Reexcitation mechanisms in epicardial tissue: Role of Ito density heterogeneities and INa inactivation kinetics

Journal of Theoretical Biology

Volumn 259, Issue 4, 2009, Pages 850-859

  Cantalapiedra, Inma R ^a   Peñaranda, Angelina ^a   Mont, Lluis ^b   Brugada, Josep ^b   Echebarria, Blas ^a  

^a UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Arrhythmia; Brugada syndrome; Dispersion of refractoriness; Phase 2 reentry; Ventricular fibrillation

Indexed keywords

CALCIUM CHANNEL L TYPE; SODIUM CHANNEL;

BIOLOGY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; NUMERICAL MODEL; WAVE PROPAGATION;

ARTICLE; BRUGADA SYNDROME; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CHANNEL GATING; CONTROLLED STUDY; EPICARDIUM; HEART MUSCLE POTENTIAL; HEART PROARRHYTHMIA; HEART REPOLARIZATION; HEART VENTRICLE FIBRILLATION; POTASSIUM CURRENT; PRIORITY JOURNAL; REENTRY ARRHYTHMIA; REFRACTORY PERIOD; SODIUM CURRENT;

ACTION POTENTIALS; BRUGADA SYNDROME; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARDIAC PACING, ARTIFICIAL; HUMANS; ION CHANNEL GATING; MODELS, CARDIOVASCULAR; PERICARDIUM; SODIUM CHANNELS;

EID: 67650741731     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.04.021     Document Type: Article

References (32)

