Interferon alfa-2a is ineffective for patients with choroidal neovascularization secondary to age-related macular degeneration: Results of a prospective randomized placebo-controlled clinical trial

Archives of Ophthalmology

Volumn 115, Issue 7, 1997, Pages 865-872

  Guyer, David R ^a   Adamis, Anthony P ^b   Yannuzzi, Lawrence A ^a   Gragoudas, Evangelos S ^b   Coscas, Gabriel J ^c   Brancato, Rosario ^d   Bird, Alan C ^e   Soubrane, Gisele ^c   Miller, Joan W ^b   Bressler, Neu M ^f   Slakter, Jason S ^a   Buyse, Marc ^h   O'Shaughnessy, Denis ^g   DeRosa, Janet T ^a  

^a EAR AND THROAT HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e MOORFIELDS EYE HOSPITAL   (United Kingdom)

^f JOHNS HOPKINS UNIVERSITY   (United States)

^g HOFFMANN LA ROCHE INC   (United States)

^h INTERNATIONAL DRUG DEVELOPMENT INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ALPHA2A INTERFERON;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FOLLOW UP; HUMAN; IMMUNOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA MACULA DEGENERATION; SUBRETINAL NEOVASCULARIZATION; TREATMENT FAILURE;

EID: 8544270082     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.1997.01100160035005     Document Type: Article

References (21)

1. Macular Photocoagulation Study Group. Argon laser photocoagulation for senile macular degeneration: results of a randomized clinical trial. Arch Ophthalmol. 1992;100:912-918.
2. Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration: results of a randomized clinical trial. Arch Ophthalmol. 1991;109:1220-1231.
3. Freund KB, Yannuzzi LA, Sorenson JA. Age-related macular degeneration of choroidal neovascularization. Am J Ophthalmol. 1993;115:786-791.
4. Macular Photocoagulation Study Group. Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Arch Ophthalmol. 1990;108:825-831.
5. Sorenson JA, Yannuzzi LA, Shakin JL. Recurrent subretinal neovascularization. Ophthalmology. 1985;92:1059-1074.
6. Brouty-Boye O, Zetter B. Inhibition of cell motility by Interferon. Science. 1980; 108:516-518.
7. Friesel R, Komariya A, Maciag T. Inhibition of endothelial cell proliferation by gamma Interferon. J Cell Biol. 1987;104:689-696.
8. Sidky Y, Borden E. Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced responses. Cancer Res. 1987;47:5155-5161.
9. Miller JW, Stinson WG, Folkman J. Regression of iris neovascularization with systemic alfa-interferon. Ophthalmology. 1993;100:9-14.
10. White CW, Sonheimer HM, Crouch EC, Wilson H, Fan LL. Treatment of pulmonary hemangiomatosis with recombinant Interferon alfa-2a. N Engl J Med. 1989; 320:1197-1200.
11. Ezekowitz RA, Mulliken JB, Folkman J. Interferon alfa 2a therapy for life-threatening hemangiomas of infancy. N Engl J Med. 1992;326:1456-1463.
12. Krown SE, Real FX, Vadhan-Raj S, et al. Kaposi's sarcoma and the acquired immune deficiency syndrome: treatment with recombinant Interferon alfa and analysis of prognostic factors. Cancer. 1986;57(suppl 8):1662-1665.
13. Guyer DR, Adamis AP, Gragoudas ES, Folkman J, Slakter JS, Yannuzzi LA. Systemic antiangiogenic therapy for choroidal neovascularization: what is the role of Interferon alfa? Arch Ophthalmol. 1992;110:1383-1384.
14. Engler CB, Sander B, Krofoed P, Larsen M, Vinding R, Lund-Anderson H. Interferon alfa-2a treatment of patients with subfoveal neovascular macular degeneration: a pilot investigation. Acta Scand Ophthalmol. 1993;71:27-31.
15. Fung WE. Interferon alfa-2a for treatment of age-related macular degeneration. Am J Ophthalmol. 1991;112:349-350.
16. Thomas MA, Ibanez HE. Interferon alfa-2a in the treatment of subfoveal choroidal neovascularization. Am J Ophthalmol. 1993;115:563-568.
17. Poliner LS, Tomambe PE, Michelson PE, Heitzmann JG. Interferon alfa-2a for subfoveal neovascularization in age-related macular degeneration. Ophthalmology. 1993;100:1417-1424.
18. Kirkpatrick JP, Dick AD, Forrester JV. Clinical experience with Interferon alfa-2a for exudative age-related macular degeneration. Br J Ophthalmol. 1993;77:766-770.
19. Gillies MC, Sarks JP, Beaumont PE, et al. Treatment of choroidal neovascularization in age-related macular degeneration with Interferon alfa-2a and alfa-2b. Br J Ophthalmol. 1993;77:759-765.
20. Lewis ML, Davis J, Chuang E. Interferon alfa-2a in the treatment of exudative age-related macular degeneration. Graetes Arch Clin Exp Ophthalmol. 1993;231:615-618.
21. Guyer DR, Tiedeman J, Yannuzzi LA, et al. Interferon associated retinopathy. Arch Ophthalmol. 1993;1 11:350-356.