Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis

Journal of Zhejiang University: Science B

Volumn 10, Issue 7, 2009, Pages 493-498

  Zhang, Xi Ping ^a   Chen, Han Qing ^b   Liu, Fang ^c   Zhang, Jie ^b  

^a HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^c HANGZHOU RED CROSS HOSPITAL   (China)

Author keywords

Dysregulation; Immune; Severe acute pancreatitis (SAP); Treatment

Indexed keywords

CYCLOPHOSPHAMIDE; DEXAMETHASONE; ELASTASE; ENDOTHELIN; FLUOROURACIL; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; METHOTREXATE; PHOSPHOLIPASE; PYRUVIC ACID; THROMBOCYTE ACTIVATING FACTOR; THYMOSIN ALPHA1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; CELLULAR IMMUNITY; DISEASE SEVERITY; ENZYME ACTIVATION; HUMAN; HUMORAL IMMUNITY; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOTHERAPY; LYMPHOCYTE COUNT; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; SURVIVAL RATE; T LYMPHOCYTE; TH1 CELL; TH2 CELL; UPREGULATION;

ACUTE DISEASE; ANIMALS; BIOMEDICAL RESEARCH; CYTOKINES; HUMANS; IMMUNITY, INNATE; MODELS, IMMUNOLOGICAL; PANCREATITIS;

EID: 67650632725     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B0820265     Document Type: Review

References (35)

