Mediation of N-(4-hydoxyphenyl)retinamide-induced apoptosis in human cancer cells by different mechanisms

Cancer Research

Volumn 59, Issue 10, 1999, Pages 2493-2498

  Sun, Shi Yong ^a   Li, Wanbo ^a   Yue, Ping ^a   Lippman, Scott M ^a   Hong, Waun K ^a   Lotan, Reuben ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE; RETINOIC ACID RECEPTOR; RETINOID; SUPEROXIDE DISMUTASE; THIOL;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; FENRETINIDE; HEAD AND NECK NEOPLASMS; HUMANS; LUNG NEOPLASMS; NAPHTHALENES; NEOPLASM PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, RETINOIC ACID; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; TUMOR CELLS, CULTURED;

EID: 0033563006     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Moon, R. C., Pritchard, J. F., Mehta, R. G., Nomides, C. T., Thomas, C. F., and Dinger, N. M. Suppressions of rat mammary cancer development by N-(4-hydroxyphenyl)retinamide (4-HPR) following surgical removal of first palpable tumor. Carcinogenesis (Lond.), 10: 1645-1549, 1989.
2. Pollard, M., Luckert, P. H., and Sporn, M. B. Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl)retinamide. Cancer Res., 51: 3610-3611, 1991.
3. Pienta, K. J., Nguyen, N. M., and Lehr, J. E. Treatment of prostate cancer in the rat with the synthetic retinoid fenretinide. Cancer Res., 53: 224-226, 1993.
4. Formelli, F., and Cleris, L. Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity. Cancer Res., 53: 5374-5376, 1993.
5. Costa, A., Formelli, F., Chiesa, F., Decensi, A., De Palo, G., and Veronesi, U. Prospects of chemoprevention of human cancer with the synthetic retinoid fenretinide. Cancer Res., 54 (Suppl. 7): 2032s-2037s, 1994.
6. Formelli, F., Clerici, M., Campa, T., Di Mauro, M. G., Magni, A., Mascotti, G., Moglia, D., Palo, G. D., Costa, A., and Veronesi, U. Five-year administration of fenretinide: pharmacokinetics and effects on plasma retinol concentrations. J. Clin. Oncol., 11: 2036-2042, 1993.
7. Costa, A., Malone, W., Perloff, M., Buranelli, F., Campa, T., Dossena, G., Magni, A., Pizzichetta, M., Andreoli, C., Vecchio, M. D., Formelli, F., and Barbieri, A. Tolerability of the synthetic retinoid fenretinide (HPR). Eur. J. Cancer Clin. Oncol., 25: 805-808, 1989.
8. De Palo, G., Veronesi, U., Camerini, T., Formelli, F., Mascotti, G., Boni, C., Fosser, V., Vecchio, M. D., Campa, T., Costa, A., and Marubini, E. Can fenretinide protect women against ovarian cancer? J. Natl. Cancer Inst., 87: 146-147, 1995.
9. Delia, D., Aiello, A., Lombardi, L., Pelicci, P. G., Grignani, F., Formelli, F., Menard, S., Costa, A., Veronesi, U., and Pierotti, M. A. N-(4-Hydroxyphenyl)retinamide induces apoptosis of malignant hematopoietic cell lines including those unresponsive to retinoic acid. Cancer Res., 53: 6036-6041, 1993.
10. Mariotti, A., Marcora, E., Bunone, G., Costa, A. Veronesi, U., Pierotti, M. A., and Valle, G. D. N-(4-Hydroxyphenyl)retinamide: a potent inducer of apoptosis in human neuroblastoma cells. J. Natl. Cancer Inst., 86: 1245-1247, 1994.
11. Oridate, N., Lotan, D., Mitchell, M. F., Hong, W. K., and Lotan, R. Induction of apoptosis by retinoids in human cervical carcinoma cell lines. Int. J. Oncol., 7: 433-441, 1995.
12. Sheikh, M. S., Shao, Z-M., Li, X-S., Ordonez, J. V., Conley, B. A., Wu, S., Dawson, M. I., Han, Q-X., Chao, W-R., Quick, T., Niles, R. R., and Fontana, J. A. N-(4-Hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma. Carcinogenesis (Lond.), 16: 2477-2486, 1995.
13. Supino, R., Crosti, M., Clerici, M., Warlters, A., Cleris, L., Zunino, F., and Formelli, F. Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression. Int. J. Cancer, 65: 491-497, 1996.
14. Oridate, N., Lotan, D., Xu, X. C., Hong, W. K., and Lotan, R. Differential induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in human head and neck squamous carcinoma cell lines. Clin. Cancer Res., 2: 855-863, 1996.
15. Kalemkerian, G. P., Slusher, R., Ramalingam, S., Gadgeel, S., and Mabry, M. Growth inhibition and induction of apoptosis by fenretinide in small-cell lung cancer cell lines. J. Natl. Cancer Inst., 87: 1674-1680, 1995.
