Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin

European Journal of Pharmacology

Volumn 616, Issue 1-3, 2009, Pages 48-57

  Fontana, Andréia C K ^a   Sonders, Mark S ^b   Pereira Junior, Olavo S ^c   Knight, Matty ^d   Javitch, Jonathan A ^b   Rodrigues, Vanderlei ^c   Amara, Susan G ^a   Mortensen, Ole V ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Allele; Drug target; Gene expression; Parasite; Serotonin transporter; SERT

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 6 NITROQUIPAZINE; CHLORPROMAZINE; CITALOPRAM; CLOMIPRAMINE; COMPLEMENTARY DNA; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; MESSENGER RNA; METITEPINE; PAROXETINE; SEROTONIN; SEROTONIN TRANSPORTER;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; ELECTRON TRANSPORT; GENE EXPRESSION; GENE LOCUS; IC 50; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHISTOSOMA MANSONI; SNAIL; SPOROCYST;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; COS CELLS; DNA, COMPLEMENTARY; ELECTRIC CONDUCTIVITY; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LIFE CYCLE STAGES; MALE; MICE; MOLECULAR SEQUENCE DATA; OOCYTES; PROTEIN ISOFORMS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SUBSTRATE SPECIFICITY; XENOPUS LAEVIS;

EID: 67651089647     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.023     Document Type: Article

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