1. Al Mofleh, I.A., 2008. Severe acute pancreatitis: Pathogenetic aspects and prognostic factors. World J. Gastroenterol., 14 (5):675-684. [doi:10.3748/wjg.14.675]
2. Armutcu, F., Coskun, O., Gürel, A., Kanter, M., Can, M., Ucar, F., Unalacak, M., 2005. Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats. Clin. Biochem., 38 (6):540-547. [doi:10.1016/j.clinbiochem.2005.01.013]
3. Ayala, A., Chung, C.S., Song, G.Y., Chaudry, I.H., 2001. IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis. Cytokine, 14 (1):37-48. [doi:10.1006/ cyto.2001.0848]
4. Beger, H.G., Rau, B.M., 2007. Severe acute pancreatitis: Clinical course and management. World J. Gastroenterol., 13 (38):5043-5051.
5. Chen, C., Xia, S.H., Chen, H., Li, X.H., 2008. Therapy for acute pancreatitis with platelet-activating factor receptor antagonists. World J. Gastroenterol., 14 (30):4735-4738. [doi:10.3748/wjg.14.4735]
6. Chen, X.L., Huang, X.L., Wu, H., 2002. Modulation of disorder of inflammatory-associated cytokines with immunosuppressive agents in acute pancreatitis. Chinese Journal of Bases and Clinics in General Surgery, 9 (6):384-387 (in Chinese).
7. DiMagno, M.J., DiMagno, E.P., 2007. New advances in acute pancreatitis. Curr. Opin. Gastroenterol., 23 (5):494-501.
8. Fink, M.P., 2008. Ethyl pyruvate. Curr. Opin. Anaesthesiol., 21 (2):160-167. [doi:10.1097/ACO.0b013e3282f63c2e]
9. Frossard, J.L., Steer, M.L., Pastor, C.M., 2008. Acute pancreatitis. Lancet, 371 (9607):143-152. [doi:10.1016/S0140-6736(08)60107-5]
10. Fushimi, T., Okayama, H., Seki, T., Shimura, S., Shirato, K., 1997. Dexamethasone suppressed gene expression and production of interleukin-10 by human peripheral blood mononuclear cells and monocytes. Int. Arch. Allergy Immunol., 112 (1):13-18.
11. Gloor, B., Stahel, P.F., Müller, C.A., Schmidt, O.I., Büchler, M.W., Uhl, W., 2003. Predictive value of complement activation fragments C3a and sC5b-9 for development of severe disease in patients with acute pancreatitis. Scand. J. Gastroenterol., 38 (10):1078-1082. [doi:10.1080/ 00365520310005965]
12. Han, X.C., Zhang, Y.C., Wang, Y., Jia, M.K., 2003. Clinical evaluation of serum interleukin 10 in patients with acute pancreatitis. Hepatobiliary Pancreat. Dis. Int., 2 (1): 135-138.
13. Hartwig, W., Klafs, M., Kirschfink, M., Hackert, T., Schneider, L., Gebhard, M.M., Büchler, M.W., Werner, J., 2006. Interaction of complement and leukocytes in severe acute pancreatitis: Potential for therapeutic intervention. Am. J. Physiol. Gastrointest. Liver Physiol., 291 (5):G844-G850. [doi:10.1152/ajpgi.00016.2006]
14. Hayashi, T., Ishida, Y., Kimura, A., Iwakura, Y., Mukaida, N., Kondo, T., 2007. IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation. J. Immunol., 178 (11):7385-7394.
15. Iwagaki, H., Hizuta, A., Uomoto, M., Takeuchi, Y., Kohoka, H., Okamoto, T., Tanaka, N., 1997. Clinical value of cytokine antagonists in infectious complications. Res. Commun. Mol. Pathol. Pharmacol., 96 (1):25-34.
16. Krivoruchko, I.A., Boîko, V.V., Pesotskiî, O.N., Shevchenko, R.S., Klimova, E.M., Drozdova, L.A., 2003. The role of immune disorders information of local and systemic complications of severe acute pancreatitis. Klin. Khir., (2):20-24 (in Russian).
17. Kylänpää-Bäck, M.L., Takala, A., Kemppainen, E., Puolakkainen, P., Kautiainen, H., Jansson, S.E., Haapiainen, R., Repo, H., 2001. Cellular markers of systemic inflammation and immune suppression in patients with organ failure due to severe acute pancreatitis. Scand. J. Gastroenterol., 36 (10):1100-1107. [doi:10.1080/ 003655201750422738]
18. Kylanpaa, M.L., Mentula, P., Kemppainen, E., Puolakkainen, P., Aittomaki, S., Silvennoinen, O., Haapiainen, R., Repo, H., 2005. Monocyte anergy is present in patients with severe acute pancreatitis and is significantly alleviated by granulocyte-macrophage colony-stimulating factor and interferon-gamma in vitro. Pancreas, 31 (1):23-27. [doi:10.1097/01.mpa.0000164449.23524.94]
19. Ma, M., Geng, Z.Q., He, X.Y., 2002. Improving the prognosis of severe acute pancreatitis by using dexamethasone inhibiting inflammatory mediators. Journal of the Fourth Military Medical University, 23 (10):932-934 (in Chinese).
20. Ma, T., Kang, C., Shao, H., Qi, Q., Hu, W., 2006. Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis. Eur. Surg. Res., 38 (5):445-450. [doi:10.1159/000095087]
21. Malleo, G., Mazzon, E., Siriwardena, A.K., Cuzzocrea, S., 2007. Role of tumor necrosis factor-alpha in acute pancreatitis: From biological basis to clinical evidence. Shock, 28 (2):130-140. [doi:10.1097/ shk.0b013e3180487ba1]
22. Matsumura, N., Takeyama, Y., Ueda, T., Yasuda, T., Shinzeki, M., Sawa, H., Nakajima, T., Kuroda, Y., 2007. Decreased expression of toll-like receptor 2 and 4 on macrophages in experimental severe acute pancreatitis. Kobe. J. Med. Sci., 53 (5):219-227.
23. Ohmoto, K., Yamamoto, S., 2005. Serum interleukin-6 and interleukin-10 in patients with acute pancreatitis: Clinical implications. Hepatogastroenterology, 52 (64):990-994.
24. Paulino, E.C., de Souza, L.J., Molan, N.A., Machado, M.C., Jancar, S., 2007. Neutrophils from acute pancreatitis patients cause more severe in vitro endothelial damage compared with neutrophils from healthy donors and are differently regulated by endothelins. Pancreas, 35 (1): 37-41. [doi:10.1097/MPA.0b013e31805c177b]
25. Pietruczuk, M., Dabrowska, M.I., Wereszczynska-Siemiatkowska, U., Dabrowski, A., 2006. Alteration of peripheral blood lymphocyte subsets in acute pancreatitis. World J. Gastroenterol., 12 (33):5344-5351.
26. Pooran, N., Indaram, A., Singh, P., Bank, S., 2003. Cytokines (IL-6, IL-8, TNF): Early and reliable predictors of severe acute pancreatitis. J. Clin. Gastroenterol., 37 (3):263-266. [doi:10.1097/ 00004836-200309000-00013]
27. Rau, B.M., Krüger, C.M., Hasel, C., Oliveira, V., Rubie, C., Beger, H.G., Schilling, M.K., 2006. Effects of immunosuppressive and immunostimulative treatment on pancreatic injury and mortality in severe acute experimental pancreatitis. Pancreas, 33 (2):174-183. [doi:10.1097/ 01.mpa.0000226895.16817.a1]
28. Romagnani, S., 2000. T-cell subsets (Th1 versus Th2). Ann. Allergy Asthma Immunol., 85 (1):9-18.
29. Roxvall, L., Bengtson, A., Sennerby, L., Heideman, M., 1991. Activation of the complement cascade by trypsin. Biol. Chem. Hoppe. Seyler., 372 (4):273-278.
30. Schütte, K., Malfertheiner, P., 2008. Markers for predicting severity and progression of acute pancreatitis. Best Pract. Res. Clin. Gastroenterol., 22 (1):75-90. [doi:10.1016/j.bpg.2007.10.013]
31. Sjogren, M.H., 2004. Thymalfasin: An immune system enhancer for the treatment of liver disease. J. Gastroenterol. Hepatol., 19 (s6):S69-S72. [doi:10.1111/j.1440-1746.2004.03635.x]
32. Skipworth, J.R., Pereira, S.P., 2008. Acute pancreatitis. Curr. Opin. Crit. Care, 14 (2):172-178. [doi:10.1097/MCC.0b013e3282f6a3f9]
33. Ueda, T., Takeyama, Y., Yasuda, T., Shinzeki, M., Sawa, H., Nakajima, T., Ajiki, T., Fujino, Y., Suzuki, Y., Kuroda, Y., 2006. Immunosuppression in patients with severe acute pancreatitis. J. Gastroenterol., 41 (8):779-784. [doi:10.1007/s00535-006-1852-8]
34. Yao, W., Zhu, Q., Yuan, Y., Qiao, M., Zhang, Y., Zhai, Z., 2007. Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum level. J. Gastroenterol. Hepatol., 22 (11):1866-1871. [doi:10.1111/ j.1440-1746.2006.04699.x]
35. Yasuda, T., Takeyama, Y., Ueda, T., Takase, K., Nishikawa, J., Kuroda, Y., 2002. Splenic atrophy in experimental severe acute pancreatitis. Pancreas, 24 (4):365-372. [doi:10.1097/00006676-200205000-00007]