16. Chambon, P. A decade of molecular biology of retinoic acid receptors. FASEB J., 10: 940-954, 1996.
17. Sani, B. P. Binding affinities of retinoids to their binding proteins/receptors and their biological activities. In: M. A. Livrea and L. Packer (eds.), Retinoids: Progress in Research and Clinical Applications. pp. 337-347. New York: Marcel Dekker, Inc., 1993.
18. Kazmi, S. M., Plante, R. K., Visconti, V., and Lau, C. Y. Comparison of N-(4-hydroxyphenyl)retinamide and all-trans-retinoic acid in the regulation of tretionoid receptor-mediated gene expression in human breast cancer cell lines. Cancer Res., 56: 1056-1062, 1996.
19. Fanjul, A. N., Delia, D., Pierotti, M. A., Rideout, D., Qiu, J., and Pfahl, M. 4-Hydroxylphenyl retinamide is a highly selective activator of retinoid receptors. J. Biol. Chem., 271: 22441-22446, 1996.
20. Oridate, N., Suzuki, S., Higuchi, M., Mitchell, M. F., Hong, W. K., and Lotan, R. Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. J. Natl. Cancer Inst., 89: 1191-1198, 1997.
21. Delia, D., Aiello, A., Formelli, F., Fontanella, E., Costa, A., Miyashita, T., Reed, J. C., and Pierotti, M. A. Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl)retinamide and effect of deregulated bcl-2. Blood, 85: 3659-3675, 1995.
22. Delia, D., Aiello, A., Meroni, L., Nicolini, M., Reed, J. C., and Pierotti, M. A. Role of antioxidants and intracellular free radicals in retinamide-induced cell death. Carcinogenesis (Lond.), 18: 943-948, 1997.
23. Simizu, S., Imoto, M., Masuda, N., Takada, M., and Umezawa, K. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res., 56: 4978-4982, 1996.
24. Hiraku, Y., and Kawanishi, S. Oxidative DNA damage and apoptosis induced by benzene metabolites. Cancer Res., 56: 5172-5178, 1996.
25. Hockenbery, D. M., Oltvai, Z. N., and Yin, X-M., Milliman, C., and Korsmeyer, S. J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75: 241-251, 1993.
26. Sugimoto, C., Matsukawa, S., Fujieda, S., Noda, I., Tanaka, N., Tsuzuki, H., and Saito, H. Involvement of intracellular glutathione in induction of apoptosis by cisplatin in a human pharyngeal carcinoma cell line. Anticancer Res., 16: 675-680, 1996.
27. Slater, A. F., Nobel, I., and Orrenius, S. The role of intracellular oxidants in apoptosis. Biochim. Biophys. Acta, 1271: 59-62, 1995.
28. Slater, A. F., Stefan, C., Nobel, I., van den Dobbelsteen, D. J., and Orrenius, S. Signaling mechanisms and oxidative stress in apoptosis. Toxicol. Lett., 82-83: 149-153, 1995.
29. Powis, G., Gasdaka, J. R., and Baker, A. Redox signaling and the control of cell growth and death. Adv. Pharmacol., 38: 329-359, 1997.
30. Sun, S-Y., Yue, P., Shroot, B., Mitchel, S., Dawson, M. I., Lamph, W. W., Heyman, R. A., Teng, M., Chandraratna, R. A. S., Shudo, K., Hong, W. K., and Lotan, R. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res., 57: 4931-4939, 1997.
31. Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. B., Valentine, J. S., Ord, T., and Bredesent, D. E. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science (Washington DC), 262: 1274-1277, 1993.
32. Kurit, T., and Namiki, H. Apoptotic cell death induced by serum and its prevention by thiols. J. Cell. Physiol., 161: 63-70, 1994.
33. Peled-Kamer, M., Lotem, J., Okon, E., Sachs, L., and Groner, Y. Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome. EMBO J., 14: 4985-4993, 1995.
34. Dmitrovsky, E. N-(4-Hydroxyphenyl)retinamide activation of a distinct pathway signaling apoptosis. J. Natl. Cancer Inst., 89: 1179-1181, 1997.
35. Fuchs, D., Baier-Bitterlich, G., Wede, I., and Wachter, H. Reactive oxygen and apoptosis. In: J. G. Scandalios (eds), Oxidative Stress and the Molecular Biology of Antioxidant Defenses, pp. 139-167. Plainview, NY: Cold Spring Harbor Laboratory, 1997.
36. Orrenius, S., McConkey, D. J., and Nicotera, P. Mechanisms of oxidant-induced cell damage. In: P. A. Cerutti, I. Fridovich, and J. M. McCord (eds.), Oxy-Radicals in Molecular Biology and Pathology, pp. 327-339. New York: Alan R. Liss, Inc., 1988.