Relationships Among Plasma Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate, Cortisol, Symptoms of Dissociation, and Objective Performance in Humans Exposed to Underwater Navigation Stress

Biological Psychiatry

Volumn 66, Issue 4, 2009, Pages 334-340

  Morgan III, Charles A ^a,b   Rasmusson, Ann ^c,d   Pietrzak, Robert H ^a,b   Coric, Vladimir ^a   Southwick, Steven M ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

Cognitive; hormones; military; performance; special forces; stress

Indexed keywords

HYDROCORTISONE; PRASTERONE; PRASTERONE SULFATE;

ADULT; AIR FORCE; ARMY; ARTICLE; COGNITION; DISSOCIATION; DIVER; HORMONE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; LINEAR REGRESSION ANALYSIS; MALE; MINNESOTA MULTIPHASIC PERSONALITY INVENTORY; NAVY; NIGHT; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; RADIOIMMUNOASSAY; SALIVA ANALYSIS; SEA; SOLDIER; STRESS; SWIMMING; SYMPTOM; TASK PERFORMANCE;

ADULT; COGNITION; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DISSOCIATIVE DISORDERS; HUMANS; HYDROCORTISONE; MILITARY PERSONNEL; SALIVA; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL; TASK PERFORMANCE AND ANALYSIS;

EID: 67651014472     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.04.004     Document Type: Article

References (56)

