Immunohistochemical analyses of β-catenin and cyclin D1 expression in giant cell tumor of bone (GCTB): A possible role of Wnt pathway in GCTB tumorigenesis

Pathology Research and Practice

Volumn 205, Issue 9, 2009, Pages 626-633

  Matsubayashi, Shohei ^a   Nakashima, Masahiro ^b   Kumagai, Kenji ^a   Egashira, Masayuki ^a   Naruke, Yuki ^a   Kondo, Hisayoshi ^b   Hayashi, Tomayoshi ^c   Shindo, Hiroyuki ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c NAGASAKI UNIVERSITY HOSPITAL   (Japan)

Author keywords

catenin; Cyclin D1; Giant cell tumor of bone; Wnt pathway

Indexed keywords

ALCOHOL; BETA CATENIN; CYCLIN D1; KI 67 ANTIGEN; POLY(METHYL METHACRYLATE); WNT PROTEIN;

ADULT; ARTICLE; BONE GRAFT; BONE RESECTION; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GIANT CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LABELING INDEX; MALE; MONONUCLEAR CELL; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOMA; OSTEOLYSIS; PATHOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR LOCALIZATION; TUMOR RECURRENCE;

ADOLESCENT; ADULT; BETA CATENIN; BONE NEOPLASMS; CELL NUCLEUS; CYCLIN D1; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GIANT CELL TUMOR OF BONE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; SIGNAL TRANSDUCTION; WNT PROTEINS; YOUNG ADULT;

EID: 67651098954     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.02.011     Document Type: Article

References (28)

