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Volumn 39, Issue 1, 2007, Pages 45-60

Pharmacogenetic screening of the gene deletion and duplications of CYP2D6

Author keywords

Cytochrome 2D6; Gene deletion; Gene duplication; Pharmacogenetics

Indexed keywords

ALPRENOLOL; AMITRIPTYLINE; ANTIARRHYTHMIC AGENT; ANTIDEPRESSANT AGENT; APRINDINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CITALOPRAM; CLOMIPRAMINE; CLOZAPINE; CYTOCHROME P450 2D6; DESIPRAMINE; ENCAINIDE; FLECAINIDE; FLUOXETINE; FLUVOXAMINE; HALOPERIDOL; METOPROLOL; MEXILETINE; NEUROLEPTIC AGENT; OLANZAPINE; PERHEXILINE; PERPHENAZINE; PROPAFENONE; PROPRANOLOL; RISPERIDONE; THIORIDAZINE; TIMOLOL; UNINDEXED DRUG; ZUCLOPENTHIXOL;

EID: 33847018803     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530600952206     Document Type: Article
Times cited : (34)

References (55)
  • 1
    • 0034911155 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP2D6
    • Abraham, A. (2001). Genetic polymorphism of CYP2D6. Indian J. Pharmacol. 33:147-169.
    • (2001) Indian J. Pharmacol , vol.33 , pp. 147-169
    • Abraham, A.1
  • 2
    • 0036409283 scopus 로고    scopus 로고
    • The detection of large deletions or duplications in genomic DNA
    • Armour, J. A., Barton, D. E., Cockburn, D. J., Taylor, G. R. (2002). The detection of large deletions or duplications in genomic DNA. Hum. Mutat. 20:325-337.
    • (2002) Hum. Mutat , vol.20 , pp. 325-337
    • Armour, J.A.1    Barton, D.E.2    Cockburn, D.J.3    Taylor, G.R.4
  • 3
    • 0028211009 scopus 로고
    • PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates
    • Barnes, W. M. (1994). PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc. Natl. Acad. Sci. USA 91:2216-2220.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2216-2220
    • Barnes, W.M.1
  • 4
    • 0036204756 scopus 로고    scopus 로고
    • Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs
    • Bertilsson, L., Dahl, M. L., Dalen, P., Al-Shurbaji, A. (2002). Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs. Br. J. Clin. Pharmacol. 53:111-122.
    • (2002) Br. J. Clin. Pharmacol , vol.53 , pp. 111-122
    • Bertilsson, L.1    Dahl, M.L.2    Dalen, P.3    Al-Shurbaji, A.4
  • 5
    • 31044436017 scopus 로고    scopus 로고
    • Determination of cytochrome P450 2D6 (CYP2D6) gene copy number by real-time quantitative PCR
    • Bodin, L., Beaune, P. H., Loriot, M. A. (2005). Determination of cytochrome P450 2D6 (CYP2D6) gene copy number by real-time quantitative PCR. J. Biomed. Biotechnol. 2005:248-253.
    • (2005) J. Biomed. Biotechnol , vol.2005 , pp. 248-253
    • Bodin, L.1    Beaune, P.H.2    Loriot, M.A.3
  • 6
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford, L. D. (2002). CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 3:229-243.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 7
    • 0029622336 scopus 로고
    • An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis
    • Broly, F., Marez, D., Sabbagh, N., Legrand, M., Millecamps, S., Lo Guidice, J. M., Boone, P., Meyer, U. A. (1995). An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis. Pharmacogenetics 5:373-384.
    • (1995) Pharmacogenetics , vol.5 , pp. 373-384
    • Broly, F.1    Marez, D.2    Sabbagh, N.3    Legrand, M.4    Millecamps, S.5    Lo Guidice, J.M.6    Boone, P.7    Meyer, U.A.8
  • 8
    • 0028261194 scopus 로고
    • Effective amplification of long targets from cloned inserts and human genomic DNA
    • Cheng, S., Fockler, C., Barnes, W. M., Higuchi, R. (1994). Effective amplification of long targets from cloned inserts and human genomic DNA. Proc. Natl. Acad. Sci. USA 91:5695-5699.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5695-5699
    • Cheng, S.1    Fockler, C.2    Barnes, W.M.3    Higuchi, R.4
  • 10
    • 0037081031 scopus 로고    scopus 로고
    • Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction
    • Endrizzi, K., Fischer, J., Klein, K., Schwab, M., Nussler, A., Neuhaus, P., Eichelbaum, M., Zanger, U. M. (2002). Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction. Anal. Biochem. 300:121-131.
