The Relationship of Dehydroepiandrosterone Sulfate (DHEAS) to Endocrine-Metabolic Parameters and Functional Status in the Oldest-Old. Results from an Italian Study on Healthy Free-Living Over-Ninety-Year-Olds

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 3, 1996, Pages 1173-1178

  Ravaglia, Giovanni ^a,b   Forti, Paola ^a   Maioli, Fabiola ^a   Boschi, Federica ^a   Bernardi, Mauro ^a   Pratelli, Loredana ^b   Pizzoferrato, Arturo ^b   Gasbarrini, Giovanni ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GROWTH HORMONE; HYDROCORTISONE; PRASTERONE SULFATE;

AGED; AGING; ARTICLE; BODY COMPOSITION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONE RELEASE; HUMAN; HYDROCORTISONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STATISTICAL ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ACTIVITIES OF DAILY LIVING; ADULT; AGED; AGED, 80 AND OVER; AGING; BODY CONSTITUTION; BODY MASS INDEX; DEHYDROEPIANDROSTERONE SULFATE; ENDOCRINE GLANDS; HUMANS; MIDDLE AGED; TRIGLYCERIDES; TRIIODOTHYRONINE;

EID: 0029862990     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.81.3.8772596     Document Type: Article

References (45)

1. Meikle AW, Daynes RA, Araneo BA. 1991 Adrenal androgen secretion and biologic effects. Endocrinol Metab Clin North Am. 20:381-400.
2. Tsagarakis S, Grossman A. 1991 The hypothalamic-pituitary-adrenal axis in senescence. In: Morley JE, Korenman SG, eds. Endocrinology and metabolism in the elderly. Boston: Blackwell Scientific Publications; 70-91.
3. Sciaira F, Vermeulen A. 1987 Gli androgeni corticosurrenalici. In: Conti C, Piro C, Vermeulen A, eds. Steroidi androgeni. Fisiopatologia e Clinica. Parma:IBS; 121-136.
4. Rosenfeld RS, Rosemberg BJ, Fukushima DK, Hellman L. 1975 24-hour secretory pattern of dehydroisoandrostenedione and dehydroisoandrostenedione-sulfate. J Clin Endocrinol Metab. 40:850-855.
5. Birkenhager-Gillesse EG, Derksen J, Lagaay AM. 1994 Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over. Ann NY Acad Sci. 719:543-552.
6. Aron DC, Tyrrel JB. 1994 Glucocorticoids and adrenal androgens. In: Greenspan FS, Baxter JD, eds. Basic and Clinical Endocrinology. 4th ed. Appleton and Lange. London: Prentice Hall International; 307-346.
7. Ebeling P, Koivisto VA. 1994 Physiological importance of dehydroepiandrosterone. Lancet. 343:1479-1481.
8. Schneider EL, Reed JD. 1985 Life extension. N Engl J Med. 312:1159-1168.
9. Helzlsouer KJ, Gordon GB, Alberg A, Bush TL, Comstock GW. 1992 Relationship of prediagnostic serum levels of DHEA and DHEAS to the risk of developing premenopausal breast cancer. Cancer Res. 52:1-4.
10. Thoman ML, Weigle WO. 1989 The cellular and subcellular bases of immunoeescence. Adv Immunol. 46:221-226.
11. Barrett-Connor E, Khaw KT, Yen SSC. 1986 A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med. 315:1519-1524.
12. Barrett-Connor E, Khaw KT. 1987 Absence of an inverse relation of dehydroepiandrosterone sulfate with cardiovascular mortality in postmenopausal women. N Engl J Med. 317:711.
13. Rudman D, Shetty KR, Mattson DE. 1990 Plasma dehydroepiandrosterone sulfate in nursing home men. J Am Geriatr Soc. 38:421-427.
14. Hauner H, Stangl K, Burger K, Busch U, Blomer H, Pfeiffer EF. 1991 Sex hormone concentrations in men with angiographically assessed coronary artery disease. Relationship to obesity and body fat distribution. Klin Wochenschr. 69:664-668.
15. Rudman D, Kutner C, Rogers CM, Lubin MF, Fleming GA, Bain RP. 1981 Impaired growth hormone secretion in the adult population. Relation to age and adiposity. J Clin Invest. 67:1361-1369.
16. Mariotti S, Barbesino G, Caturegli P, et al. 1993 Complex alterations of thyroid function in healthy centenarians. J Clin Endocrinol Metab. 77:1130-1134.
17. Going SB, Lohman TG. 1994 Aging and body composition. In: Watson RR, ed. Handbook of nutrition in the aged. 2nd ed. Boca Raton: CRC Press; 57-71.
18. Nestler JE, Barlascini CO, Clore JN, Blackard GB. 1988 Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab. 66:57-61.
19. Welle S, Jozefowicz R, Statt M. 1990 Failure of dehydroepiandrosterone to influence energy and protein metabolism in humans. J Clin Endocrinol Metab. 71:1259-1264.
