CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis

Drug Metabolism and Disposition

Volumn 37, Issue 8, 2009, Pages 1682-1689

  Subramanian, Murali ^a   Low, Michael ^a   Locuson, Charles W ^b   Tracy, Timothy S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; FLURBIPROFEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONCENTRATION RESPONSE; DEMETHYLATION; DRUG METABOLISM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP2D6; DEALKYLATION; DEXTROMETHORPHAN; DEXTRORPHAN; FLURBIPROFEN; HUMANS; HYDROXYLATION; KINETICS; MODELS, BIOLOGICAL; NADPH-FERRIHEMOPROTEIN REDUCTASE; SPECTRUM ANALYSIS; SUBSTRATE SPECIFICITY;

ANIMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 67650809065     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.026500     Document Type: Article

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