Ultra-performance liquid chromatographic-electrospray mass spectrometric determination (UPLC-ESI-MS) of O-demethylated metabolite of paeonol in vitro: Assay development, human liver microsome activities and species differences

Talanta

Volumn 79, Issue 5, 2009, Pages 1433-1440

  Liu, Hui Xin ^a,b   Hu, Ying ^a   He, Yu Qi ^c   Liu, Yong ^a   Li, Wei ^a,b   Yang, Ling ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Enzyme kinetics; Human liver microsomes; O Demethylation; Paeonol; Species differences; Ultra performance liquid chromatography

Indexed keywords

CHEMICAL REACTIONS; ENZYME KINETICS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; RATS;

HUMAN LIVER MICROSOMES; O-DEMETHYLATION; PAEONOL; SPECIES DIFFERENCES; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

LIVER;

EID: 67650995432     PISSN: 00399140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.talanta.2009.06.018     Document Type: Article

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