20. Mortola JF, Yen SSC. 1990 The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab. 71:696-704.
21. Morales AJ, Nolan JJ, Nelson JC, Yen SSC. 1994 Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab. 78:1360-1367.
22. Berkman LF, Seeman TE, Albert M, et al. 1993 High, usual and impaired functioning in community-dwelling older men and women: findings from the MacArthur foundation research network on successful aging. J Clin Epidemiol. 46:1129-1140.
23. Ligthart GJ, Corberaud JX, Fournier C, et al. 1984 Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Aging Dev. 28:47-55.
24. De Peretti E, Forest M. 1978 Pattern of plasma dehydroepiandrosterone sulfate levels in humans from birth to adulthood: evidence for testicular production. J Clin Endocrinol Metab. 47:572-577.
25. Thomas G, Frenoy N, Legrain S, Sebag-Lanoe R, Baulieu EM, Deburie B. 1994 Serum dehydroepiandrosterone sulfate levels as an individual marker. J Clin Endocrinol Metab. 79:1273-1276.
26. Berga SL, Mortola JF, Girton L, et al. 1989 Neuroendocrine aberrations in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab. 68:301-308.
27. Hintz RL, Lui F, Marshall LB, Chang D. 1980 Interaction of somatomedin-C with an antibody directed against the synthetic C-peptide region of insulin-like growth factor I. J Clin Endocrinol Metab. 50:405-407.
28. Daughaday WH, Mariz IK, Blethen SL. 1980 Inhibition of assessed bound somatomedin to membrane receptor in immunoblotting sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol extracted serum. J Clin Endocrinol Metab. 51:781-788.
29. Furlanetto RW, Underwood LE, Van Wyck JJ, D'Ercole AJ. 1977 Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassays. J Clin Invest. 60:648-657.
30. Segal P, Bachorik P, Rifkind B, Levy R. 1984 Lipids and dyslipoproteinemia. In: Henry RB, ed. Clinical diagnosis and management by laboratory methods. Philadelphia: Saunders; 186-193.
31. Lohman TG, Roche AF, Martorell R, eds. 1988 Anthropometric standardization reference manual. Champain, IL: Human Kinetics Books.
32. Katz S, Dowms TD, Cash HR, et al. 1970 Progress in the development of an index of ADL. Gerontologist. 10:20-30.
33. Orentreich N, Brind JL, Rizer RL, Vogelman JH. 1984 Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 59:551-555.
34. Schneider EL, Reed JD. 1985 Life extension. N Engl J Med. 312:1159-1168.
35. Tietz NW, Shuey DF, Wekstein DR. 1992 Laboratory values in fit aging individuals. Sexagenarians through centenarians. Clin Chem. 38:1167-1185.
36. Ben-David M, Dikstein S, Bismuth G, Sulman PG. 1967 Antihypercholesterolemic effect of dehydroepiandrosterone in rats. Proc Soc Exp Biol Med. 125:1136-1140.
37. Salvini S, Stampfer MJ, Barbieri RL, Henneken CH. 1992 Effects of age, smoking and vitamins on plasma DHEAS levels: a cross-sectional study in men. J Clin Endocrinol Metab. 74:139-143.
38. Frisancho AR. 1981 New norms of upper limb fat and muscle area for assessment of nutritional status. Am J Clin Nutr. 34:2540-2545.
39. Vellas B, Chumlea WC, Beziat F, et al. 1992 Etude des normes anthropométriques dans une population française de 492 personnes ageées en bonne santé et vivant a domicile. L'Anné Gerontologique. 203-217.
40. Delarue J, Constans T, Malvy D, Pradignac A, Couet C, Lamisse F. 1994 Anthropometric values in an elderly French population. Br J Nutr. 71:295-302.
41. Burr ML, Phillips KM. 1984 Anthropometric norms in the elderly. Br J Nutr. 51:165-169.
42. Chumlea WC, Baumgartner RN, Vellas BP. 1991 Anthropometry and body composition in the perspective of nutritional status in the elderly. Nutrition. 7:57-60.
43. Seidell JC, Oosterlee A, Thijssen MAO, et al. 1987 Assessment of intra-abdominal and subcutaneous abdominal fat: relation between anthropometry and computed tomography. Am J Clin Nutr. 45:7-13.
44. Williams DP, Boyden TW, Pamenter RW, Lohman TG, Going SB. 1993 Relationship of body fat percentage and fat distribution with dehydroepiandrosterone sulfate in premenopausal females. J Clin Endocrinol Metab. 77:80-85.
45. Bjorntorp P. 1993 Endocrine insufficiency and nutrition in aging. Aging Clin Exp Res. 5(Suppl, 1):45-49.