1. Huang L., Teng X.Y., Cheng Y.Y., Lee K.M., and Kumta S.M. Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of bone. Bone 34 (2004) 393-401
2. Kandel R., Li S.Q., Bell R., Wunder J., Ferguson P., Kauzman A., Diehl J.A., and Werier J. Cyclin D1 and p21 is elevated in the giant cells of giant cell tumors. J. Orthop. Res. 24 (2006) 428-437
3. Kauzman A., Li S.Q., Bradley G., Bell R.S., Wunder J.S., and Kandel R. Cyclin alterations in giant cell tumor of bone. Mod. Pathol. 16 (2003) 210-218
4. Ishigaki K., Namba H., Nakashima M., Nakayama T., Mitsutake N., Hayashi T., Maeda S., Ichinose M., Kanematsu T., and Yamashita S. Aberrant localization of β-catenin correlates with overexpression of its target gene in human papillary thyroid cancer. J. Clin. Endocrinol. Metab. 87 (2002) 3433-3440
5. Meirmanov S., Nakashima M., Kondo H., Matsufuji R., Takamura N., Ishigaki K., Ito M., Prouglo Y., Yamashita S., and Sekine I. Correlation of cytoplasmic β-catenin and cyclin D1 overexpression during thyroid carcinogenesis around Semipalatinsk Nuclear Test Site. Thyroid 13 (2003) 537-545
6. Nakashima M., Meirmanov S., Naruke Y., Kondo H., Saenko V., Rogounovitch T., Shimizu-Yoshida Y., Takamura N., Namba H., Ito M., Abrosimov A., Lushnikov E., Roumiantsev P., Tsyb A., Yamashita S., and Sekine I. Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant β-catenin expression. J. Pathol. 202 (2004) 446-455
7. Cadigan K.M., and Nusse R. Wnt signaling: a common theme in animal development. Genes Dev. 11 (1997) 3296-3305
8. Rubinfeld B., Robbins P., El-Gamil M., Albert I., Porfiri E., and Polakis P. Stabilization of β-catenin by genetic defects in melanoma cell lines. Science 275 (1997) 1790-1792
9. Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., and Kinzler K.W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275 (1997) 1787-1790
10. Korinek V., Barker N., Morin P.J., van Wichen D., de Weger R., Kinzler K.W., Vogelstein B., and Clevers H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma. Science 275 (1997) 1784-1787
11. Kawanishi J., Kato J., Sasaki K., Fujii S., Watanabe N., and Niitsu Y. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line, HSC-39. Mol. Cell. Biol. 15 (1995) 1175-1181
12. Voeller H., Truica C., and Gelmann E. β-catenin mutations in human prostate cancer. Cancer Res. 58 (1998) 2520-2523
13. Miyoshi Y., Iwao K., Nagasawa Y., Aihara T., Sasaki Y., Imaoka S., Murata M., Shimano T., and Nakamura Y. Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving Exon 3. Cancer Res. 58 (1998) 2524-2527
14. Lin S.Y., Xia W., Wang J.C., Kwong K.Y., Spohn B., Wen Y., Pestell R.G., and Hung M.C. β-Catenin, a novel prognostic marker for breast cancer, its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. USA 97 (2000) 4262-4266
15. Holmen S.L., Zylstra C.R., Mukherjee A., Sigler R.E., Faugere M.C., Bouxsein M.L., Deng L., Clemens T.L., and Williams B.O. Essential role of beta-catenin in postnatal bone acquisition. J. Biol. Chem. 280 (2005) 21162-21168
16. Gaur T., Lengner C.J., Hovhannisyan H., Bhat R.A., Bodine P.V., Komm B.S., Javed A., van Wijnen A.J., Stein J.L., Stein G.S., and Lian J.B. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J. Biol. Chem. 280 (2005) 33132-33140
17. Goldring S.R., and Goldring M.B. Eating bone or adding it: the Wnt pathway decides. Nat. Med. 13 (2007) 133-134
18. Campanacci M., Baldini N., Boriani S., and Sudanese A. Giant-cell tumor of bone. J. Bone Joint Surg. 69-A (1987) 106-114
19. Glass II D.A., and Karsenty G. Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway. Curr. Top Dev. Biol. 73 (2006) 43-84
20. Glass II D.A., Bialek P., Ahn J.D., Starbuck M., Patel M.S., Clevers H., Taketo M.M., Long F., McMahon A.P., Lang R.A., and Karsenty G. Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8 (2005) 751-764
21. Spencer G.J., Utting J.C., Etheridge S.L., Arnett T.R., and Genever P.G. Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkB ligand and inhibits osteoclastogenesis in vitro. J. Cell Sci. 119 (2006) 1283-1296
22. Soonpaa M.H., Koh G.Y., Pajak L., Jing S., Wang H., Franklin M.T., Kim K.K., and Field L.J. Cyclin D1 overexpression promotes cardiomyocytes DNA synthesis and multinucleation in transgenic mice. J. Clin. Invest. 99 (1997) 2644-2654
23. Palazon L.S., Davies T.J., and Gardner R.L. Translational inhibition of cyclin B1 and appearance of cyclin D1 very early in the differentiation of mouse trophoblast giant cells. Mol. Hum. Reprod. 4 (1998) 1013-1020
24. Sun S., Zimmet J.M., Toselli P., Thompson A., Jackson C.W., and Ravid K. Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes. Haematologica 86 (2001) 17-23
25. Grano M., Colucci S., De Bellis M., Zigrino P., Argentino L., Zambonin G., Serra M., Scotlandi K., Teti A., and Zambonin Zallone A. New model for bone resorption study in vitro: human osteoclast-like cells from giant cell tumors of bone. J. Bone Miner. Res. 9 (1994) 1013-1020
26. Sulh M.A., Greco M.A., Jiang T., Goswami S.B., Present D., and Steiner G. Proliferation index and vascular density of giant cell tumors of bone: are they prognostic markers?. Cancer 77 (1996) 2044-2051
27. Masui F., Ushigome S., and Fujii K. Giant cell tumor of bone: an immunohistochemical comparative study. Pathol. Int. 48 (1998) 355-361
28. Scotlandi K., Serra M., Manara M.C., Maurici D., Benini S., Nini G., Campanacci M., and Baldini N. Clinical relevance of Ki-67 expression in bone tumors. Cancer 75 (1995) 806-814