Dual role of shikonin in early and late stages of collagen type II arthritis

Molecular Biology Reports

Volumn 36, Issue 6, 2009, Pages 1597-1604

  Dai, Qiaomei ^a   Fang, Jianghong ^b   Zhang, Feng Shan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Shikonin; Th1; Th2

Indexed keywords

BETA ACTIN; COLLAGEN TYPE 2; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; SHIKONIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKLE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTICULAR CARTILAGE; BONE EROSION; CARTILAGE DEGENERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; ERYTHEMA; HISTOPATHOLOGY; IMMUNOMODULATION; INFLAMMATORY CELL; KNEE; MALE; MOUSE; NONHUMAN; PATELLA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SWELLING; SYNOVIUM; TH1 CELL; TH2 CELL; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; CYTOKINES; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; INTERLEUKINS; KNEE JOINT; MICE; NAPHTHOQUINONES; RNA, MESSENGER; SYNOVIAL MEMBRANE; TREATMENT OUTCOME;

MURINAE; MUS;

EID: 67651108898     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-008-9356-7     Document Type: Article

References (28)

1. MJ Vervoordeldonk PP Tak 2002 Cytokines in rheumatoid arthritis Curr Rheumatol Rep 4 3 208 217 10.1007/s11926-002-0067-0
2. L Mendoza 2006 A network model for the control of the differentiation process in Th cells Biosystems 84 2 101 114 10.1016/j.biosystems.2005.10.004 (Pubitemid 43670489)
3. Y Okamoto M Nishida 2001 Cytokine balance in the pathogenesis of rheumatoid arthritis Yakugaku Zasshi 121 2 131 138 10.1248/yakushi.121.131 (Pubitemid 32127249)
4. KW Moore A O'Garra 1993 Interleukin-10 Annu Rev Immunol 11 165 190
5. J Rengarajan SJ Szabo 2000 Transcriptional regulation of Th1/Th2 polarization Immunol Today 21 479 483 10.1016/S0167-5699(00)01712-6 (Pubitemid 30782209)
6. HD Chang C Helbig 2007 Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3 Eur J Immunol 37 3 807 817 10.1002/eji.200636385 (Pubitemid 46916947)
7. SJ Szabo ST Kim 2000 A novel transcription factor, T-bet, directs Th1 lineage commitment Cell 100 655 669 10.1016/S0092-8674(00)80702-3
8. J Sun EJ Pearce 2007 Suppression of early IL-4 production underlies the failure of CD4 + T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells J Immunol 178 3 1635 1644
9. D Agnello CS Lankford 2003 Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights J Clin Immunol 23 3 147 161 10.1023/A:1023381027062 (Pubitemid 36522792)
10. DD Brand KA Latham 2007 Collagen-induced arthritis Nat Protoc 2 5 1269 1275 10.1038/nprot.2007.173 (Pubitemid 46901304)
11. A Pietrosiuk E Skopińska-Rózewska 2004 Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice Pharmazie 59 8 640 642
12. X Chen L Yang 2003 Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1 Antimicrob Agents Chemother 9 47 2810 2816
13. B Singh MK Sharma 2003 Anti-inflammatory activity of shikonin derivatives from Arnebia hispidissima Phytomedicine 10 5 375 380 10.1078/0944-7113-00262 (Pubitemid 36745159)
14. P Bernard B Leung 2004 Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis Clin Exp Immunol 136 440 447 10.1111/j.1365-2249.2004.02430.x (Pubitemid 38703677)
15. Y Yamaguchi K Fujio 2007 IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis J Immunol 179 10 7128 7136
16. K Nirmal M Damian 2003 Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein J Immunol 171 2109 2115
17. RL Smeets FAJ van de Loo 2003 Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice Gene Ther 10 1004 1011 10.1038/sj.gt.3301986 (Pubitemid 36722490)
18. B Gao D Fang 2006 The pro-inflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway Arthritis Res Ther 172 1186 2011
19. J Dulos E Verbraak 2004 Severity of murine collagen-induced arthritis correlates with increased CYP7B activity Arthritis Rheum 50 10 3346 3353 10.1002/art.20509 (Pubitemid 39372013)
20. A Kristine L Kuhn 2006 Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis J Clin Invest 116 961 973 10.1172/JCI25422
21. V Staniforth S-Y Wang 2004 Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor α promoter in vivo J Biol Chem 7 279 5877 5885
22. X Chen J Oppenheim 2001 Shikonin, a component of anti-inflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1 Int Immunopharmacol 1 2 229 236 10.1016/S1567-5769(00)00033-3 (Pubitemid 32183722)
23. T Ishida I Sakaguchi 2007 Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon Biol Pharm Bull 30 5 928 934 10.1248/bpb.30.928 (Pubitemid 46708642)
24. HSU Yu-Hsiang LI Hsing-Hui 2006 Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis Arthritis Rheum 54 9 2722 2733 10.1002/art.22039 (Pubitemid 44497751)
25. Y Kageyama Y Koide 2004 Plasmid encoding interleukin-4 in the amelioration of murine collagen-induced arthritis Arthritis Rheum 50 3 968 975 10.1002/art.20107 (Pubitemid 38326198)
26. KM Murphy SL Reiner 2002 The lineage decisions of helper T cells Nat Rev Immunol 2 933 944 10.1038/nri954 (Pubitemid 37323214)
27. SJ Szabo BM Sullivan 2003 Molecular mechanisms regulating Th1 immune responses Annu Rev Immunol 21 713 758 10.1146/annurev.immunol.21.120601.140942 (Pubitemid 37174546)
28. Chakir H, Wang H et al (2003) T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations. predominant role of GATA-3. J Immunol Methods 278:157-169. doi: 10.1016/S0022-1759(03)00200-X (Pubitemid 37281199)