    • (2002) Anal. Biochem , vol.300 , pp. 121-131
    • Endrizzi, K.1    Fischer, J.2    Klein, K.3    Schwab, M.4    Nussler, A.5    Neuhaus, P.6    Eichelbaum, M.7    Zanger, U.M.8
  • 11
    • 0042843050 scopus 로고    scopus 로고
    • Cytochrome p450 genotyping by multiplexed real-time DNA sequencing with pyrosequencing technology
    • Eriksson, S., Berg, L. M., Wadelius, M., Alderborn, A. (2002). Cytochrome p450 genotyping by multiplexed real-time DNA sequencing with pyrosequencing technology. Assay Drug Dev. Technol. 1:49-59.
    • (2002) Assay Drug Dev. Technol , vol.1 , pp. 49-59
    • Eriksson, S.1    Berg, L.M.2    Wadelius, M.3    Alderborn, A.4
  • 12
    • 0025805934 scopus 로고
    • Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
    • Gaedigk, A., Blum, M., Gaedigk, R., Eichelbaum, M., Meyer, U. A. (1991). Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am. J. Hum. Genet. 48:943-950.
    • (1991) Am. J. Hum. Genet , vol.48 , pp. 943-950
    • Gaedigk, A.1    Blum, M.2    Gaedigk, R.3    Eichelbaum, M.4    Meyer, U.A.5
  • 13
    • 0036278859 scopus 로고    scopus 로고
    • Gene quantification using real-time quantitative PCR: An emerging technology hits the mainstream
    • Ginzinger, D. G. (2002). Gene quantification using real-time quantitative PCR: An emerging technology hits the mainstream. Exp. Hematol. 30:503-512.
    • (2002) Exp. Hematol , vol.30 , pp. 503-512
    • Ginzinger, D.G.1
  • 14
    • 14944377644 scopus 로고    scopus 로고
    • Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: Effects on cell survival, cell cycle and pharmacogenetic profile
    • Giovannetti, E., Mey, V., Danesi, R., Basolo, F., Barachini, S., Deri, M., Del Tacca, M. (2005). Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: Effects on cell survival, cell cycle and pharmacogenetic profile. Br. J. Cancer 92:681-689.
    • (2005) Br. J. Cancer , vol.92 , pp. 681-689
    • Giovannetti, E.1    Mey, V.2    Danesi, R.3    Basolo, F.4    Barachini, S.5    Deri, M.6    Del Tacca, M.7
  • 15
    • 0035710229 scopus 로고    scopus 로고
    • An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression
    • Giulietti, A., Overbergh, L., Valckx, D., Decallonne, B., Bouillon, R., Mathieu, C. (2001). An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression. Methods 25:386-401.
    • (2001) Methods , vol.25 , pp. 386-401
    • Giulietti, A.1    Overbergh, L.2    Valckx, D.3    Decallonne, B.4    Bouillon, R.5    Mathieu, C.6
  • 17
    • 0023954396 scopus 로고
    • Human debrisoquine 4-hydroxylase (P450IID1): CDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22
    • Gonzalez, F. J., Vilbois, F., Hardwick, J. P., McBride, O. W., Nebert, D. W., Gelboin, H. V., Meyer, U. A. (1988b). Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics 2:174-179.
    • (1988) Genomics , vol.2 , pp. 174-179
    • Gonzalez, F.J.1    Vilbois, F.2    Hardwick, J.P.3    McBride, O.W.4    Nebert, D.W.5    Gelboin, H.V.6    Meyer, U.A.7
  • 18
    • 0027480849 scopus 로고
    • Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis
    • Gough, A. C., Smith, C. A., Howell, S. M., Wolf, C. R., Bryant, S. P., Spurr, N. K. (1993). Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis. Genomics 15:430-432.
    • (1993) Genomics , vol.15 , pp. 430-432
    • Gough, A.C.1    Smith, C.A.2    Howell, S.M.3    Wolf, C.R.4    Bryant, S.P.5    Spurr, N.K.6
  • 19
    • 0034234293 scopus 로고    scopus 로고
    • Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: Association of polymorphisms with functional differences in estrogen hydroxylation activity
    • Hanna, I. H., Dawling, S., Roodi, N., Guengerich, F. P., Parl, F. F. (2000). Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. Cancer Res. 60:3440-3444.
