Ethnopharmacy and natural product research-Multidisciplinary opportunities for research in the metabolomic age

Phytochemistry Letters

Volumn 1, Issue 1, 2008, Pages 1-5

  Heinrich, Michael ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bioactive natural products; Ethnopharmacology; Ethnopharmacy; Metabolomics; Phytochemical analysis; Traditional medicine

Indexed keywords

ALKALOID; ANTHRAQUINONE DERIVATIVE; AYURVEDIC DRUG; BAICALEIN; BAICALIN; BENZOPHENONE DERIVATIVE; BRUCINE; DRONABINOL; EPHEDRA EXTRACT; FLAVONOID; HERBACEOUS AGENT; HYPERICUM PERFORATUM EXTRACT; ICAJINE; LOGANIN; MATRICARIA RECUTITA EXTRACT; MELATONIN; NATURAL PRODUCT; NUTRACEUTICAL; PLANT EXTRACT; SCUTELLARIA BAICALENSIS EXTRACT; SUNGUCINE; TANACETUM PARTHENIUM EXTRACT; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG; VACCINIUM ANGUSTIFOLIUM EXTRACT; WOGONIN; XANTHONE DERIVATIVE;

AYURVEDA; BIOLOGICAL ACTIVITY; CHINESE MEDICINE; CULTURAL FACTOR; DRUG IDENTIFICATION; DRUG RESEARCH; DRUG SCREENING; ECOSYSTEM; EPHEDRA; ETHNOPHARMACOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERICUM PERFORATUM; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MATRICARIA; MEDICAL RESEARCH; MEDICINAL PLANT; METABOLOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYTOCHEMISTRY; PLANT MORPHOLOGY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITATIVE ANALYSIS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REVIEW; SCUTELLARIA BAICALENSIS; SPECIES DIVERSITY; STRYCHNOS; TANACETUM PARTHENIUM; TOXICITY TESTING; TRADITIONAL MEDICINE; VACCINIUM; VACCINIUM ANGUSTIFOLIUM;

EID: 41249095864     PISSN: 18743900     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytol.2007.11.003     Document Type: Review

References (26)

1. 1H NMR spectroscopy and chemometrics. Planta Med. 68 8 (2002) 734-738
2. Corson T.W., and Crews C.M. Molecular understanding and modern application of traditional medicines: Triumphs and trials. Cell 130 (2007) 769-774
3. Cragg G.M., and Newman D.J. Plants as a source of anti-cancer agents. J. Ethnopharmacol. 100 (2005) 72-79
4. Duarte I., Barros A., Belton P.S., Righelato R., Spraul M., Humpfer E., et al. High-resolution nuclear magnetic resonance spectroscopy and multivariate analysis for the characterization of beer. J. Agric. Food Chem. 50 (2002) 2475-2481
5. Dunn W.B., Bailey N.J., and Johnson H.E. Measuring the metabolome: Current analytical technologies. Analyst 130 (2005) 606-625
6. 1H nuclear magnetic resonance spectrometry and multivariate analysis techniques. Phytochemistry 65 13 (2004) 1993-2001
7. Harris C.S., Burt A.J., Saleem A., Le P.M., Martineau L.C., Haddad P.S., et al. A single HPLC-PAD-APCI/MS method for the quantitative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium. Phytochem. Anal. 18 2 (2007) 161-169
8. Heinrich, M. (2001). Ethnobotanik und Ethnopharmazie. Wissenschaftliche Verlagsgesellschaft. Stuttgart (Germany).
9. Heinrich M., and Gibbons S. Ethnopharmacology in drug discovery: An analysis of its role and potential contributions. J. Pharm. Pharmacol. 53 (2001) 425-432
10. Heinrich M., Heneka B., Ankli A., Rimpler H., Sticher O., and Kostiza T. Antisecretory and antispasmodic activity of polymethoxylated flavonoids from Casimiroa tetrameria. J. Pharm. Pharmacol. 57 (2005) 1081-1085
11. Heinrich M., and Teoh H.L. Galanthamine from snowdrop-The development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J. Ethnopharmacol. 92 (2004) 147-162 10.1016/j.jep.2004.02.012
12. Hör M., Rimpler H., and Heinrich M. Inhibition of intestinal chloride secretion by proanthocyanidins from Guazuma ulmifolia. Planta Med. 61 3 (1995) 208-212
13. Kim H.K., Choi Y.H., Erkelens C., Lefeber A.W.M., and Verpoorte R. Metabolic fingerprinting of Ephedra species using H NMR spectroscopy and principal component analysis. Chem. Pharm. Bull. (Tokyo) 53 1 (2005) 105-109
14. Murch S.J., Rupasinghe H.P.V., Goodenowe D., and Saxena P.K. A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: Discovery of novel compounds. Plant Cell Rep. 23 6 (2004) 419-425
15. Phillipson J.D. Phytochemistry and pharmacognosy. Phytochemistry 68 (2007) 2960-2972
16. 9-THC. Phytochemistry 69 (2008) 562-570
17. Politi M., Sanogo R., Ndjoko K., Guilet D., Wolfender J.-L., Hostettmann K., et al. HPLC-UV/PAD and HPLC-MSn analyses of leaf and root extracts of Vismia guineensis and isolation and identification of two new bianthrones. Phytochem. Anal. 15 6 (2004) 355-364
18. Raskin I., Ribnicky D.M., Komarnytsky S., Ilic N., Poulev A., Borisjuk N., et al. Plants and human health 21st century. Trends Biotechnol. 20 (2002) 522-531
19. Rasmussen B., Cloarec O., Tang H., Staerk D., and Jaroszewski J.W. Multivariate analysis of integrated and full-resolution H-1 NMR spectral data from complex pharmaceutical preparations: St. John's wort. Planta Medica 72 6 (2006) 556-563
20. Schmidt B.M., Ribnicky D.M., Lipsky P.E., and Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat. Chem. Biol. 3 (2007) 360-366
21. Verpoorte R., Choi Y.H., and Kim H.K. Ethnopharmacology and systems biology: A perfect holistic match. J. Ethnopharmacol. 100 (2005) 53-56
22. Verpoorte R., Choi Y.H., and Kim H.K. NMR-based metabolomics at work in phytochemistry. Phytochem. Rev. 6 (2007) 3-14
23. Wang M., Lamers R.J.A.N., Korthout H.A., van Nesselrooij J.H.J., Witkamp R.F., van der Heijden R., et al. Metabolomics in the context of systems biology: Bridging traditional Chinese medicine and molecular pharmacology. Phytother. Res. 19 January (3) (2005) 173-182
24. Wang Y., Tang H., Nicholson J.K., Hylands P.J., Sampson J., Whitcombe I., et al. Metabolomic strategy for the classification and quality control of phytomedicine: A case study of chamomile flower (Matricaria recutita L.). Planta Med. 70 3 (2004) 250-255
25. Weckwerth W., and Morgenthal K. Metabolomics: From pattern recognition to biological interpretation. Drug Disc. Today 10 (2005) 1551-1557
26. Williamson E.M. Synergy and other interactions in phytomedicines. Phytomedicine 8 (2001) 401-409