Salmonella Induces Flagellin- and MyD88-Dependent Migration of Bacteria-Capturing Dendritic Cells Into the Gut Lumen

Gastroenterology

Volumn 137, Issue 2, 2009, Pages

  Arques, Juan L ^a   Hautefort, Isabelle ^a   Ivory, Kamal ^a   Bertelli, Eugenio ^b   Regoli, Marì ^b   Clare, Simon ^c   Hinton, Jay C D ^a,d   Nicoletti, Claudio ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b UNIVERSITY OF SIENA   (Italy)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; MYELOID DIFFERENTIATION FACTOR 88;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL POPULATION; CONFOCAL MICROSCOPY; DENDRITIC CELL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LARGE INTESTINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA; SALMONELLOSIS; SMALL INTESTINE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 67650948293     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.04.010     Document Type: Article

References (29)

1. Neutra M.R., Mantis N.J., and Kraehenbuhl J.P. Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat Immunol 2 (2001) 1004-1009
2. Rimoldi M., Chieppa M., Salucci V., et al. Intestinal homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 6 (2005) 507-514
3. Zeuthen L.H., Fink L.N., and Frokiaer H. Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor β. Immunology 123 (2008) 197-208
4. Mowat A.M. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 4 (2003) 331-341
5. Sansonetti P.J. War and peace at mucosal surfaces. Nat Rev Immunol 4 (2004) 953-964
6. Nicoletti C. Unsolved mysteries of intestinal M cells. Gut 47 (2000) 735-739
7. Jang M.H., Kweon M., Iwatani K., et al. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci USA 101 (2004) 6110-6115
8. Rescigno M., Urbano M., Valzasina B., et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2 (2001) 361-367
9. Niess J.H., Brand S., Gu X., et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307 (2005) 254-258
10. Chieppa M., Rescigno M., Huang A.Y., et al. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 203 (2006) 2841-2852
11. Becker C., Wirtz S., Blessing M., et al. Constitutive p40 promoter activation and IL-23production in the terminal ileum mediated by dendritic cells. J Clin Invest 112 (2003) 693-706
12. Adachi O., Kawai T., Takeda K., et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9 (1998) 143-150
13. Edwards A.D., Manickasingham S.P., Spörri R., et al. Microbial recognition via Toll-like receptor dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J Immunol 169 (2002) 3652-3660
14. Hayashi F., Smith K.D., Ozinsky A., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 (2001) 10099-10103
15. Rhee S.H., Kim H., Moyer M.P., et al. Role of MyD88 inphosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem 281 (2006) 18560-18568
16. Stoll S., Delon J., Brotz T.M., et al. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296 (2002) 1815-1817
17. Sierro F., Dubois B., Coste A., et al. Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci U S A 98 (2001) 13722-137227
18. Rescigno M., Urbano M., Rittig M., et al. Interaction of dendritic cells with bacteria. In: Lotze M.T., and Thomson A.W. (Eds). Dendritic cells: biology and clinical application (2001), Academic Press, Eastbourne, UK 473-486
19. Jang M.H., Sougawa N., Tanaka T., et al. CCR7 is critical important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 176 (2006) 803-810
20. Regoli M., Borghesi C., Bertelli E., et al. A morphological study of the lymphocyte traffic in Peyer's patches after an in vivo antigenic stimulation. Anat Rec 239 (1994) 47-54
21. Gewirtz A.T., Simon Jr. P.O., Schmitt C.K., et al. Salmonella typhimurium translocates flagellin across intestinal epithelia inducing a pro-inflammatory response. J Clin Invest 107 (2001) 99-109
22. Lyons S., Wang L., Casanova J.E., et al. Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway. J Cell Sci 117 (2004) 5771-5780
23. Penn C.W., and Luke C.J. Bacterial flagellar diversity and significance in pathogenesis. FEMS Microbiol Lett 79 (1992) 331-336
24. Rumbo M., Nempont C., Kraehenbuhl J.P., et al. Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5. FEBS Lett 580 (2006) 2976-2984
25. Vallon-Eberhard A., Landsman L., Yogev N., et al. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol 176 (2006) 2465-2469
26. Iwasaki A. Mucosal dendritic cells. Annu Rev Immunol 25 (2007) 381-418
27. Heatley R.V., and Bienenstock J. Luminal lymphoid cells in the rabbit intestine. Gastroenterology 82 (1982) 268-275
28. Brandtzaeg P. Induction of secretory immunity and memory at mucosal surfaces. Vaccine 25 (2007) 5467-5484
29. Matthias K.A., Roche A.M., Standish A.J., et al. Neutrophil-toxin interactions promote antigen delivery and mucosal clearance of Steptococcus pneumoniae. J Immunol 180 (2008) 6246-6254