    • (2000) Cancer Res , vol.60 , pp. 3440-3444
    • Hanna, I.H.1    Dawling, S.2    Roodi, N.3    Guengerich, F.P.4    Parl, F.F.5
  • 20
    • 0025080352 scopus 로고
    • Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification
    • Heim, M., Meyer, U. A. (1990). Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification. Lancet 336:529-532.
    • (1990) Lancet , vol.336 , pp. 529-532
    • Heim, M.1    Meyer, U.A.2
  • 21
    • 0026629691 scopus 로고
    • Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6
    • Heim, M. H., Meyer, U. A. (1992). Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. Genomics 14:49-58.
    • (1992) Genomics , vol.14 , pp. 49-58
    • Heim, M.H.1    Meyer, U.A.2
  • 22
    • 0028488561 scopus 로고
    • Methods and reagents. Long and accurate PCR
    • Hengen, P. N. (1994). Methods and reagents. Long and accurate PCR. TIBS 19:341-342.
    • (1994) TIBS , vol.19 , pp. 341-342
    • Hengen, P.N.1
  • 23
    • 0033871198 scopus 로고    scopus 로고
    • Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR
    • Hersberger, M., Marti-Jaun, J., Rentsch, K., Hanseler, E. (2000). Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR. Clin. Chem. 46:1072-1077.
    • (2000) Clin. Chem , vol.46 , pp. 1072-1077
    • Hersberger, M.1    Marti-Jaun, J.2    Rentsch, K.3    Hanseler, E.4
  • 24
    • 0033791142 scopus 로고    scopus 로고
    • High throughput detection of drug-metabolizing enzyme polymorphisms by allele-specific fluorogenic 5′ nuclease chain reaction assay
    • Hiratsuka, M., Agatsuma, Y., Omori, F., Narahara, K., Inoue, T., Kishikawa, Y., Mizugaki, M. (2000). High throughput detection of drug-metabolizing enzyme polymorphisms by allele-specific fluorogenic 5′ nuclease chain reaction assay. Biol. Pharm. Bull. 23:1131-1135.
    • (2000) Biol. Pharm. Bull , vol.23 , pp. 1131-1135
    • Hiratsuka, M.1    Agatsuma, Y.2    Omori, F.3    Narahara, K.4    Inoue, T.5    Kishikawa, Y.6    Mizugaki, M.7
  • 25
    • 0025861818 scopus 로고
    • Detection of specific polymerase chain reaction product by utilizing the 5′ - 3′ exonuclease activity of Thermus aquaticus DNA polymerase
    • Holland, P. M., Abramson, R .D., Watson, R., Gelfand, D. H. (1991). Detection of specific polymerase chain reaction product by utilizing the 5′ - 3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc. Natl. Acad. Sci. USA 88:7276-7280.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7276-7280
    • Holland, P.M.1    Abramson, R.D.2    Watson, R.3    Gelfand, D.H.4
  • 26
    • 1942421701 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
    • Ingelman-Sundberg, M. (2004). Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future. Trends Pharmacol. Sci. 25:193-200.
    • (2004) Trends Pharmacol. Sci , vol.25 , pp. 193-200
    • Ingelman-Sundberg, M.1
  • 27
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
    • Ingelman-Sundberg, M. (2005). Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 5:6-13.
    • (2005) Pharmacogenomics J , vol.5 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 28
    • 33644664657 scopus 로고    scopus 로고
    • Pharmacogenetics of drug-metabolizing enzymes: Implications for a safer and more effective drug therapy
    • Ingelman-Sundberg, M., Rodriguez-Antona, C. (2005). Pharmacogenetics of drug-metabolizing enzymes: Implications for a safer and more effective drug therapy. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360:1563-1570.
    • (2005) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.360 , pp. 1563-1570
    • Ingelman-Sundberg, M.1    Rodriguez-Antona, C.2
  • 30
    • 0024796958 scopus 로고
    • The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
    • Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A., Gonzalez, F. J. (1989). The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am. J. Hum. Genet. 45:889-904.
    • (1989) Am. J. Hum. Genet , vol.45 , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 31
    • 23844516328 scopus 로고    scopus 로고
    • Pharmacogenetics-based therapeutic recommendations - ready for clinical practice?