1. Aiba T., Shimizu W., Hidaka I., Uemura K., Noda T., Zheng C., Kamiya A., Inagaki M., Sugimachi M., and Sunagawa K. Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model-high-resolution optical mapping study. J. Am. Coll. Cardiol. 47 (2006) 2074-2085
2. Antzelevitch C. Heterogeneity and cardiac arrhythmias: an overview. Heart Rhythm 4 (2007) 964-972
3. Antzelevitch C. Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am. J. Physiol. Heart Circ. Physiol. 293 (2007) H2024-H2038
4. Antzelevitch C., Brugada P., Brugada J., and Brugada R. The Brugada Syndrome: From Bench to Bedside (2005), UK: Blackwell Futura, Oxford
5. Antzelevitch C., Brugada P., Borggrefe M., Brugada J., Brugada R., Corrado D., Gussak I., LeMarec H., Nademanee K., Perez Riera AR., Shimizu W., Schulze-Bahr E., Tan H., and Wilde A. Brugada syndrome: report of the second consensus conference. Heart Rhythm 2 (2005) 429-440
6. Antzelevitch C., Pollevick GD., Cordeiro JM., Casis O., Sanguinetti MC., Aizawa Y., Guerchicoff A., Pfeiffer R., Oliva A., Wollnik B., Gelber P., Bonaros EP., Burashnikov E., Wu Y., Sargent JD., Schickel S., Oberheiden R., Bhatia A., Hsu L.-F., Haïssaguerre M., Schimpf R., Borggrefe M., and Wolpert C. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 115 (2007) 442-449
7. to) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J. Gen. Physiol. 113 (1999) 581-600
8. Brugada P., and Brugada J. Right bundle block, persistent ST segment elevation and cardiac death: a distinct clinical electrocardiographic syndrome-a multicenter report. J. Am. Coll. Cardiol. 20 (1992) 1391-1396
9. Casini S., Tan HL., Bhuiyan ZA., Bezzina CR., Barnett P., Cerbai E., Mugelli A., Wilde AAM., and Veldkamp MW. Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation. Cardiovasc. Res. 76 (2007) 418-429
10. Chen Q., Kirsch GE., Zhang D., Brugada R., Brugada J., Brugada P., Potenza D., Moya A., Borggrefe M., Breithardt G., Ortiz-Lopez R., Wang Z., Antzelevitch C., O'Brien RE., Schulze-Bahr E., Keating MT., Towbin JA., and Wang Q. Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation. Nature 392 (1998) 293-296
11. Clancy CE., and Rudy Y. Na+ channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation 105 (2002) 1208-1213
12. 0-induced electrical heterogeneity and extrasystolic activity in isolated canine ventricular epicardium: phase 2 reentry. Circulation 89 (1994) 1839-1850
13. Dumaine R., Towbin JA., Brugada P., Vatta M., Nesterenko DW., and Nesterenko VV. Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. Circ. Res. 85 (1999) 803-809
14. Grant AO., Carboni MP., Neplioueva V., Starmer CF., Memmi M., Napolitano C., and Priori S. Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation. J. Clin. Invest. 110 (2002) 1201-1209
15. Hopenfeld B. Mechanism for action potential alternans: the interplay between L-type calcium current and transient outward current. Heart Rhythm 3 (2006) 345-352
16. Hund TJ., and Rudy Y. Determinants of excitability in cardiac myocytes: mechanistic investigation of memory effect. Biophys. J. 79 (2000) 3095-3104
17. Inherited Arrhythmias Database. 〈http://www.fxm.it/cardmoc/〉.
18. to1 in myocytes isolated from the human right ventricle. Am. J. Physiol. Heart Circ. Physiol. 275 (1998) H369-H377
19. Lukas A., and Antzelevitch C. Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia. Cardiovasc. Res. 32 (1996) 593-603
20. Luo CH., and Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ. Res. 74 (1994) 1071-1096
21. Makita N., Shirai N., Wang DW., Sasaki K., George AL., Kanno M., and Kitabatake A. Cardiac Na+ channel dysfunction in Brugada syndrome is aggravated by β1-subunit. Circulation 101 (2000) 54-60
22. Márquez MF., Salica G., Hermosillo AG., Pastelin G., Gómez-Flores J., Nava S., and Cárdenas M. Ionic basis of pharmacological therapy in Brugada syndrome. J. Cardiovasc. Electrophysiol. 18 (2007) 234-240
23. Maury P., Hocini M., and Haïssaguerre M. Electrical storms in Brugada syndrome: review of pharmacologic and ablative therapeutic options. Indian Pacing Electrophysiol. J. 5 (2005) 25-34
24. Miyoshi S., Mitamura H., Fujikura K., Fukuda Y., Tanimoto K., Hagiwara Y., Makoto I., and Satoshi O. A mathematical model of phase 2 reentry: role of L-type Ca current. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H1285-H1294
25. Miyoshi S., Mitamura H., Fukuda Y., Tanimoto K., Hagiwara Y., Kanki H., Seiji T., Mitsushige M., Toshihisa M., and Satoshi O. Link between SCN5A mutation and the Brugada syndrome ECG phenotype. Circ. J. 69 (2005) 567-575
26. Morita H., Zipes DP., Lopshire J., Morita ST., and Wu J. T wave alternans in an in vitro canine tissue model of Brugada syndrome. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H421-H428
27. Petitprez S., Jespersen T., Pruvot E., Keller DI., Corbaz C., Schläpfer J., Abriel H., and Kucera JP. Analyses of a novel SCN5A mutation (C1850S): conduction vs repolarization disorder hypotheses in the Brugada syndrome. Cardiovasc. Res. 78 (2008) 494-504
28. Shajahan TK., Sinha S., and Pandit R. Spiral-wave dynamics depend sensitively on inhomogeneities in mathematical models of ventricular tissue. Phys. Rev. E 75 (2007) 011929
29. Tanaka H., Kinoshita O., Uchikawa S., Kasai H., Nakamura M., Izawa A., Yokoseki O., Kitabayashi H., Takahashi W., Yazaki Y., Watanabe N., Imamura H., and Kubo K. Successful prevention of recurrent ventricular fibrillation by intravenous isoproterenol in a patient with Brugada syndrome. PACE 24 (2001) 1293-1294
30. Wilde AA., Antzelevitch C., Borggrefe M., Brugada J., Brugada R., Brugada P., Corrado D., Hauer RNW., Kass RS., Nademanee K., Priori SG., and Towbin JA. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation 106 (2002) 2514-2519
31. Xie F., Qu Z., Garfinkel A., and Weiss JN. Electrophysiological heterogeneity and stability of reentry in simulated cardiac tissue. Am. J. Physiol. Heart Circ. Physiol. 280 (2001) H535-H545
32. Zhang Z.-S., Tranquillo J., Neplioueva V., Bursac N., and Grand AO. Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H399-H407