Species differences in inhibition potential of nonsteroidal anti-inflammatory drugs against estradiol 3β-glucuronidation between rats, dogs, and humans

Journal of Pharmaceutical Sciences

Volumn 97, Issue 7, 2008, Pages 2805-2810

  Mano, Yuji ^a   Usui, Takashi ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Drug interactions; Glucuronosyltransferases (UGT); Inhibition; Metabolite kinetics; Microsomes

Indexed keywords

DICLOFENAC; DIFLUNISAL; ESTRADIOL 3BETA GLUCURONIDE; ESTRADIOL DERIVATIVE; FENOPROFEN; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; KETOPROFEN; MEFENAMIC ACID; NIFLUMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; SULINDAC; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DOG; DRUG STRUCTURE; GLUCURONIDATION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LIVER MICROSOME; MICHAELIS CONSTANT; NONHUMAN; RAT; SPECIES DIFFERENCE;

EID: 52449118771     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21185     Document Type: Article

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