Direct metabolic fingerprinting of commercial herbal tinctures by nuclear magnetic resonance spectroscopy and mass spectrometry

Phytochemical Analysis

Volumn 20, Issue 4, 2009, Pages 328-334

  Politi, Matteo ^a,b   Zloh, Mire ^b   Pintado, Manuel E ^a   Castro, Paula M L ^a   Heinrich, Michael ^b   Prieto, Jose M ^b  

^a UNIVERSIDADE CATÓLICA PORTUGUESA   (Portugal)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Herbal medicinal products; Mass spectrometry; Nuclear magnetic resonance; Quality control; Tinctures

Indexed keywords

CHEMICAL DETECTION; DIRECT INJECTION; ETHANOL; METABOLISM; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANTS (BOTANY); QUALITY CONTROL;

ANALYTICAL TOOL; CHEMICAL DIVERSITY; DIRECT ANALYSIS; ETHANOL-WATER SOLUTIONS; HERBAL MEDICINAL PRODUCT; MEDICINAL PLANTS; MEDICINAL PRODUCTS; METABOLIC FINGERPRINTING; PHARMACEUTICAL PREPARATIONS; TINCTURE;

MASS SPECTROMETRY;

ECHINACEA PURPUREA EXTRACT; GINKGO BILOBA EXTRACT; HYPERICUM PERFORATUM EXTRACT; VALERIAN; ALCOHOL; PLANT EXTRACT; WATER;

ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG METABOLISM; HERBAL MEDICINE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; TINCTURE; CHEMISTRY; MEDICINAL PLANT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ECHINACEA PURPUREA; GINKGO BILOBA; HYPERICUM PERFORATUM; VALERIANA OFFICINALIS;

ETHANOL; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PLANT EXTRACTS; PLANTS, MEDICINAL; WATER;

EID: 67651018994     PISSN: 09580344     EISSN: 10991565     Source Type: Journal    
DOI: 10.1002/pca.1131     Document Type: Article

References (24)

1. Araujo AS, da Rocha LL, Tomazela DM, Sawaya AC, Almeida RR, Catharino RR and Eberlin MN. 2005. Electrospray ionization mass spectrometry fingerprinting of beer. Analyst 130: 884-889.
2. Bilia AR, Salvini D, Mazzi G and Vincieri FF. 2001a. Characterization of Calendula flower, milk-thistle fruit, and passion flower tinctures by HPLC-DAD and HPLC-MS. Chromatographia 53: 210-215.
3. Bilia AR, Bergonzi MC, Mazzi G and Vincieri, FF. 2001b. Analysis of plant complex matrices by use of nuclear magnetic resonance spectroscopy: St. John's wort extract. J Agric Food Chem 49: 2115-2124.
4. 2 arnica extract. J Pharm Biomed Anal 30, 321-330.
5. Bilia AR, Eterno F, Bergonzi MC, Mazzi G and Vincieri FF. 2007. Evaluation of the content and stability of the constituents of mother tinctures and tinctures: the case of Crataegus oxyacantha L. and Hieracium pilosella L. J Pharm Biomed Anal 44: 70-78.
6. Catharino RR, Cunha IBS, Fogaca AO, Facco EMP, Godoy HT, Daudt CE, Eberlin MN and Sawaya ACHF. 2006. Characterization of must and wine of six varieties of grapes by direct infusion electrospray ionization mass spectrometry. J Mass Spectrom 41: 185-190.
7. 1H-NMR. Phytochem Anal 15: 325-330.
8. Dalby-Brown L, Barsett H, Landbo AK, Meyer AS and Molgaard P. 2005. Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins. J Agric Food Chem 53: 9413-9423.
9. de Souza PP, Siebald HG, Augusti DV, Neto WB, Amorim VM, Catharino RR, Eberlin MN and Augusti R. 2007. Electrospray ionization mass spectrometry fingerprinting of Brazilian artisan cachaca aged in different wood casks. J Agric Food Chem 55, 2094-2102.
10. Duarte I, Barros A, Belton PS, Righelato R, Spraul M, Humpfer E and Gil AM. 2002. High-resolution nuclear magnetic resonance spectroscopy and multivariate analysis for the characterization of beer. J Agric Food Chem 50: 2475-2481.
11. Dunn WB, Bailey NJ and Johnson HE. 2005. Measuring the metabolome: current analytical technologies. Analyst 130: 606-625.
12. EMEA, 1999. Stability tests. HMPWG 25/99: 48.
13. Heinrich M, 2008. Ethnopharmacy and natural product research - multidisciplinary opportunities for research in the metabolomic age. Phytochem Lett 1: 1-5.
14. Holmes E, Tang H, Wang Y and Seger C. 2006. The assessment of plant metabolite profiles by NMR-based methodologies. Planta Med 72: 771-785.
15. Liang YZ, Xie P and Chan K. 2004. Quality control of herbal medicines. J Chromatogr 812: 53-70.
16. Marcocci L, Maguire JJ, Droy-Lefaix MT and Packer L. 1994a. The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761. Biochem Biophys Res Commun 201: 748-755.
17. Marcocci L, Packer L, Droy-Lefaix MT, Sekaki A and Gardes-Albert M. 1994b. Antioxidant action of Ginkgo biloba extract EGb 761. Meth Enzymol 234: 462-475.
18. Modarai M, Gertsch J, Suter A, Heinrich M and Kortenkamp A. 2007. Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content. J Pharm Pharmacol 59: 567-573.
19. Pauli GF. 2001. qNMR - a versatile concept for the validation of natural product reference compounds. Phytochem Anal 12: 28-42.
20. Politi M, Chavez MI, Canada FJ and Jiménez-Barbero J. 2005. Screening by NMR: A new approach for the study of bioactive natural products? The example of Pleurotus ostreatus hot water extract. Eur J Org Chem 1392-1396.
21. Politi M, Peschel W, Wilson N, Zloh M, Prieto JM and Heinrich M. 2008. Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on delta9-THC and delta9-THC-acid. Phytochemistry 69: 562-570.
22. Taggi AE, Meinwald J and Schroeder FC. 2004. A new approach to natural products discovery exemplified by the identification of sulfated nucleosides in spider venom. J Am Chem Soc 126: 10364-10369.
23. Tyler VE. 1999. Phytomedicines: back to the future. J Nat Prod 62: 1589-1592.
24. Williamson EM. 2001. Synergy and other interactions in phytomedicines. Phytomedicine 8: 401-409.