1. Nieschlag E., Loriaux D.L., Ruder H.J., Zucker I.R., Kirschner M.A., and Lipsett M.B. The secretion of dehydroepiandrosterone and dehydroepiandrosterone sulphate in man. J Clin Endocrinol 57 (1973) 123-134
2. A receptor. Brain Res 526 (1990) 143-146
3. Compagnone N.A., and Mellon S.H. Neurosteroids: Biosynthesis and function of these novel neuromodulators. Front Neuroendocrinol 21 (2000) 1-56
4. Melchior C.L., and Ritzmann R.F. Dehydroepiandrosterone is an anxiolytic in mice on the plus maze. Pharmacol Biochem Behav 47 (1994) 437-441
5. Robel P., and Baulieu E.E. Dehydroepiandrosterone (DHEA) is a neuroactive neurosteroid. Ann N Y Acad Sci 774 (1995) 82-110
6. Roberts E. Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) as neural facilitators: Effects on brain tissue in culture and on memory in young and old mice: A cyclic GMP hypothesis of action of DHEA and DHEAS in nervous system and other tissues. In: Kalimi M., and Regelson W. (Eds). The Biologic Role of Dehydroepiandrosterone (DHEA) (1990), W De Gruyter, Berlin 13-42
7. Kimonides V.G., Khatibi N.H., Svendsen C.N., Sofroniew M.V., and Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci U S A 95 (1998) 1852-1857
8. Kimonides V.G., Spillantini M.G., Sofroniew M.V., Fawcett J.W., and Herbert J. Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures. Neuroscience 89 (1999) 429-436
9. Orentreich N., Brind J.L., Rizer R.L., and Vogelman J.H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 75 (1992) 1002-1004
10. Orentreich N., Brind J.L., Bogelman J.H., Andres R., and Baldwin H. Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. J Clin Endocrinol Metab 59 (1992) 551-555
11. Sulcova J., Hill M., and Starka L. Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects. J Endocrinol 154 (1997) 57-62
12. Zumoff B., Walter L., Rosenfeld R.S., Strain J.J., Degen K., Strain G.W., et al. Subnormal plasma adrenal androgen levels in men with uremia. J Clin Endocrinol Metab 51 (1980) 801-805
13. Floreani A., Titta M., Plebani M., Faggian D., Chiaramonte M., and Naccarato R. Sex hormone changes in post-menopausal women with primary biliary cirrhosis (PBC) and with cryptogenic chronic liver disease. Clin Exp Obstet Gynecol 18 (1991) 229-234
14. Yamauchi A., Takei I., Kasuga A., Kitamura Y., Ohashi N., Nakano S., et al. Depression of dehydroepiandrosterone in Japanese diabetic men-comparison between non-insulin dependent diabetes mellitus and impaired glucose tolerance. Eur J Endocrinol 135 (1996) 101-104
15. Herrington D.M., Gordon G.B., Achuff S.C., Trejo J.F., Weisman H.J., Kwitervich P.O., and Pearson T.A. Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. J Am Coll Cardiol 16 (1990) 862-870
16. Masi A.T. Sex hormones and rheumatoid arthritis: Cause or effect relationships in a complex pathophysiology?. Clin Exp Rheumatol 13 (1995) 227-240
17. Salahuddin F., Svec F., and Dinan T.G. Low DHEA and DHEA-S levels in patients with chronic fatigue syndrome. J Investig Med 45 (1997) 56A
18. Goodyer I.M., Herbert J., Altham P.M.E., Pearson J., Secher S.M., and Shiers H.M. Adrenal secretion during major depression in 8-16 year olds: 1. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychol Med 26 (1996) 245-256
19. Wolkowitz O.M., Reus V.I., Roberts E., Manfredi F., Chan T., Raum W.J., et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry 41 (1997) 311-318
20. Micheal A., Jenaway A., Paykel E.S., and Herbert J. Altered salivary dehydroepiandrosterone levels in major depression in adults. Biol Psychiatry 48 (2000) 989-995
21. Goodyer I.M., Herbert J., and Altham P.M.E. Adrenal steroid secretion and major depression in 8-16 year olds. III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression. Psychol Med 28 (1998) 253-255
22. Fava M., Rosenbaum J.F., MacLaughlin R.A., Tesar G.E., Pollack M.H., Cohen L.S., and Hirsch M. Dehydroepiandrosterone-sulfate/cortisol ratio in panic disorder. Psychiatry Res 28 (1989) 345-350
23. Zumoff B., Walsh B.T., Katz J.L., Levin J., Rosenfeld R.S., Kream J., and Weiner H. Subnormal plasma dehydroepiandrosterone to cortisol ratio in anorexia nervosa: A second hormonal parameter of ontogenic regression. J Clin Endocrinol Metab 56 (1983) 668-672
24. Oades R.D., and Schepker R. Serum gonadal steroid hormones in young schizophrenic patients. Psychoneuroendocrinology 19 (1994) 373-385
25. Soendergaard H.P., Hansson L.-O., and Theorell T. Elevated blood levels of dehydroepiandrosterone sulphate vary with symptom load in posttraumatic stress disorder: Findings from a longitudinal study of refugees in Sweden. Psychother Psychosom 71 (2002) 298-303
26. Soendergaard H.P., and Theorell T. A longitudinal study of hormonal reactions accompanying life events in recently resettled refugees. Psychother Psychosom 72 (2003) 49-58
27. Morgan III C.A., Hazlett G.A., Rasmusson A., Zimolo Z., Southwick S.M., and Charney D.S. Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation and objective performance in humans exposed to acute stress. Arch Gen Psychiatry 61 (2004) 819-825
