Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes

Biochemical Pharmacology

Volumn 75, Issue 3, 2008, Pages 752-760

  Narimatsu, Shizuo ^a   Yonemoto, Rei ^a   Masuda, Kazufumi ^a   Katsu, Takashi ^a   Asanuma, Masato ^a   Kamata, Tooru ^b   Katagi, Munehiro ^b   Tsuchihashi, Hitoshi ^b   Kumamoto, Takuya ^c   Ishikawa, Tsutomu ^c   Naito, Shinsaku ^d   Yamano, Shigeru ^e   Hanioka, Nobumitsu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Chuo ward   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^e FUKUOKA UNIVERSITY   (Japan)

Author keywords

5 Methoxy N,N diisopropyltryptamine; 6 Hydroxylation; CYP1A1; CYP2C11; CYP2D2; CYP3A2; N Deisopropylation; O Demethylation; Rat

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME; CYTOCHROME P 450 CYP2C11; CYTOCHROME P 450 CYP2C6; CYTOCHROME P 450 CYP2D2; CYTOCHROME P 450 CYP3A2; CYTOCHROME P450; CYTOCHROME P450 1A1; DESIGNER DRUG; N,N DIISOPROPYL 5 METHOXYTRYPTAMINE; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DEALKYLATION; DEMETHYLATION; DRUG METABOLISM; FEMALE; KINETICS; LIVER MICROSOME; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

5-METHOXYTRYPTAMINE; ANIMALS; BETA-NAPHTHOFLAVONE; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS;

EID: 37849008946     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.09.019     Document Type: Article

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