   Kim, Yun Jung ^a   Jeong, Jae Hoon ^c   Hahn, Ji Sook ^a  

^a Seoul National University   (South Korea)

^b Sejong University   (South Korea)

^c Inha University   (South Korea)

Author keywords

4H 1,2,4 triazole 3 thiol; Anti cancer drug; Hsp90 inhibitors; Pyrimidine 2,4,6 trione; Virtual screening

Indexed keywords

3 PHENYL 2 STYRYL 3H QUINAZOLIN 4 ONE; 4H 1,2,4 TRIAZOLE 3 THIOL DERIVATIVE; ADENOSINE TRIPHOSPHATASE INHIBITOR; BETA TUBULIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; PYRIMIDINE; PYRIMIDINE 2,4,6 TRIONE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPUTER ANALYSIS; COMPUTER PROGRAM; CONTROLLED STUDY; ENZYME INHIBITION; IC 50; MOLECULAR DYNAMICS; NONHUMAN; SIMULATION; STRUCTURE BASED VIRTUAL SCREENING; VIRTUAL REALITY;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DATABASES, FACTUAL; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PYRIMIDINES; RECEPTOR, ERBB-2; TRIAZOLES;

EID: 67651108949     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.040     Document Type: Article

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