    • Kirchheiner, J., Fuhr, U., Brockmoller, J. (2005). Pharmacogenetics-based therapeutic recommendations - ready for clinical practice? Nat. Rev. Drug Discov. 4:639-647.
    • (2005) Nat. Rev. Drug Discov , vol.4 , pp. 639-647
    • Kirchheiner, J.1    Fuhr, U.2    Brockmoller, J.3
  • 32
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • Kirchheiner, J., Nickchen, K., Bauer, M., Wong, M. L., Licinio, J., Roots, I., Brockmoller, J. (2004). Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response. Mol. Psychiatry 9:442-473.
    • (2004) Mol. Psychiatry , vol.9 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3    Wong, M.L.4    Licinio, J.5    Roots, I.6    Brockmoller, J.7
  • 33
    • 19644377185 scopus 로고    scopus 로고
    • Identification of subtypes of CYP2D gene rearrangements among carriers of CYP2D6 gene deletion and duplication
    • Ledesma, M. C., Agundez, J. A. (2005). Identification of subtypes of CYP2D gene rearrangements among carriers of CYP2D6 gene deletion and duplication. Clin. Chem. 51:939-943.
    • (2005) Clin. Chem , vol.51 , pp. 939-943
    • Ledesma, M.C.1    Agundez, J.A.2
  • 34
    • 0007293059 scopus 로고    scopus 로고
    • Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene
    • Lovlie, R., Daly, A. K., Molven, A., Idle, J. R., Steen, V. M. (1996). Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene. FEBS Lett. 392:30-34.
    • (1996) FEBS Lett , vol.392 , pp. 30-34
    • Lovlie, R.1    Daly, A.K.2    Molven, A.3    Idle, J.R.4    Steen, V.M.5
  • 35
    • 0033590590 scopus 로고    scopus 로고
    • Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes
    • Lundqvist, E., Johansson, I., Ingelman-Sundberg, M. (1999). Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes. Gene 226:327-338.
    • (1999) Gene , vol.226 , pp. 327-338
    • Lundqvist, E.1    Johansson, I.2    Ingelman-Sundberg, M.3
  • 36
    • 0036020649 scopus 로고    scopus 로고
    • Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics
    • Mattison, L. K., Soong, R., Diasio, R. B. (2002). Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics. Pharmacogenomics 3:485-492.
    • (2002) Pharmacogenomics , vol.3 , pp. 485-492
    • Mattison, L.K.1    Soong, R.2    Diasio, R.B.3
  • 37
    • 0036009619 scopus 로고    scopus 로고
    • The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics
    • McLeod, H. L., Siva, C. (2002). The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics. Pharmacogenomics 3:89-98.
    • (2002) Pharmacogenomics , vol.3 , pp. 89-98
    • McLeod, H.L.1    Siva, C.2
  • 38
    • 0025259226 scopus 로고
    • The genetic polymorphism of debrisoquine/ sparteine metabolism-molecular mechanisms
    • Meyer, U. A., Skoda, R. C., Zanger, U. M. (1990). The genetic polymorphism of debrisoquine/ sparteine metabolism-molecular mechanisms. Pharmacol. Ther. 46:297-308.
    • (1990) Pharmacol. Ther , vol.46 , pp. 297-308
    • Meyer, U.A.1    Skoda, R.C.2    Zanger, U.M.3
  • 40
    • 17444453992 scopus 로고    scopus 로고
    • Optimized strategy for rapid cytochrome P450 2D6 genotyping by real-time long PCR
    • Muller, B., Zopf, K., Bachofer, J., Steimer, W. (2003). Optimized strategy for rapid cytochrome P450 2D6 genotyping by real-time long PCR. Clin. Chem. 49:1624-1631.
    • (2003) Clin. Chem , vol.49 , pp. 1624-1631
    • Muller, B.1    Zopf, K.2    Bachofer, J.3    Steimer, W.4
  • 42
    • 0035861049 scopus 로고    scopus 로고
    • Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review
    • Phillips, K. A., Veenstra, D. L., Oren, E., Lee, J. K., Sadee, W. (2001). Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review. JAMA 286:2270-2279.
    • (2001) JAMA , vol.286 , pp. 2270-2279
    • Phillips, K.A.1    Veenstra, D.L.2    Oren, E.3    Lee, J.K.4    Sadee, W.5
  • 44
    • 0033921510 scopus 로고    scopus 로고
    • Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction
    • Roberts, R., Joyce, P., Kennedy, M. A. (2000). Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction. Hum. Mutat. 16:77-85.
