Determinants of excitability in cardiac myocytes: Mechanistic investigation of memory effect

Biophysical Journal

Volumn 79, Issue 6, 2000, Pages 3095-3104

  Hund, Thomas J ^a   Rudy, Yoram ^a,b,c  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; HEART PACING; HEART VENTRICLE; MATHEMATICAL MODEL; MEMORY;

EID: 0033635691     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76544-1     Document Type: Article

References (36)

1. Boyett, M. R., and B. R. Jewell. 1980. Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart. Prog. Biophys. Mol. Biol. 36:1-52.
2. Buchanan, J. W., Jr., T. Saito, and L. S. Gettes. 1985. The effects of antiarrhythmic drugs, stimulation frequency, and potassium-induced resting membrane potential changes on conduction velocity and dV/dtmax in guinea pig myocardium. Circ. Res. 56:696-703.
3. Chialvo, D. R., D. C. Michaels, and J. Jalife. 1990. Supernormal excitability as a mechanism of chaotic dynamics of activation in cardiac Purkinje fibers. Circ. Res. 66:525-545.
4. Damiano, B. P., and M. R. Rosen. 1984. Effects of pacing on triggered activity induced by early afterdepolarizations. Circulation. 69: 1013-1025.
5. Davidenko, J. M., R. J. Levi, G. Maid, M. V. Elizari, and M. B. Rosenbaum. 1990. Rate dependence and supernormality in excitability of guinea pig papillary muscle. Am J. Physiol. 259:H290-H299.
6. Dominguez, G., and H. A. Fozzard. 1970. Influence of extracellular K+ concentration on cable properties and excitability of sheep cardiac Purkinje fibers. Circ. Res. 26:565-574.
7. Faber, G. M., and Y. Rudy. 2000. Action potential and contractility changes in [Na+]i overloaded cardiac myocytes: a simulation study. Biophys. J. 78:2392-2404.
8. Fast, V. G., and A. G. Kleber. 1997. Role of wavefront curvature in propagation of cardiac impulse. Cardiovasc. Res. 33:258-271.
9. Girouard, S. D., J. M. Pastore, K. R. Laurita, K. W. Gregory, and D. S. Rosenbaum. 1996. Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit. Circulation. 93:603-613.
10. Jack, J. J. B., D. Noble, and R. W. Tsien. 1983. Electric Current Flow in Excitable Cells. Clarendon Press, Oxford.
11. Kucera, J. P., A. G. Kleber, and S. Rohr. 1998. Slow conduction in cardiac tissue. II. Effects of branching tissue geometry. Circ. Res. 83:795-805.
12. Luke, R. A., and J. E. Saffitz. 1991. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J. Clin. Invest. 87: 1594-1602.
13. Luo, C. H., and Y. Rudy. 1991. A model of the ventricular cardiac action potential: depolarization, repolarization, and their interaction. Circ. Res. 68:1501-1526.
14. Luo, C. H., and Y. Rudy. 1994a. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ. Res. 74:1071-1096.
15. Luo, C. H., and Y. Rudy. 1994b. A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circ. Res. 74:1097-1113.
16. Marban, E., S. W. Robinson, and W. G. Wier. 1986. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J. Clin. Invest. 78:1185-1192.
17. Nattel, S. 1999. Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation. Cardiovasc. Res. 42:298-308.
18. Noble, D., and R. B. Stein. 1966. The threshold conditions for initiation of action potentials by excitable cells. J. Physiol (Lond). 187:129-162.
19. Peon, J., G. R. Ferner, and G. K. Moe. 1978. The relationship of excitability to conduction velocity in canine Purkinje tissue. Circ. Res. 43:125-135.
20. Peters, N. S., J. Coromilas, M. S. Hanna, M. E. Josephson, C. Costeas, and A. L. Wit. 1998. Characteristics of the temporal and spatial excitable gap in anisotropic reentrant circuits causing sustained ventricular tachycardia. Circ. Res. 82:279-293.
21. Ravens, U., and H. M. Himmel. 1999. Drugs preventing Na+ and Ca2+ overload. Pharmacol. Res. 39:167-174.
22. Rohr, S., J. P. Kucera, and A. G. Kleber. 1998. Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction. Circ. Res. 83:781-794.
23. Rosen, M. R., I. S. Cohen, P. Danilo, Jr., and S. F. Steinberg. 1998. The heart remembers. Cardiovasc. Res. 40:469-482.
24. Rosenbaum, M. B., H. H. Blanco, M. V. Elizari, J. O. Lazzari, and J. M. Davidenko. 1982. Electronic modulation of the T wave and cardiac memory. Am. J. Cardiol. 50:213-222.
25. Shaw, R. M., and Y. Rudy. 1997a. Electrophysiologic effects of acute myocardial ischemia: a mechanistic investigation of action potential conduction and conduction failure. Circ. Res. 80:124-138.
26. Shaw, R. M., and Y. Rudy. 1997b. Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc. Res. 35:256-272.
27. Shaw, R. M., and Y. Rudy. 1997c. Ionic mechanisms of propagation in cardiac tissue: roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction 'coupling. Circ. Res. 81:727-741.
28. Smith, J. H., C. R. Green, N. S. Peters, S. Rothery, and N. J. Severs. 1991. Altered patterns of gap junction distribution in ischemic heart disease: an immunohistochemical study of human myocardium using laser scanning confocal microscopy. Am. J. Pathol. 139:801-821.
29. Spach, M. S., and P. C. Dolber. 1986. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circ. Res. 58:356-371.
30. Spear, J. F., and E. N. Moore. 1974. Supernormal excitability and conduction in the His-Purkinje system of the dog. Circ. Res. 35:782-792.
31. Ursell, P. C., P. I. Gardner, A. Albala, J. J. Fenoglio, Jr., and A. L. Wit. 1985. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ. Res. 56:436-451.
32. Viswanathan, P. C., R. M. Shaw, and Y. Rudy. 1999. Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 99:2466-2474.
33. Wang, Y., and Y. Rudy. 2000. Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Amer J. Physiol. (Heart). 278:H1019-H1029.
34. Weidmann, S. 1952. The electrical constants of Purkinje fibers. J. Physiol. (Lond). 118:348-360.
35. Zeng, J., K. R. Laurita, D. S. Rosenbaum, and Y. Rudy. 1995. Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circ. Res. 77:140-152.
36. Zeng, J., and Y. Rudy. 1995. Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophys. J. 68:949-964.