28. Shrager Y., Bayley P.J., Bontempi B., Hopkins R.O., and Squire L.R. Spatial memory and the human hippocampus. Proc Natl Acad Sci U S A 104 (2007) 2961-2966
29. Astur R.S., Taylor L.B., Mamelak A.N., Philpott L., and Sutherland R.J. Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task. Behav Brain Res 132 (2002) 77-84
30. Burgess N., Maguire E.A., and O'Keefe J. The human hippocampus and spatial and episodic memory. Neuron 35 (2002) 625-641
31. Maguire E.A., Woollett K., and Spiers H.J. London taxi drivers and bus drivers: A structural MRI and neuropsychological analysis. Hippocampus 16 (2006) 1091-1101
32. Basso D., Lotze M., Vitale L., Ferreri F., Bisiacchi P., Olivetti Belardinelli M., et al. The role of prefrontal cortex in visuo-spatial planning: A repetitive TMS study. Exp Brain Res 171 (2006) 411-415
33. Hagler Jr. D.J., and Sereno M.I. Spatial maps in frontal and prefrontal cortex. Neuroimage 29 (2006) 567-577
34. Slotnick S.D., and Moo L.R. Prefrontal cortex hemispheric specialization for categorical and coordinate visual spatial memory. Neuropsychologia 44 (2006) 1560-1568
35. Pham K., McEwen B., Ledoux J.E., and Nader K. Far learning transiently impairs hippocampal cell proliferation. Neuroscience 130 (2005) 17-24
36. Karishma K.K., and Hebert J. Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression. Eur J Neurosci 16 (2002) 445-453
37. Shi J., Shulze S., and Lardy H.A. The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids 65 (2000) 124-129
38. Charney D.S. The neurobiology of anxiety disorders. In: Charney D., Nestler E.J., and Bunney B.S. (Eds). Neurobiology of Mental Illness (1999), Oxford University Press, New York 494-517
39. Moghaddam B. Stress activation of glutamate neurotransmission in the prefrontal cortex: Implications for dopamine-associated psychiatric disorders. Biol Psychiatry 51 (2002) 775-787
40. Morgan III C.A., Aikins D., Steffian G., Coric V., and Southwick S.M. Relation between cardiac vagal tone and performance in male military personnel exposed to high stress: Three prospective studies. Psychophysiology 44 (2007) 120-127
41. Bremner J.D., Krystal J.H., Putnam F.W., Southwick S.M., Marmar C., Charney D.S., and Mazure C.M. Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS). J Trauma Stress 11 (1998) 125-136
42. Morris R.G., Garrud P., Rawlins J.N., and O'Keefe J. Place-navigation impaired in rats with hippocampal lesions. Nature 297 (1982) 681-683
43. Oitzl M.S., Fluttert M., and de Kloet E.R. Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats. Brain Res 797 (1998) 159-162
44. van Niekerk J.K., Huppert F.A., and Herbert J. Salivary cortisol and DHEA: Association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation. Psychoneuroendocrinology 26 (2001) 591-612
45. Alhaj H.A., Massey A.E., and McAllister-Williams R.H. Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: A double-blind, placebo-controlled study. Psychopharmacology (Berl) 188 (2006) 541-551
46. Morgan III C.A., Doran A., Steffian G., Hazlett G., and Southwick S.M. Stress induced deficits in working memory and visuoconstructive abilities in special operations soldiers. Biol Psychiatry 60 (2006) 722-729
47. Grootendoorst J., Kempes M.M., Lucassen P.J., Dalm S., de Kloet E.R., and Oitzl M.S. Differential effect of corticosterone on spatial learning abilities in apoliproprotein E knockout and C57BL/6J mice. Brain Res 953 (2002) 281-285
48. Efthimia K., Olympia K., Dionyssios Y., Michalis A., and Christos K. Spatial performance and corticosteroid receptor status in the 21-day restraint stress paradigm. Ann N Y Acad Sci 1018 (2004) 323-327
49. Demirgoren S., Majewska M.D., Spivak C.E., and London E.D. Receptor binding and electrophysiological effects of dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor. Neuroscience 45 (1991) 127-135
50. Fleshner M., Pugh C.R., Tremblay D., and Rudy J.W. DHEA-S selectively impairs contextual-fear conditioning: Support for the antiglucocorticoid hypothesis. Behav Neurosci 111 (1997) 512-517
51. Bastianetto S., Ramassamy C., Poirier J., and Quirion R. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Mol Brain Res 66 (1999) 35-41
52. Kaminska M., Harris J., Gilsbers K., and Dubrovsky B. Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. Implications for depression. Brain Res Bull 52 (2000) 229-234
53. Bremmer J.D., Southwick S., Brett E., Fontana A., Rosenheck R., and Charney D.S. Dissociation and posttraumatic stress disorder in Vietnam combat veterans. Am J Psychiatry 149 (1992) 328-332
54. Anand A., Charney D.S., Oren D.A., Berman R.M., Hu X.S., Cappiello A., and Krystal J.H. Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: Support for hyperglutamatergic effects of N-methly-D-aspartate receptor antagonists. Arch Gen Psychiatry 57 (2000) 270-276
55. Gusenoff J.A., Harman S.M., Veldhuis J.D., Jayme J.J., St. Clair C., Munzer T., et al. Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men. Am J Physiol Endocrinol Metab 280 (2001) E616-E625
56. Ravaglia G., Forti P., Maioli F., Boschi F., Bernardi M., Pratelli L., et al. The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. J Clin Endocrinol Metab 81 (1996) 1173-1178