Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 1056-1061

  Zarghi, Afshin ^a   Praveen Rao, P N ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cyclooxygenase inhibition; Methanesulfonamido pharmacophore; Rofecoxib analogues

Indexed keywords

3 (4 BROMOPHENYL) 4 (4 METHYLSULFONAMIDOPHENYL) 2(5H) FURANONE; 3 (4 CHLOROPHENYL) 4 (4 METHYLSULFONAMIDOPHENYL) 2(5H) FURANONE; 3 (4 FLUOROPHENYL) 4 (4 METHYLSULFONAMIDOPHENYL) 2(5H) FURANONE; 3 (4 METHOXYPHENYL) 4 (4 METHYLSULFONAMIDOPHENYL) 2(5H) FURANONE; 3 (4 METHYLPHENYL) 4 (4 METHYLSULFONAMIDOPHENYL) 2(5H) FURANONE; 4 (4 METHYLSULFONAMIDOPHENYL) 3 PHENYL 2(5H) FURANONE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; SULFONAMIDE;

ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; INDICATORS AND REAGENTS; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONES;

EID: 33845322682     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.023     Document Type: Article

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