Role of phosphoinositide 3-kinase in ischemic postconditioning-induced attenuation of cerebral ischemia-evoked behavioral deficits in mice

Pharmacological Reports

Volumn 59, Issue 2, 2007, Pages 192-198

  Rehni, Ashish K ^a   Singh, Nirmal ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

Cerebral ischemia; Ischemic postconditioning; Phosphoinositide 3 kinase; Wortmannin

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN ISCHEMIA; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; ENZYME ACTIVATION; LATENT PERIOD; MALE; MAZE TEST; MEMORY DISORDER; MOTOR COORDINATION; MOUSE; NONHUMAN; REPERFUSION; SHORT TERM MEMORY; TIME; WALKING;

EID: 34250779384     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Alonsode de Lecinana M, Diez-Tejedor E, Cearcellar F, Roda JM: Cerebral ischemia from animal studies to clinical practice. Should the methods be reviewed? Cerebrovasc Dis, 2001, 11, Supp 1, 20-30.
2. Arcaro A, Wymann MP: Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J, 1993, 296, 297-301.
3. Baker K, Markus CB, Huffman K, Kruk H, Malfory B, Doctrow SR: Synthetic combined superoxide dismutase catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther, 1998, 284, 215-221.
4. Bazan NG: Neuroprotective signaling in neurodegeneration and neurorepair. Pharmacol Rep, 2005, 57, 405-411.
5. Bederson JB, Pitts LH, Tsuji M, Nishimur MC, Davis RL, Bartowski H: Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke, 1986, 17, 472-476.
6. Burda J, Danielisova V, Nemethova M, Goutlieb M, Matiasova M, Domorakova I, Mechirova E et al.: Delayed postconditioning initiates additive mechanism necessary for survival of selectively vulnerable neurons after transient ischemia in rat brain. Cell Mol Neurobiol, 2006, 26, 1139.
7. Chiari PC, Bienengraeber MW, Pagel PS, Krolikowski JG, Kersten JR, Warltier DC: Isoflurane protects against myocardial infarction during early reperfusion by activation on phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits. Anesthesiology, 2005, 102, 102-109.
8. Danielisova V, Nemethova M, Gottlieb M, Burda J: The changes in endogenous antioxidant enzyme activity after postconditioning. Cell Mol Neurobiol, 2006, 26, 1179.
9. Dobkin BH: The rehabilitation of elderly stroke patients. Clin Geriat Med, 1991, 7, 507-523.
10. Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG: Responses to cortical injury: I. Methodology and local effects of concusions in the rat. Brain Res, 1981, 211, 67-77.
11. Gupta R, Singh M, Sharma A: Neuroprotective effect of antioxidants on ischaemia reperfusion-induced cerebral injury. Pharmacol Res, 2003, 48, 209-215.
12. Himori N, Wantanabe H, Akaike N, Kurasawa M, Itoh J, Tanaka Y: Cerebral ischemia model with conscious mice. Involvement of NMDA receptor activation and derangement of learning and memory ability. J Pharmacol Methods, 1990, 23, 311-327.
13. Itoh J, Nabeshima T, Kameyama T: Utility of an elevated plus maze for the valuation of memory in mice. Effects of nootropics, scopolamine and electroconvulsive shock. Psychopharmacology, 1990, 101, 27-32.
14. Jenkins LW, Povlishock JT, Lewelt W, Miller JD, Becker DP: The role of postischemic recirculation in the development of ischemic neuronal injury following complete cerebral ischemia. Acta Neuropathol, 1981, 5, 205-220.
15. Kin H, Zatta AJ, Lofye MT, Amerson BS, Halkos ME, Keredi F, Zhao ZQ et al.: Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine. Cardiovas Res, 2005, 67, 124-133.
16. Kin H, Zhao ZQ, Sun HY, Wang NP, Corvera JS, Halkos ME, Keredi F et al.: Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res, 2004, 62, 74-85.
17. Kitagawa K, Matsumoto M, Tagaya M, Hata R, Ueda H, Niinobe M, Handa N et al.: "Ischemic tolerance" phenomenon found in brain. Brain Res, 1990, 528, 21-24.
18. Murray CE, Jennings RB, Reimer KA: Preconditioning with ischemia: a delay of lethal cell injury in ischemic cell injury in ischemic myocardium. Circulation, 1986, 74, 1124-1136.
19. Peng LY, Ma H, He JG, Gao XR, Zhang Y, He XH, Zhai YS, Zhang XJ: Ischemic postconditioning attenuates ischemia reperfusion injury in isolated hypertrophied rat heart. Zhonghua Xin Xue Guan Bing Za Zhi, 2006, 34, 685-689.
20. Ruscher K, Freyer D, Karch M, Isaev N, Megow D, Sawitzki B, Priller J et al.: Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J. Neurosci, 2002, 22, 10291-10301.
21. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit J-F et al.: Postconditioning the human heart. Circulation, 2005, 112, 2143-2148.
22. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM: Postconditioning: a form of modified reperfusion protects the myocardium by activating the phosphatidynolisitol 3-kinase-Akt pathway, Circ Res, 2004, 95, 230-232.
23. Whisnant JH: The decline of stroke. Stroke, 1984, 15, 160-168.
24. White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI et al.: Brain ischemia and reperfusion: molecular mechanism of neuronal injury. J Neurol Sci, 2000, 179, 1-33.
25. Zdenek H, Ivan K: Concurrent administration of subeffective doses of scopolamine and MK-801 produces a short-term amnesia for the elevated plus-maze in mice. Behav Brain Res, 1998, 91, 83-89.
26. Zhao H, Sapolsky RM, Steinberg GK: Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J Cerebr Blood Flow Metab, 2006, 26, 1114-1121.
27. Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Johansen JV: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol, 2003, 285, H579-H588.