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The use of the bisbenzamide of the 1,1′-binaphthyl diarnine as organocatalyst led to the formation of the chiral amine in only 20% yield and with no stereoselectivity, as clear demonstration of the fundamental role of the picolinamide moiety to guarantee high chemical and stereochemical efficiency of the catalyst
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The use of the bisbenzamide of the 1,1′-binaphthyl diarnine as organocatalyst led to the formation of the chiral amine in only 20% yield and with no stereoselectivity, as clear demonstration of the fundamental role of the picolinamide moiety to guarantee high chemical and stereochemical efficiency of the catalyst.
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35
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67650688705
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The introduction of a substituent in the 3 or 6 position of the pyridine ring decreased the stereochemical efficiency of the catalyst, while substitution in the 4 position seems not to have any remarkable effect
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The introduction of a substituent in the 3 or 6 position of the pyridine ring decreased the stereochemical efficiency of the catalyst, while substitution in the 4 position seems not to have any remarkable effect.
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0141630303
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