    • (2000) Hum. Mutat , vol.16 , pp. 77-85
    • Roberts, R.1    Joyce, P.2    Kennedy, M.A.3
  • 45
    • 33644683245 scopus 로고    scopus 로고
    • Rapid detection of common cytochrome P450 2D6 alleles in Caucasians
    • Roberts, R. L., Kennedy, M. A. (2006). Rapid detection of common cytochrome P450 2D6 alleles in Caucasians. Clin. Chim. Acta 366:348-351.
    • (2006) Clin. Chim. Acta , vol.366 , pp. 348-351
    • Roberts, R.L.1    Kennedy, M.A.2
  • 46
    • 0346363770 scopus 로고    scopus 로고
    • CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR
    • Schaeffeler, E., Schwab, M., Eichelbaum, M., Zanger, U. M. (2003). CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR. Hum. Mutat. 22:476-485.
    • (2003) Hum. Mutat , vol.22 , pp. 476-485
    • Schaeffeler, E.1    Schwab, M.2    Eichelbaum, M.3    Zanger, U.M.4
  • 47
    • 0034974138 scopus 로고    scopus 로고
    • Genotyping of cytochrome P450 2D6*3 and *4 mutations using conventional PCR
    • Schur, B. C., Bjerke, J., Nuwayhid, N., Wong, S. H. (2001). Genotyping of cytochrome P450 2D6*3 and *4 mutations using conventional PCR. Clin. Chim. Acta 308:25-31.
    • (2001) Clin. Chim. Acta , vol.308 , pp. 25-31
    • Schur, B.C.1    Bjerke, J.2    Nuwayhid, N.3    Wong, S.H.4
  • 48
    • 2342578875 scopus 로고    scopus 로고
    • MLPA and MAPH: New techniques for detection of gene deletions
    • Sellner, L. N., Taylor, G. R. (2004). MLPA and MAPH: New techniques for detection of gene deletions. Hum. Mutat. 23:413-419.
    • (2004) Hum. Mutat , vol.23 , pp. 413-419
    • Sellner, L.N.1    Taylor, G.R.2
  • 49
    • 1642483471 scopus 로고    scopus 로고
    • Feed-forward regulation of bile acid detoxification by CYP3A4 - Studies in humanized transgenic mice
    • Stedman, C., Robertson, G., Coulter, S., Liddle, C. (2004). Feed-forward regulation of bile acid detoxification by CYP3A4 - Studies in humanized transgenic mice. J. Biol. Chem. 279:11336-11343.
    • (2004) J. Biol. Chem , vol.279 , pp. 11336-11343
    • Stedman, C.1    Robertson, G.2    Coulter, S.3    Liddle, C.4
  • 51
    • 0031923119 scopus 로고    scopus 로고
    • Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication
    • Steijns, L. S., Van Der Weide, J. (1998). Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication. Clin. Chem. 44:914-917.
    • (1998) Clin. Chem , vol.44 , pp. 914-917
    • Steijns, L.S.1    Van Der Weide, J.2
  • 52
    • 0029846193 scopus 로고    scopus 로고
    • Rapid detection of CYP2D6 null alleles by long distance- and multiplex-polymerase chain reaction
    • Stuven, T., Griese, E. U., Kroemer, H. K., Eichelbaum, M., Zanger, U. M. (1996). Rapid detection of CYP2D6 null alleles by long distance- and multiplex-polymerase chain reaction. Pharmacogenetics 6:417-421.
    • (1996) Pharmacogenetics , vol.6 , pp. 417-421
    • Stuven, T.1    Griese, E.U.2    Kroemer, H.K.3    Eichelbaum, M.4    Zanger, U.M.5
  • 54
    • 0344012538 scopus 로고    scopus 로고
    • Real-time polymerase chain reaction
    • Wilhelm, J., Pingoud, A. (2003). Real-time polymerase chain reaction. ChemBioChem. 4:1120-1128.
    • (2003) ChemBioChem , vol.4 , pp. 1120-1128
    • Wilhelm, J.1    Pingoud, A.2
  • 55
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
    • Zanger, U. M., Raimundo, S., Eichelbaum, M. (2004). Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch. Pharmacol. 369:23-37.
    • (2004) Naunyn Schmiedebergs Arch. Pharmacol , vol.369 , pp. 23-37
    • Zanger, U.M.1    Raimundo, S.2    Eichelbaum, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.